HOME >> BIOLOGY >> NEWS
Cancer killing gene found by Dartmouth researchers

Cancer Killing Gene Found by Dartmouth Researchers Hanover, NH - Dartmouth Medical School cancer researchers have identified a gene that triggers the death of leukemia cells, opening a novel target for anti-cancer drugs.

This new genetic switch, reported in the March 19 issue of the Proceedings of the National Academy of Sciences, turns on a program to destroy certain leukemic cells and possibly other tumor cells. It is activated by treatment with retinoic acid, a vitamin A derivative used in cancer therapy and prevention.

Finding a mechanism that sets a cell death program in motion paves the way for developing new cancer-killing drugs, according to Ethan Dmitrovsky, professor and chair of pharmacology and toxicology. He headed the research team that included Sutisak Kitareewan, Ian Pitha-Rowe, Sarah Freemantle and David Sekula.

Retinoids are natural or synthetic compounds derived from vitamin A. The retinoid all-trans retinoic acid (RA) causes remissions in acute promyelocytic leukemia (APL), a rare, but lethal leukemia. This leukemia is marked by an unusual genetic defect that rearranges the receptor for RA. A hallmark of this retinoid response is the degradation of the abnormal receptor that causes this disease.

Studying the RA pathway, the DMS team found a target gene that appears to mimic the drug action, degrade the abnormal receptor and induce cell death. When introduced into leukemic cells, this gene, called UBE1L, reproduced key aspects of retinoic acid response and caused the death of leukemic cells.

"This is exciting because we have identified a potential pharmacological target that signals a death program in leukemia and perhaps other cancer cells as well," says first author Kitareewan.


'"/>

Contact: Stephen Snyder
dms.communications@dartmouth.edu
603-650-1492
Dartmouth Medical School
18-Mar-2002


Page: 1

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: