HOME >> BIOLOGY >> NEWS
Cancer squeezes through the gaps

Cancer cells move around the body (become metastatic) by chopping up the dense matrix that surrounds them. But drugs that prevent the chopping have been disapointing in animal and human anti-cancer trials. Now researchers provide an explanation for this failure: the drug-treated cells revert to a primordial, ameboid form of cell movement that allows them to squeeze through gaps in the matrix.

Peter Friedl (University of Wuerzburg, Germany) and colleagues report in the January 20 issue of The Journal of Cell Biology that cancer cells moving through a protein matrix leave a path of destruction behind them. But when that destruction is prevented, the cells still move at a rapid rate by reverting to a more rounded, ameboid shape that is distorted as the cells squeeze through any available gaps.

This type of migration could serve as a "salvage" pathway, allowing tumor cells to take a step backward in evolutionary time to continue migrating in the presence of inhibitors. Drugs that attack both migration pathways should have a better chance of being effective against the spread of cancer.


'"/>

Contact: Lynette Henry
212-327-7938
Journal of Experimental Medicine
20-Jan-2003


Page: 1

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer squeezes through the gaps

(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
(Date:4/2/2015)... Germany , April 2, 2015 ... fingerprint tests DERMALOG by far outperforms the strongest ... always maintaining high accuracy, the system is capable ... Hence, the speed proves up to be ten ... faster than its runner-up performance.      ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
(Date:5/27/2015)... , May 27, 2015  Tikcro Technologies Ltd. ... ended March 31, 2015. Aviv ... we continued pre-clinical work to generate functional specific antibodies, ... early stage, we are encouraged by the development progress. ... as new antibodies which modulate immune checkpoints gain clinical ...
(Date:5/27/2015)... Calif. , May 27, 2015  CytomX, ... treatment of cancer, today announced the appointments of ... and Cynthia Ladd as senior vice ... Goeltz was chief financial officer of Onyx Pharmaceuticals, ... an independent consultant and legal counsel to several ...
(Date:5/27/2015)... THOUSAND OAKS, Calif. , May 27, 2015 /PRNewswire/ ... company, has been awarded a U.S. patent for a ... gene in areas such as research, product development and ... useful in regulating key biosynthetic processes that are the ... to offer other seed companies a commercial license to ...
(Date:5/27/2015)... Madison, NJ (PRWEB) May 27, 2015 ... for evaluating the impact of regulation on medical innovation, ... Centered Innovation (iPCI) of Fairleigh Dickinson University’s ( ... inaugural MI3 Alert pertains to new FDA ... Senate proposal for accelerating the approval of certain medical ...
Breaking Biology Technology:Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3CytomX Expands Executive Leadership Team 2CytomX Expands Executive Leadership Team 3Ceres Awarded Patent for Innovation in Soybean 2Ceres Awarded Patent for Innovation in Soybean 3Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2
Cached News: