HOME >> BIOLOGY >> NEWS
Carnegie Mellon U. imaging study reveals sex-based differences that persist as mice enter adulthood

de with the capability to perform MRM. Koshibu, who did much of the data analysis, recently completed her doctoral work in the department of neurobiology at the University of Pittsburgh while working at the Center for the Neural Basis of Cognition, a joint University of Pittburgh-Carnegie Mellon initiative.

To date, only a limited number of quantitative 3D analyses of adult mouse brain structures have been conducted, due in part to the laborious process required to obtain such data. Using conventional histology, it would take months to section brains, measure various structures and perform a 3D reconstruction, whereas Koshibu obtained statistically relevant results in a matter of weeks with the MRM technique. Moreover, extreme manipulations of the brain needed to carry out histological investigations inevitably distort the tissue, which in turn corrupts the true brain structure, according to Ahrens.

"With MRM, we are able to use intact brains, revealing a much better image of structures in the whole brain compared to widely accepted histological techniques," Ahrens said.

MRM is based on the same principles as MRI, an imaging technology that visualizes the body's internal structures. Both MRI and MRM make use of nuclear magnetic resonance, a phenomena observed in the nuclei of atoms when they are exposed to a magnetic field and pulses of radio waves. MRM uses stronger magnets to capture images at a resolution 10-100 times finer than conventional MRI.

Using MRM, Ahrens and his colleagues imaged the brains of male and female mice, aged 1 month (adolescent) and 3 months (adult). Koshibu used a software program to digitally isolate the whole brain and specific structures from the MRM data. These include the amygdala, hippocampus, striatum, and lateral and third ventricles, structures that have been widely studied in humans because of their implications in cognition and neuropsychiatric disorders. A comparison of the 3D reconstructions
'"/>

Contact: Lauren Ward
wardle@andrew.cmu.edu
412-268-7761
Carnegie Mellon University
28-Jun-2004


Page: 1 2 3

Related biology news :

1. Carnegie Mellon researcher tests tools for protecting Anacostia River ecosystem from PCBs
2. Carnegie Mellon scientists reveal ways of studying, resolving PCB contamination in US rivers
3. PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists
4. Carnegie Mellon researchers to demonstrate autonomous robotthat will seek life in Atacama Desert
5. Carnegie Mellon University hosts ACS-PRF summer school on green chemistry
6. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
7. Carnegie Mellon computational biologist Russell Schwartz receives prestigious CAREER award
8. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
9. Carnegie Mellon U. develops microgel to recover enzymes for manufacturing, research assays
10. Carnegie Mellon U. conducts first comprehensive proteomic analysis of developing animal
11. Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 28, 2020 , ... ... solution for adjunct liquefaction: AMYLEX® 6T. The innovative enzyme enables numerous business ... new segments with locally-sourced raw materials, improve productivity, maximize yield, ensure consistent ...
(Date:5/26/2020)... (PRWEB) , ... May 26, ... ... of enterprise software solutions for biopharmaceutical R&D, today announced that Gritstone Oncology, ... T-cell receptor (TCR)-mimetic bispecific T cell engagers and TCR-based therapeutics, has implemented ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... services specializing in background and medical screening, announces the launch of a ... keeping their workforce safe. The new service is provided by ClearStar’s Medical ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... , ... July 16, 2020 , ... “We are thrilled ... Wave Bioactives. “It’s the only technology of its kind on the market and we ... onions with the protective capacity of traditional cultured ingredients, creating a natural way to ...
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
(Date:7/7/2020)... BOSTON (PRWEB) , ... July 06, 2020 , ... ... Innovative Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of ... Since 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples ...
(Date:6/28/2020)... Calif. (PRWEB) , ... June 25, 2020 , ... The ... the launch of Safe Space™ for businesses of all types to ensure cleanliness, distancing ... LiDAR. , A Safe Space™ enabled business will provide a health performance ...
Breaking Biology Technology:
Cached News: