HOME >> BIOLOGY >> NEWS
Case researchers discover the mouth's defenses against AIDS

Researchers at Case Western Reserve University and the Cleveland Clinic have discovered a way that the mouth may prevent the contraction of HIV. The findings are reported in the October 28 issue of the international journal AIDS. The researchers also added that the findings hold potential for finding new ways of preventing AIDS and other infections in the body.

With the lining of the mouth constantly under attack by a barrage of bacteria that commensally lives and grows in the mouth, the lining of the oral cavity has put up an innate and formidable defense line of peptides called human beta defensins 2 and 3 (hBD2 and hBD3) that may prevent humans from getting sick and may promote rapid healing from food abrasions or accidental bites to the tongue and mouth.

"It is the unique properties of the good bugs found in the mouth that are inducing the expression of hBD2 and 3," stated Aaron Weinberg, director of research at the Case School of Dentistry. The study, entitled "Human Epithelial Beta Defensins 2 and 3 Inhibit HIV-1 Replication," was the result of a 12-member research team, including Michael Lederman, an internationally known AIDS researcher from the Case School of Medicine, and Miguel E. Quinones-Mateu, the first author on the paper and a virologist from the Lerner Research Center at the Cleveland Clinic Foundation. Their recent discovery, which went on the fast track for publication in AIDS is the result of funding from a National Institute of Health-funded study on oral defenses against AIDS, of which Dr. Weinberg is the principal investigator.

The discovery suggest that the small peptides produced by cells lining the oral cavity bind to the viral particles directly and can even regulate important receptors the virus uses to infect human cells.

Since the 1990s, Aaron Weinberg, a dentist and microbiologist at the Case School of Dentistry, has been studying the natural defenses found in the mouth and how they react to bacte
'"/>

Contact: Susan Griffith
sbg4@case.edu
216-368-1004
Case Western Reserve University
28-Oct-2003


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... (PRWEB) , ... October 09, ... ... published on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s ... the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using ...
(Date:10/7/2017)... ... October 06, 2017 , ... Phase ... metagenome deconvolution product, featuring the first commercially available Hi-C kit. Researchers can ... Hi-C metagenome deconvolution using their own facilities, supplementing the company’s full-service ProxiMeta ...
(Date:10/6/2017)... , ... October 06, 2017 , ... ... within the healthcare and technology sector at their fourth annual Conference where founders, ... 30 inspiring speakers and the ELEVATE pitch competition showcasing early stage digital health ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the leading provider ... the world, is giving back to cancer research with a month-long promotion supporting the ... through October 31, shoppers can use promo code PinkRibbon to get 10 percent off ...
Breaking Biology Technology:
Cached News: