HOME >> BIOLOGY >> NEWS
Carnegie Mellon develops new process for growing bone

PITTSBURGH-- Carnegie Mellon University's Jeffrey Hollinger and his research team will receive $1.12 million over the next four years from the National Institutes of Health (NIH) to develop a new therapy for regenerating bone.

Bone, often called the structural steel and reinforced concrete of the human body, supports the body the way a steel framework supports a skyscraper, and it protects its vital organs the way a cast-concrete roof protects' its building occupants. "Unfortunately, bone loss is an unavoidable consequence of aging, osteoporosis and many traumatic accidents,'' Hollinger said.

To address the challenges of safe and effective therapy to restore form and function to deficient bone architecture, Hollinger's research team at Carnegie Mellon's Bone Tissue Engineering Center has developed an innovative therapy for growing bone by inserting a non-viral gene into the body to induce cells to grow bone.

"We are injecting the NTF gene into a site where bone is deficient via a synthetic hydro-gel made from a hyaluronic acid-based polymer,'' Hollinger said. "The hydro-gel/NTF is non-immunogenic and is designed to restore form and function to bone deficiencies.''

Some of the first pre-clinical trials will involve growing bone in the jaw, said Hollinger. And according to transportation officials, about 10 percent of vehicle accident injuries involve the jaw and the flat bones in the face. "Restoring periodontal bone loss is a high priority for our team, and Bruce Doll, head of the Department of Periodontology at the University of Pittsburgh is leading this challenge,'' Hollinger said.

Through ever-improving surgical techniques, the replacement of bone has been done via bone grafting either from the patient's own body or from animal (usually cow) bone. But because the human body is inclined to reject most 'non-self' grafts, Hollinger's synthetic approach to growing bone will eliminate immune rejections. His research team includes D
'"/>

Contact: Chriss Swaney
swaney@andrew.cmu.edu
412-268-5776
Carnegie Mellon University
13-Aug-2003


Page: 1 2

Related biology news :

1. Carnegie Mellon researcher tests tools for protecting Anacostia River ecosystem from PCBs
2. Carnegie Mellon scientists reveal ways of studying, resolving PCB contamination in US rivers
3. PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists
4. Carnegie Mellon researchers to demonstrate autonomous robotthat will seek life in Atacama Desert
5. Carnegie Mellon University hosts ACS-PRF summer school on green chemistry
6. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
7. Carnegie Mellon U. imaging study reveals sex-based differences that persist as mice enter adulthood
8. Carnegie Mellon computational biologist Russell Schwartz receives prestigious CAREER award
9. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
10. Carnegie Mellon U. develops microgel to recover enzymes for manufacturing, research assays
11. Carnegie Mellon U. conducts first comprehensive proteomic analysis of developing animal

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/22/2016)... , PROVO and ... Newborn Screening Ontario (NSO), which operates the highest sample ... molecular testing, and Tute Genomics and UNIConnect, leaders in ... respectively, today announced the launch of a project to ... (NGS) testing panel. NSO has been ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... STACS DNA Inc., ... Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field ... DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology:
Cached News: