HOME >> BIOLOGY >> NEWS
Cell density determines extent of damage caused by cigarette smoke exposure

BETHESDA, MD First- or second-hand exposure to cigarettes can lead to a variety of diseases, including tissue destruction found in pulmonary emphysema and osteoporosis. Also included among cigarette smoking-induced diseases are disorders in which an excessive deposition of fibrotic scar occurs, such as with atherosclerosis and idiopathic pulmonary fibrosis.

Collagen is the major protein of the white fibers found in connective tissue, cartilage, and bone. It comprises a family of genetically distinct molecules, all of which have a unique triple helix configuration of three polypeptide subunits known as chains. At least 13 types of collagen have been identified, each with a different polypeptide chain. Fibroblasts, spindle-shaped cells with cytoplasmic processes present in connective tissue, are capable of forming collagen fibers. The effect of smoking on this physiological process is undetermined.

The Study
A new study has sought to determine whether the effects of cigarette smoke on the contraction of fibroblast-populated collagen gels is dependent on cell density. This research attempted to demonstrate density-dependent effects, and explore the mechanisms by which smoke exerts differential effects by determining the effect of cigarette smoke exposure (CSE) on the release of transforming growth factor and PGE2, mediators that possibly function as local regulators of collagen gel contraction.

The authors of the study, Effect of Cigarette Smoke on Fibroblast-mediated Gel Contraction is Dependent on Cell Density, are Hangjun Wang, from Mount Sinai Hospital, Toronto, Canada; Xiangde Liu, Fu-Qiang Wen, Debra J. Romberger, John R. Spurzem, and Stephen I. Rennard, from the University of Nebraska Medical Center, Omaha, NE; Takeshi Umino from Tokyo Medical and Dental University, Japan; Tadashi Kohyama, Department of Respiratory Medicine, University of Tokyo, Japan; Yun Kui Zhu, Department of Respiratory Diseases, Jincheng Hospital,
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
12-Feb-2003


Page: 1 2 3 4

Related biology news :

1. Winning combination to build bone density in children
2. Carnivore extinction risk determined more by biology than human population density, says study
3. High-density storage of nuclear waste heightens terrorism risks
4. Study: Isoflavone-enriched soy proteins fail to increase bone mineral density in young women
5. Researchers determine the influence of bone density results in adolescents with anorexia
6. Researchers discover thermostat that regulates bone density
7. Variations in food density affect calorie consumption
8. Animals regulate their numbers by own population density
9. Moderate alcohol consumption increases bone mineral density in elderly women
10. Aslera™ improves bone mineral density in lupus patients
11. Obese as likely as lean women to feel full on low energy density meals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... Calif. (PRWEB) , ... August 19, 2020 , ... ... both Salimetrics LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for more ... of the recently published book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary ...
(Date:8/12/2020)... ... 2020 , ... Mosio recently announced its newly updated text ... of all sizes. With a focus on tracking symptoms and monitoring outbreaks as ... Mosio helps public health departments automate communications and provide more personalized care and ...
(Date:8/3/2020)... ... 03, 2020 , ... Accumen Inc. is helping healthcare get ... Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has ... than 10 years. Early in the COVID-19 crisis, we identified supply chain gaps ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... ... True Terpenes , the leading platform for terpene innovation, research and development, ... medical potential of terpenes and the potential entourage effect , where the benefits ... on expanding the recently launched line of effects-based terpenes - Terpology by Dr. ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... available for free its new white paper – Simulated Transport Methodologies. Regulatory ... today’s biologics licensing application (BLA). In response, Modality Solutions shares an explanation ...
(Date:8/3/2020)... ... 03, 2020 , ... ERT, the global leader ... been named one of the 100 most inspiring individuals in the life-sciences industry ... selected based on how they have inspired their colleagues and affected positive changes ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader ... tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at a time ... track capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical ...
Breaking Biology Technology:
Cached News: