HOME >> BIOLOGY >> NEWS
Carnegie Mellon U. develops microgel to recover enzymes for manufacturing, research assays

Carnegie Mellon University scientists have employed biological molecules to create a microgel that could recover costly enzymes for repeated use in catalyzing commercially important reactions. The microgel could potentially recover any enzyme and theoretically save manufacturers considerable money.

"By enabling efficient enzyme recovery, this microgel system overcomes significant obstacles in using natural enzymes in laboratory and industrial settings," said Bruce Armitage, associate professor of chemistry at Carnegie Mellon, who developed the recoverable enzymatic microgel in collaboration with chemistry professor Gary Patterson, and graduate students Rong Cao and Zhenyu Gu.

Enzymes are routinely used in manufacturing to catalyze important reactions, such as the breakdown of sugars to create lactose-free milk or cheese products for the dairy industry. In many cases, industrial enzymes are embedded in a solid, synthetic matrix to easily separate them from their chemical product after a reaction takes place. But embedded enzymes may eventually leach from a matrix. The chemical cross-linking reaction used to attach the enzymes to the matrix also can inadvertently inactivate the enzymes, rendering them useless. What's more, large chemicals cannot enter a dense matrix to react with embedded enzymes.

The microgel developed by Armitage and Patterson bypasses these limitations. The enzyme is tightly connected to the microgel matrix, but remains fully functional. Molecules can diffuse into the porous microgel and undergo chemical reaction when they encounter an enzyme. The product can then diffuse out of the microgel. Separation of the product from the enzyme takes advantage of the fact that the microgel particles precipitate from solution at a low temperature. After the product has been removed, the microgel particles can be re-suspended by adding fresh water and heating the solution.

"The complete recoverability of the enzymatic activity is encour
'"/>

Contact: Lauren Ward
wardle@andrew.cmu.edu
412-268-7761
Carnegie Mellon University
8-Apr-2004


Page: 1 2 3

Related biology news :

1. Carnegie Mellon researcher tests tools for protecting Anacostia River ecosystem from PCBs
2. Carnegie Mellon scientists reveal ways of studying, resolving PCB contamination in US rivers
3. PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists
4. Carnegie Mellon researchers to demonstrate autonomous robotthat will seek life in Atacama Desert
5. Carnegie Mellon University hosts ACS-PRF summer school on green chemistry
6. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
7. Carnegie Mellon U. imaging study reveals sex-based differences that persist as mice enter adulthood
8. Carnegie Mellon computational biologist Russell Schwartz receives prestigious CAREER award
9. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
10. Carnegie Mellon U. conducts first comprehensive proteomic analysis of developing animal
11. Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/1/2020)... ... April 01, 2020 , ... The ... named Jean-François Duliere as a European Regulatory Advisor. Effective 1 April 2020, Duliere ... and facilities design for biotechnology, oral solid dosage (OSD), and sterile manufacturing. , ...
(Date:3/20/2020)... ... March 20, 2020 , ... ImStem Biotechnology, Inc. ... (ESC) derived mesenchymal stem cells (hES-MSC), through a proprietary method using a trophoblast ... and rare orphan diseases, today announced that the U.S. Food and Drug Administration ...
(Date:3/13/2020)... ... 13, 2020 , ... According to the American Academy of ... possibly be transmitted by aerosol or direct contact with the conjunctiva, the superficial ... precautions to avoid contracting the coronavirus. Touching the eyes while inserting contact lenses ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... ... March 10, 2020 , ... Ortho Clinical Diagnostics, a ... laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of extended antigen in a ... cleared to run on ORTHO VISION® and ORTHO VISION® Max in the United States ...
(Date:3/3/2020)... Ill. (PRWEB) , ... March 03, 2020 , ... ... company serving the pharmaceutical, biotech and medical device industries, was recognized by INC. ... 5,000 puts forward annual lists to note industry leaders greatly impacting their spheres ...
(Date:2/21/2020)... ... February 20, 2020 , ... In a free ... speakers from Synteract including Lisa Dilworth, BS, MS, Vice President Rare, Orphan ... challenges, with feasible strategies and solutions to support patients, sites and sponsors. , When ...
(Date:2/19/2020)... ... February 18, 2020 , ... Shoreline Biome, ... to the strain level, recently unveiled a novel DNA isolation product. , Shoreline ... isolation of high molecular weight (HMW) single-stranded DNA (ssDNA) in excess of 40 ...
Breaking Biology Technology:
Cached News: