An ideal anti-cancer agent would halt the uncontrolled growth or proliferation of abnormal cells while at the same time selectively promoting apoptosis or programmed cell death, said Rifat Pamukcu, M.D., chief scientific officer of Cell Pathways, Inc. This research demonstrates that CP461 acts against cancer cells selectively through both those mechanisms in unison, not only in cancer cells grown in the laboratory but also in a relevant animal model of human NSCLC. Moreover, this compound prevents new blood vessel formation (anti-angiogenic activity) in preclinical models even in the presence of growth stimulators like VEGF. Preventing such new blood vessel formation is also an anti-proliferative effect with potential utility in cancer treatment.
Cell Pathways is currently conducting Phase I/II clinical investigations with CP461 as a single-agent in a variety of cancer indications. Ongoing studies include clinical trials in chronic lymphocytic leukemia, hormone-refractory prostate cancer and advanced kidney cancer.
Potential Single-Agent Activi
Contact: Joan Kureczka