Cell division required, twice before fat cells mature

Johns Hopkins School of Medicine scientists have shown for the first time that primitive fat cells must copy themselves at least twice before they can mature into full-fledged fat-storing cells. The finding, published online the week of Dec. 23 in the Proceedings of the National Academy of Sciences, may help provide new targets for understanding and treating obesity.

The finding also helps explain how the body ensures that it can always store fat, a key to surviving when food is scarce (and an unfortunate ability when it is not). By requiring a primitive fat cell to copy itself at least twice before it matures and can't divide anymore, nature ensures a ready reservoir of the cells, say the researchers. While proliferation of these cells has long been recognized, this is the first evidence that those divisions are necessary for the cells' maturation.

"Fortunately or unfortunately, depending on how you look at it, food is not scarce in many parts of the world, and storing the excess calories can lead to obesity and many serious associated health problems," notes Daniel Lane, Ph.D., professor of biological chemistry at the school's Institute for Basic Biomedical Sciences. "Our finding may lead to new ways to tackle obesity, since we now know a crucial step in the body's ability to store additional fat, but that step would have to be targeted specifically."

Studying mouse primitive fat cells in the laboratory, the team discovered that the genes necessary for storing fat were turned on only after at least two cycles of cell division. Interfering with cell division at various points in the cycle prevented the cells from maturing, says Qi-Qun Tang, M.D., Ph.D., assistant professor of pediatric endocrinology and biological chemistry at Hopkins.

When more calories are taken in than are burned, existing fat cells make and store more fat. But the body also recruits some primitive fat cells -- preadipocytes to mature, which increases the capaci

Contact: Joanna Downer
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. Synthesized molecules studied as weapon to stop cell division in cancer cells
2. UCSD study shows how we perceive world depends on precise division of labor among cells in brain
3. UW-Madison scientists find a key to cell division
4. Cell division can be halted in multiple ways, with implications for cancer
5. UVa researchers describe method of protecting chromosomes during cell division
6. Protein involved in cell division now found key to cell growth
7. UGA research team reveals molecular key to cell division
8. Mathematical prediction of on-off switches in cell division proven
9. Chromatin, not proteins, support chromosomes during cell division
10. Essential cell division zipper anchors to so-called junk DNA
11. Virginia Tech researchers receive $450,000 award to model cell division

Post Your Comments:

(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... NC (PRWEB) , ... June 23, 2016 , ... In ... University Hospital in Denmark detail how a patient who developed lymphedema after being treated ... tissue. The results could change the paradigm for dealing with this debilitating, frequent side ...
(Date:6/23/2016)... June 23, 2016 On Wednesday, June ... 4,833.32, down 0.22%; the Dow Jones Industrial Average edged 0.27% ... at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the ... Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. ... BIND ). Learn more about these stocks by ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... the QB3@953 life sciences incubator to accelerate ... The shared laboratory space at QB3@953 was created to ... key obstacle for many early stage organizations - access ... the sponsorship, Amgen launched two "Amgen Golden Ticket" awards, ...
Breaking Biology Technology:
Cached News: