HOME >> BIOLOGY >> NEWS
Cardiovascular system holds a key to circadian clock

Blood pressure varies in all of us throughout the day. This pattern, circadian variability, is exaggerated in patients who have high blood pressure, suggesting that the mechanisms which control this rhythm are disturbed.

Indeed, this altered biorhythm seems to have clinical consequences. Heart attacks and strokes occur most commonly early in the morning when blood pressure is at its highest point in its 24 hour cycle. Scientists at the University of Pennsylvania School of Medicine have discovered another key to the body's circadian clock that may begin to explain these observations and lead to new treatments based on the body's timing mechanism.

Their discovery, which provides the first evidence for how hormones and vitamins can reset the human circadian clock, shows in detail how activation of vitamin A receptors can regulate the rhythm of the clock. This provides an important clue to how the master clock, which lies deep in the brain, can regulate distal organs, such as the liver, kidney and muscle by controlling clocks throughout the body.

The Penn study establishes that blood vessels contain their own peripheral circadian system, similar to clocks in other organs.

Also, significantly, it links hormonal and vitamin control for the first time to the circadian rhythms that control body temperature, sleep and wakefulness , pain sensitivity, and the response to drugs.

"We know that the responseto certain drugs used in the treatment of cancer vary substantially depending on the time of day that they are administered," said Garret FitzGerald, MD, chairman of Penn's Department of Pharmacology and author of the study. "However, this work elucidates a molecular mechanism which permits a refinement of such chronopharmacology. Resetting the clock might have obvious application in the treatment of jet lag, but could also combine with existing knowledge to adjust circadian variability in drug response to the ne
'"/>

Contact: Ellen O'Brien
ellen.obrien@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
28-Jun-2001


Page: 1 2

Related biology news :

1. 1st International Conference on Cell Therapy for Cardiovascular Disease
2. Sex Differences in Cardiovascular Disease
3. Folic Acid Lowers Risk Of Cardiovascular Disease
4. How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
5. Artificial Heart Chamber And Artificial Blood Vessels Aid Cardiovascular Surgeons
6. New Hope On The Horizon For Patients With End-Stage Cardiovascular Disease
7. "Genes, Vitamins, Homocyst(e)ine And Cardiovascular Diseases"
8. Veterans with Gulf War syndrome have damage in specific, primitive portion of nervous system
9. AAAS expert panel calls for voter-system research and reform
10. Information system to help scientists analyze mechanisms of social behavior
11. Probing the surface of white blood cells to enhance immune system medicine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... 04, 2019 , ... Molecular Devices, a global leader in ... new President of Molecular Devices, replacing Greg Milosevich who has been appointed President ... Since joining Molecular Devices in a scientific engineering role, Ms. Murphy has held ...
(Date:6/1/2019)... ... May 31, 2019 , ... The ... Rosati recently invested in BioFactura’s $6M Series B Financing Round. , “With ... institutional investors who bring significant financial and business resources to bear as we ...
(Date:5/31/2019)... ... May 31, 2019 , ... The OilComm Conference ... TX, announced today that Ben Reiter, Senior Writer at Sports Illustrated and Author ... 3rd.     , Reiter predicted the Houston Astros would win the MLB championship in ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... (PRWEB) , ... June 11, 2019 , ... ... of Personalized Stem Cells Inc. (PSC) , has announced that their GMP ... Health, Food and Drug Branch for manufacturing. This is an important milestone ...
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ., a full-service ... today that they will be receiving 3 awards at the 2019 CRO Leadership Awards, ... awards in the categories of overall Quality and Compatibility (Access to desired markets, cultural ...
(Date:5/31/2019)... Redwood City, California (PRWEB) , ... ... ... received allowance of our patent applications from the USPTO providing proprietary interest ... SYSTEM AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP ...
(Date:5/31/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... May 30, ... ... the future of neurotoxins, is pleased to announce the strategic acquisition of Metabiologics, ... for research. The acquisition provides Object exclusive ownership and commercialization rights to a ...
Breaking Biology Technology:
Cached News: