HOME >> BIOLOGY >> NEWS
Candidate genes found which may play a role in cancer progressing from non-invasive to invasive

Scientists in America have made the first steps in identifying a group of genes which may be involved in the progression of breast cancer from non-invasive to invasive, the 3rd European Breast Cancer Conference in Barcelona heard today (Thursday 21 March).

Professor Craig Allred, Director of Breast Pathology at the Breast Center, Baylor College of Medicine, Houston, USA, used a technique called microarray to discover which genes might be involved in causing ductal carcinoma in situ (DCIS) to progress to invasive breast cancer (IBC). Microarray studies involve using a microchip bearing thousands of known single-stranded gene fragments on its surface and incubating it with RNA from tissue samples. By seeing which gene fragments the RNA is attracted to it is possible to tell which genes are active in the tissue samples.

Prof Allred said: DCIS is very common and gives rise to most IBCs. We already know that DCIS contains many genetic defects that are responsible for its development in the first place, but we believe that there are many additional genetic defects that must occur in DCIS to cause it to progress to IBC. Identifying the important genes will be useful because finding defects in them could help doctors to predict the outcome for the patients and, more importantly, could give us targets at which we could aim treatments to prevent or suppress invasion.

Analyses of the results from the microarray studies showed that there were at least 100 individual genes which had significantly different levels of activity in DCIS and IBC, and many of these genes are known already to involve processes and pathways which could make them reasonable candidates as invasion-related genes.

Prof Allred said: I dont know whether any of the genes are truly invasion-related, but many of them are involved in biological pathways that are likely to be important in invasion. For example, several integrin genes, which are involved in making cells stick to
'"/>

Contact: Emma Mason
wordmason@aol.com
44-7711-296-986
Federation of European Cancer Societies
21-Mar-2002


Page: 1 2

Related biology news :

1. AAAS US Presidential Candidates Forum
2. US Presidential Candidates Forum
3. Tigecycline - Candidate antibiotic produces 74 percent cure rate in cSSSI patients
4. UCSD And NIH Researchers Isolate Candidates For Genetic Basis Of Human Taste
5. New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Gurin)
6. Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified
7. Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
8. Belgian researchers explore revolutionary approach to angiogenesis
9. Tracing genes, biologists show lizard migration is traced to Florida
10. Certain genes boost fish oils protection against breast cancer
11. Fossil genes reveal how life sheds form and function

Post Your Comments:
(Date:7/30/2014)... ranges and a changing climate threaten some of ... and so conservationists establish seed collections to save ... hopes of preserving some genetic diversity., For decades, ... models that offer a one-size-fits-all approach for how ... 50 seed samples regardless of species, pollination mode, ...
(Date:7/30/2014)... CHAMPAIGN, Ill. Scientists are searching through a massive ... more than 50 years ago, and the effort is ... world they inhabited. , When the collection is fully ... will be the largest unbiased Dominican amber collection in ... most striking discovery thus far is that of a ...
(Date:7/30/2014)... subject of major interest in neuroscience. A large ... distinct stages of Wallerian degeneration: transcription factor activation, ... gene expression responses in the distal segment of ... known, differences in gene expression between the proximal ... and co-workers from Nantong University, China used microarrays ...
Breaking Biology News(10 mins):Saving seeds the right way can save the world's plants 2Decades-old amber collection offers new views of a lost world 2
(Date:7/30/2014)... NCERC at Southern Illinois University Edwardsville ... on corn stover pretreatment methods at a U.S. ... D.C. , “Arun’s selection for presentation at ... to the success of our postdoctoral fellowship program,” ... foresight and vision of SIUE and the Illinois ...
(Date:7/30/2014)... San Diego, CA (PRWEB) July 30, 2014 ... Pipette.com announced their weighing boat special – ... Get 1 free. This promotion will benefit lab technicians ... their work. Weighing boats are ideal for multiple applications ... Pipette.com offers a variety of choices including diamond-shaped, hexagonal, ...
(Date:7/29/2014)... MA (PRWEB) July 30, 2014 ... (UC) and collaboration company, is proud to announce ... account management positions in their Boston, Charleston and ... response to the increased demand for hosted solutions, ... operational efficiency and reduce cost. , SoundConnect was ...
(Date:7/29/2014)... WA (PRWEB) July 29, 2014 The ... of the brain that are driving a revolution in ... a new peer-reviewed journal published by SPIE, the ... first issue coincides with the launch of the BRAIN ... features articles that lay out a vision for and ...
Breaking Biology Technology:NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2SoundConnect Organization and Culture is Evolving 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4
Cached News: