Cedars-Sinai Medical Center Physicians And Scientists Present Findings At Annual Meeting Of The Pediatric Academic Societies

ation -- was introduced, the increases in cell viability and proliferation stopped.

Furthermore, the added magnesium appeared to boost wortmannin's ability to cause cell disintegration. This suggests that the addition of extracellular magnesium causes cells to be more dependent on certain "growth factors" that need PI3 Kinase to function. Growth factors are proteins that are involved in cellular responses to growth hormone.

In addition to having at least an indirect role in activating PI3 Kinase, the addition of magnesium activates Akt, an anti-apoptotic kinase that is activated "downstream" from PI3 Kinase.

With this research, increased extracellular magnesium has for the first time been shown to increase cell proliferation in neural cells in culture. This is also the first study to suggest that increased extracellular magnesium may alter the regulation of PI3 Kinase.

The presentation is titled "Increased Extracellular Magnesium Increases Cellular Viability and Cellular Proliferation in Primary Cell Culture of Embryonic Chick Telencephalon: Mechanisms of Magnesium's Action."

The second lecture began at 2:45 p.m. Sunday, May 2. Moshe Arditi, M.D., director of the Division of Pediatric Infectious Diseases, presented a study titled "Bacterial Lipopolysaccharide (LPS) Activates NF-kappa B through Interleukin-1 (IL-1) Signaling Mediators in Cultured Human Endothelial Cells and Mononuclear Phagocytes."

For years, doctors and scientists have sought to understand a complicated mechanism that triggers an over-aggressive immune response in many patients who suffer from severe microbial infections. This immune system overreaction often leads to septic shock, for which no reliable treatments have been found.

Cases of septicemia caused by bacteria that fall into the "Gram-negative" classification have been particularly perplexing. Gram-negative organisms cause about half of all cases of septicemia, a bacterial infection that invades the bloodstream

Contact: Sandra Van
Cedars-Sinai Medical Center

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