HOME >> BIOLOGY >> NEWS
Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified

In a joint effort, the groups of Heinrich Betz from the Max Planck Institute for Brain Research (Frankfurt, Germany) and George Augustine from the Duke University (Durham, NC) have tested the hypothesis that NSF, a ubiquitous protein required for a variety of general membrane fusion and secretion events in eukaryotic cells, is also involved in neurotransmitter release at synapses. Their results, appearing in the February 20 issue of SCIENCE, provide the first hints at molecular events that may control the time course of neurotransmitter release.

Nerve cells release neurotransmitter by allowing transmitter containing organelles, so called synaptic vesicles, to fuse with the neuronal plasma membrane, thus secreting their content. This process has recently been found to share many similarities with general vesicle trafficking events, e.g. protein transport to the cell surface, as employed by cells from yeast to mammals. The major differences are speed - synaptic vesicles can perform secretion within 200 microseconds after arrival of a stimulus - and tight control by calcium levels, which must rise thousandfold to trigger vesicle fusion. Using a combination of molecular biological and physiological techniques, the groups of Betz and Augustine now have found evidence that the speed of transmitter release itself may be controlled, somewhat ironically, by the evolutionarily highly conserved general fusion protein NSF (for N-methylmaleimide sensitive fusion protein). The groups have synthesized NSF-fragments and screened these peptides for their potency to prevent the major activator of NSF, the soluble NSF-attachment protein SNAP, from interacting with NSF in vitro. To elucidate the consequences of perturbed NSF-function for an intact synapse, inhibitory peptides were then injected into the nerve termin
'"/>

Contact: George Augustine
georgea@neuro.duke.edu
919-681-6165
Max-Planck-Gesellschaft
20-Feb-1998


Page: 1 2

Related biology news :

1. AAAS US Presidential Candidates Forum
2. US Presidential Candidates Forum
3. Tigecycline - Candidate antibiotic produces 74 percent cure rate in cSSSI patients
4. Candidate genes found which may play a role in cancer progressing from non-invasive to invasive
5. UCSD And NIH Researchers Isolate Candidates For Genetic Basis Of Human Taste
6. New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Gurin)
7. Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
8. Researchers, Regulators, Industry, Consumer Advocates Gather to Discuss Critical Issues Facing the Pharmaceutical Industry
9. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro
10. Neurons Control Brain Immunity: Neurotrophins As Regulators Of Antigen-Presentation In Microglial Cells
11. Regulator Of Fat Thermostat Found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/10/2018)... (PRWEB) , ... December 10, 2018 , ... ... a strategic alliance to advance their shared goal of accelerating the development of ... unique scale-up bioprocess systems to TRT’s core technology around human umbilical cord perivascular ...
(Date:12/5/2018)... ... December 05, 2018 , ... Dr. Nicolas ... symposium 2018, London, England. The 2018 PDT symposium was organized by the RSM ... its benefits in clinical practice across a range of applications in oncology and ...
(Date:12/5/2018)... ... December 04, 2018 , ... ... companies, announces the placement of Michael Mercer at Karius, Inc. as Chief Commercial ... Mercer will be based at Karius' headquarters in Redwood City, California and report ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... November 13, 2018 , ... Sharon Kleyne, founder and new ... Pass, Oregon believes in the power of talk radio education Power of Water® ... the Power of Water® on talk radio every week with the “Sharon Kleyne ...
(Date:11/9/2018)... Fla. (PRWEB) , ... November 08, 2018 , ... ... in the United States, adopted a machine-learning powered approach to increasing recovery rates ... centered around an Artificially Intelligent Collections (AIC) product developed by NLP Logix, a ...
(Date:11/7/2018)... ... November 07, 2018 , ... Diversified Technologies, Inc. ... at AzCATI, the Arizona Center for Algae Technology and Innovation at ASU. Funded by ... and trials for those involved with algal and predator control applications. , Algae ponds ...
(Date:11/5/2018)... ... November 05, 2018 , ... ... backed by Siemens Healthineers and several healthcare VC firms announces at Distributed Health ... making a history by purchasing tokens and obtaining its first radiology interpretations, one ...
Breaking Biology Technology:
Cached News: