HOME >> BIOLOGY >> NEWS
Cell division required, twice before fat cells mature

Johns Hopkins School of Medicine scientists have shown for the first time that primitive fat cells must copy themselves at least twice before they can mature into full-fledged fat-storing cells. The finding, published online the week of Dec. 23 in the Proceedings of the National Academy of Sciences, may help provide new targets for understanding and treating obesity.

The finding also helps explain how the body ensures that it can always store fat, a key to surviving when food is scarce (and an unfortunate ability when it is not). By requiring a primitive fat cell to copy itself at least twice before it matures and can't divide anymore, nature ensures a ready reservoir of the cells, say the researchers. While proliferation of these cells has long been recognized, this is the first evidence that those divisions are necessary for the cells' maturation.

"Fortunately or unfortunately, depending on how you look at it, food is not scarce in many parts of the world, and storing the excess calories can lead to obesity and many serious associated health problems," notes Daniel Lane, Ph.D., professor of biological chemistry at the school's Institute for Basic Biomedical Sciences. "Our finding may lead to new ways to tackle obesity, since we now know a crucial step in the body's ability to store additional fat, but that step would have to be targeted specifically."

Studying mouse primitive fat cells in the laboratory, the team discovered that the genes necessary for storing fat were turned on only after at least two cycles of cell division. Interfering with cell division at various points in the cycle prevented the cells from maturing, says Qi-Qun Tang, M.D., Ph.D., assistant professor of pediatric endocrinology and biological chemistry at Hopkins.

When more calories are taken in than are burned, existing fat cells make and store more fat. But the body also recruits some primitive fat cells -- preadipocytes to mature, which increases the capaci
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
23-Dec-2002


Page: 1 2

Related biology news :

1. Synthesized molecules studied as weapon to stop cell division in cancer cells
2. UCSD study shows how we perceive world depends on precise division of labor among cells in brain
3. UW-Madison scientists find a key to cell division
4. Cell division can be halted in multiple ways, with implications for cancer
5. UVa researchers describe method of protecting chromosomes during cell division
6. Protein involved in cell division now found key to cell growth
7. UGA research team reveals molecular key to cell division
8. Mathematical prediction of on-off switches in cell division proven
9. Chromatin, not proteins, support chromosomes during cell division
10. Essential cell division zipper anchors to so-called junk DNA
11. Virginia Tech researchers receive $450,000 award to model cell division

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cell division required twice before fat cells mature

(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/18/2014)... BETHESDA, Md. , Nov. 17, 2014 The ... European and U.S. regulatory agencies will speak and at least ... Quality Metrics Conference at the Omni Shoreham Hotel in ... is pleased once again to have significant support from the ... and Europe in our effort to ...
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
(Date:12/19/2014)... REDWOOD CITY, Calif. , Dec. 19, 2014 ... , USA) announced today that they have been ... Technologies 1,2 is a privately held company that ... processing of next generation sequencing (NGS) data for the ... into the Roche Sequencing Unit, and will continue to ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fhh9rj/technology ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research Service ... detailed assessment on technological advancements and market for ... 1. The Smart Fabrics market is expected ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 Today, ... locate its pilot production facility and future company ... and produce innovative new materials that safely and ... not only because of its historic, strong support ... efforts to attract leading edge, technology-based companies such ...
(Date:12/19/2014)... Ed Bilsky, Ph.D., vice president for Research and ... the Neurosciences (CEN), and professor of pharmacology at the ... member of the prestigious Dana Alliance for Brain Initiatives ... receive this honor. , The Dana Alliance ... Foundation. Its mission is to advance public education ...
Breaking Biology Technology:Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3Technology Innovations in Smart Fabrics (Technical Insights) 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3
Cached News: