HOME >> BIOLOGY >> NEWS
Candidate genes found which may play a role in cancer progressing from non-invasive to invasive

Scientists in America have made the first steps in identifying a group of genes which may be involved in the progression of breast cancer from non-invasive to invasive, the 3rd European Breast Cancer Conference in Barcelona heard today (Thursday 21 March).

Professor Craig Allred, Director of Breast Pathology at the Breast Center, Baylor College of Medicine, Houston, USA, used a technique called microarray to discover which genes might be involved in causing ductal carcinoma in situ (DCIS) to progress to invasive breast cancer (IBC). Microarray studies involve using a microchip bearing thousands of known single-stranded gene fragments on its surface and incubating it with RNA from tissue samples. By seeing which gene fragments the RNA is attracted to it is possible to tell which genes are active in the tissue samples.

Prof Allred said: DCIS is very common and gives rise to most IBCs. We already know that DCIS contains many genetic defects that are responsible for its development in the first place, but we believe that there are many additional genetic defects that must occur in DCIS to cause it to progress to IBC. Identifying the important genes will be useful because finding defects in them could help doctors to predict the outcome for the patients and, more importantly, could give us targets at which we could aim treatments to prevent or suppress invasion.

Analyses of the results from the microarray studies showed that there were at least 100 individual genes which had significantly different levels of activity in DCIS and IBC, and many of these genes are known already to involve processes and pathways which could make them reasonable candidates as invasion-related genes.

Prof Allred said: I dont know whether any of the genes are truly invasion-related, but many of them are involved in biological pathways that are likely to be important in invasion. For example, several integrin genes, which are involved in making cells stick to
'"/>

Contact: Emma Mason
wordmason@aol.com
44-7711-296-986
Federation of European Cancer Societies
21-Mar-2002


Page: 1 2

Related biology news :

1. AAAS US Presidential Candidates Forum
2. US Presidential Candidates Forum
3. Tigecycline - Candidate antibiotic produces 74 percent cure rate in cSSSI patients
4. UCSD And NIH Researchers Isolate Candidates For Genetic Basis Of Human Taste
5. New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Gurin)
6. Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified
7. Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
8. Belgian researchers explore revolutionary approach to angiogenesis
9. Tracing genes, biologists show lizard migration is traced to Florida
10. Certain genes boost fish oils protection against breast cancer
11. Fossil genes reveal how life sheds form and function

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017  Kingfisher Talent, ... search and leadership development, and Virdis Group, global executive search ... exclusive alliance that enables clients to leverage the expertise and ... "For our clients here in the Boston ... diverse population of leadership talent throughout the US, ...
(Date:8/15/2017)... ... August 15, 2017 , ... Pittcon is pleased to ... and scientific instruments. This year’s symposium, organized by the Pittcon 2018 program chair, ... Bioanalytical Applications.” This dynamic presentation will discuss novel ionization processes, high throughput IMS-MS ...
(Date:8/15/2017)... Linda, Ca (PRWEB) , ... August 15, 2017 ... ... coffee production and is threatened by various biotic and abiotic factors. During this ... complex evolutionary history of coffee, as well as gain a better understanding of ...
(Date:8/14/2017)... ... 14, 2017 , ... The Conference Forum has confirmed the one-day ... on September 6, 2017 at the Marriott Copley Place in Boston, MA. , Returning ... and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, who leads 19 industry speakers in ...
Breaking Biology Technology:
Cached News: