Carbon monoxide has unexpected benefits, but don't try it at home

New York, NY - April 27, 2001 -- A toxic component of industrial emissions, exhaust and cigarette smoke, carbon monoxide starves our cells of oxygen by replacing oxygen molecules in the blood. Exposure to carbon monoxide can have fatal consequences. But surprisingly, according to a new study by Columbia University researchers, carbon monoxide may also have a life-saving effect when blood vessels are blocked, such as during heart attack or stroke. The results "point to potential therapeutic uses for inhaled carbon monoxide," the study's authors say. The paper is published in the May issue of Nature Medicine.

Lead author David J. Pinsky, M.D., associate professor of medicine at the Columbia University College of Physicians & Surgeons, also has signaled a need for caution. "There's more work that needs to be done to identify the conditions under which this is useful and the doses that are safe," he said. "Like many other molecules that are beneficial in the right doses, too much of them can have a lethal effect."

Carbon monoxide (CO) appears to help restore blood flow to organs threatened with a cut off blood supply, according to the authors. It does so by enhancing the body's own clot-dissolving mechanisms and by dilating blood vessels. The researchers demonstrated the results in mice.

At lower than lethal doses, it seems, "CO can paradoxically either imperil or salvage tissue by disparate mechanisms," the authors report.

The body itself produces carbon monoxide when a part of the organism becomes oxygen-starved due to blood vessel blockage, a condition called ischemia. The carbon monoxide is created as part of a natural process in which an enzyme called heme oxygenase type 1 breaks down vital molecules called hemes, when the cells carrying them wear out.

Through as-yet poorly understood mechanisms, heme oxygenase type 1 levels rise during ischemia, stepping up this process and increasing carbon monoxide levels.

Carbon monoxide next

Contact: Carolyn Conway
Columbia University Medical Center

Page: 1 2

Related biology news :

1. A shrinking sink? Carbon fertilization may be flimsy weapon against warming
2. Carbon dioxide fertilization is neither boon nor bust
3. Carbon nanotubes found to fluoresce
4. Carbon sequestration: seeing the forest for its trees
5. Carbon cycling and species composition: seeing the forest for its trees
6. Carbon diem: Grants awarded to research that seizes excess carbon dioxide
7. New Carbon Monoxide Sensor Developed For Occupational Use
8. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent
9. Increasing Carbon Dioxide Threatens Tropical Coral Reefs
10. North America Absorbing Carbon Dioxide At Surprisingly High Rate, Team Reports
11. High Carbon Dioxide Levels May Be Killing Insects

Post Your Comments:

(Date:7/2/2020)... REDWOOD CITY, Calif. (PRWEB) , ... July 01, ... ... stage biotech company, presented its phase 1a findings of Neihulizumab, a biologic for ... annual conference in June 2020. Led by hemato-oncologist Dr. Paul J Martin of ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... biopharmaceutical R&D, today announced that it has entered into a multi-year contract ... (Multiclonics®), to support their translational and clinical research strategy to discover and ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, ... a UK supplier and manufacturer of innovative portable renewable energy equipment, have announced ... fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... 2020 , ... True Terpenes , the leading platform for terpene innovation, ... to research the medical potential of terpenes and the potential entourage effect , ... board is focused on expanding the recently launched line of effects-based terpenes - ...
(Date:8/7/2020)... Texas (PRWEB) , ... August 06, 2020 , ... ... and DNA vaccine industries, announces it has closed on the purchase of greenfield ... Park in Conroe, TX and includes over 21 acres in the initial acquisition, ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, ... that can drive one or two switches in a push-pull configuration; yielding fast ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July ... ... provider of cloud-based software for the life sciences industry, today announced the ... presentation platform designed specifically for Medical Science Liaisons (MSLs) and other field ...
Breaking Biology Technology:
Cached News: