HOME >> BIOLOGY >> NEWS
Case researchers discover the mouth's defenses against AIDS

Researchers at Case Western Reserve University and the Cleveland Clinic have discovered a way that the mouth may prevent the contraction of HIV. The findings are reported in the October 28 issue of the international journal AIDS. The researchers also added that the findings hold potential for finding new ways of preventing AIDS and other infections in the body.

With the lining of the mouth constantly under attack by a barrage of bacteria that commensally lives and grows in the mouth, the lining of the oral cavity has put up an innate and formidable defense line of peptides called human beta defensins 2 and 3 (hBD2 and hBD3) that may prevent humans from getting sick and may promote rapid healing from food abrasions or accidental bites to the tongue and mouth.

"It is the unique properties of the good bugs found in the mouth that are inducing the expression of hBD2 and 3," stated Aaron Weinberg, director of research at the Case School of Dentistry. The study, entitled "Human Epithelial Beta Defensins 2 and 3 Inhibit HIV-1 Replication," was the result of a 12-member research team, including Michael Lederman, an internationally known AIDS researcher from the Case School of Medicine, and Miguel E. Quinones-Mateu, the first author on the paper and a virologist from the Lerner Research Center at the Cleveland Clinic Foundation. Their recent discovery, which went on the fast track for publication in AIDS is the result of funding from a National Institute of Health-funded study on oral defenses against AIDS, of which Dr. Weinberg is the principal investigator.

The discovery suggest that the small peptides produced by cells lining the oral cavity bind to the viral particles directly and can even regulate important receptors the virus uses to infect human cells.

Since the 1990s, Aaron Weinberg, a dentist and microbiologist at the Case School of Dentistry, has been studying the natural defenses found in the mouth and how they react to bacte
'"/>

Contact: Susan Griffith
sbg4@case.edu
216-368-1004
Case Western Reserve University
28-Oct-2003


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Case researchers discover the mouth defenses against AIDS

(Date:4/18/2014)... have used techniques like X-ray crystallography and nuclear magnetic ... atomic structure of molecules, but such efforts have long ... quantities of a specific molecule and often in ordered ... all but impossible to peer into the structure of ... may soon be a thing of the past. ...
(Date:4/18/2014)... as soon as they,re planted may be good news for ... In the wild, a plant whose seeds sprouted at the ... than just an insurance policy against late frosts or unexpected ... advantages too: Plants whose seeds put off sprouting until ... in a team of researchers working at the National Evolutionary ...
(Date:4/17/2014)... A drug under clinical trials to treat tuberculosis ... drugs that act against various bacteria, fungal infections and ... University of Illinois chemists and collaborators. , Led by ... determined the different ways the drug SQ109 attacks the ... target other pathogens from yeast to malaria and ...
Breaking Biology News(10 mins):MRI, on a molecular scale 2MRI, on a molecular scale 3Plants with dormant seeds give rise to more species 2Multitarget TB drug could treat other diseases, evade resistance 2
(Date:1/14/2014)... January 14, 2014 EquitiesIQ, a leading ... (OTCQB: ALQA). Alliqua is an emerging biomedical company acquiring, ... wound care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... a seasoned management team and Board, which launched the ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ...
(Date:1/14/2014)... 2014 BioMedomics, Inc. , a Point ... platforms and novel disease specific POC tests, announced today that ... a total of $690,000. The investment is from private investors ... This group of private investors has significant successful experience in ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2BioMedomics, Inc. Closes $690K Round of Financing 2
Cached News: