HOME >> BIOLOGY >> NEWS
Cell growth and death controlled by single pathway in lymphoma cancer model

New research at Rockefeller University, published this week in the online edition of the Proceedings of the National Academy of Sciences, helps explain why some people do not respond to chemotherapy and offers a possible solution.

The cell culture study shows that in a type of lymphoma, molecules involved in the NF-kappa B (NF-kB) signaling pathway -- responsible for pushing cells to grow uncontrollably -- also control the function of the p53 tumor suppressor protein whose function is demolishing those harmful cells. The same interactions could characterize other cancer types, the researchers say.

Most chemotherapy target what was thought to be a discrete "pathway" responsible for cell destruction, such as the p53 protein, but if these proteins are managed -- even protected -- by other key cancer-promoting molecules, the chemotherapy will not work.

Instead, the researchers say it may be possible to target one or both of the genes they found that link both molecular pathways, like intersections joining two highways together in different spots.

"Now that we know the proliferation pathway can jam the p53 suicide pathway, we might be able to block specific sections of those pathways," says the lead researcher, Archontoula Stoffel, Ph.D., a research assistant professor at Rockefeller University.

Blocking only selected pieces of these pathways will be important, Stoffel says, because the NF-kappa B pathway plays a vital role in the body's normal immune and inflammatory responses, although it is also linked to a growing list of cancers. "It is not possible to shut down NF-kB without causing systemic problems, so we need to find out how to disarm its carcinogenic properties down the signaling pathway, while maintaining its useful functions," she says. "This study may help."

The study also is important because it presents the first molecular description of a cancer caused by bacteria, and thus "represents a model system of ho
'"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
31-May-2004


Page: 1 2 3 4

Related biology news :

1. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
2. New Arizona State center brings science to policy on issues of water resources and urban growth
3. Researchers identify protein promoting vascular tumor growth
4. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
5. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
6. Extreme stretch-growth of axons
7. Diabodies act as guided missiles targeted to mammary tumor growth
8. Study reveals first genetic step necessary for prostate cancer growth
9. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
10. T. rex owes its giant size to the ultimate teenage growth spurt
11. Two-pronged attack targeting EGF receptor hinders cancer cell growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They ... a complex biological network, a depiction of a system of linkages and connections ... Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) and ...
(Date:10/12/2017)... , ... October 12, 2017 ... ... announces publication of a United States multicenter, prospective clinical study that demonstrates ... point-of-care diagnostic test capable of identifying clinically significant acute bacterial and viral ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the first-ever genomics analysis platform specifically designed for life science researchers to ... of pioneering researcher Rosalind Franklin, who made a major contribution to the ...
(Date:10/11/2017)... ... ... wash is a basic first aid supply for any work environment, but most personal eye ... first if a dangerous substance enters both eyes? It’s one less decision, and likely quicker ... eye piece. , “Whether its dirt and debris, or an acid or alkali, getting anything ...
Breaking Biology Technology:
Cached News: