HOME >> BIOLOGY >> NEWS
Cancer squeezes through the gaps

Cancer cells move around the body (become metastatic) by chopping up the dense matrix that surrounds them. But drugs that prevent the chopping have been disapointing in animal and human anti-cancer trials. Now researchers provide an explanation for this failure: the drug-treated cells revert to a primordial, ameboid form of cell movement that allows them to squeeze through gaps in the matrix.

Peter Friedl (University of Wuerzburg, Germany) and colleagues report in the January 20 issue of The Journal of Cell Biology that cancer cells moving through a protein matrix leave a path of destruction behind them. But when that destruction is prevented, the cells still move at a rapid rate by reverting to a more rounded, ameboid shape that is distorted as the cells squeeze through any available gaps.

This type of migration could serve as a "salvage" pathway, allowing tumor cells to take a step backward in evolutionary time to continue migrating in the presence of inhibitors. Drugs that attack both migration pathways should have a better chance of being effective against the spread of cancer.


'"/>

Contact: Lynette Henry
212-327-7938
Journal of Experimental Medicine
20-Jan-2003


Page: 1

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Cancer gene MYC emerging as key research target
5. Cancer patient, heal thyself
6. USC researcher named General Motors Cancer Research Scholar
7. Fox Chase Cancer Centers Alfred Knudson Jr. named 2004 Kyoto Prize winner
8. Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
9. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. National Cancer Gene Therapy Foundation gives $4.0 million in research grants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... The ... the focus of researchers, engineers, product developers, and industry suppliers gathered last week ... by SPIE, the international society for optics and photonics , the event ...
(Date:4/20/2017)... , ... April 20, 2017 , ... ... , this new webinar will explore challenging patient cases when screening for direct ... hospital, there may be a need for bridging parental anticoagulation especially for those ...
(Date:4/20/2017)... ... April 20, 2017 , ... Husson ... clinical research community’s growing body of knowledge during its Eighth Annual Research ... and the adjacent Darling Atrium. During the event, undergraduates, graduate students, and faculty ...
(Date:4/20/2017)... ... April 20, 2017 , ... Parallel6™ , the leader ... announced today that they were named one of the 2017 Top 10 eClinical ... developments in the pharmaceutical industry. , “We take pride in honoring Parallel6 as one ...
Breaking Biology Technology:
Cached News: