HOME >> BIOLOGY >> NEWS
Cell studies may further gene therapy prospects for head and neck cancer

CHAPEL HILL - New laboratory research at the University of North Carolina appears to kindle prospects of finding ways to treat head and neck cancer with gene therapy.

The study published November 20 in the journal Human Gene Therapy suggests that gene therapy techniques may be developed to preferentially target cancer cells or pre-cancerous cells that are at high risk for becoming malignant.

"Right now there's no clinical application of our work in human gene therapy, but findings from our tissue culture model suggest there may be," said Wendell G. Yarbrough, MD, assistant professor of otolaryngology/head and neck surgery at UNC-CH School of Medicine and Hospitals.

The Carolina researcher, a member of the UNC Lineberger Comprehensive Cancer Center, said he and his collaborators developed a tissue culture system that mimicked how normal cells grow in the body. Using cultured cells, they created models that mimicked the three-dimensional structure of head and neck epithelium, the normal tissue that lines the inside of humans' mouths and throats. This allowed a more realistic investigation of a widely studied gene transfer technique that uses a common cold virus - adenovirus - to infect cells and deliver therapeutic payloads.

"If you take cells out of the body and put them in tissue culture, they typically grow as a monolayer, one cell layer thick," Yarbrough explained. "But that's not the way they are in the body. These can be infected by adenoviruses very easily. "But if you let cells start piling up on each other and differentiating the way they do in the body, then it's very hard to infect them."

Now it appears that the reason for that is linked to whether or not the cells show gene expression of a specific protein, a receptor site known as hCAR, human coxsackie and adenovirus receptor.

"And that's what we found. We correlated the ability of cells to be infected by adenovirus with the expression of hCAR, a receptor
'"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
19-Nov-2000


Page: 1 2 3

Related biology news :

1. Rensselaer marks the opening of the center for biotechnology and interdisciplinary studies
2. UCSD undergraduates participate in collaborative studies abroad on cyberinfrastructure
3. Scientist honored for studies of genetic influence on chemotherapy, tumor development
4. $5 million grant funds partnership, studies of minority-based issues in reproductive health
5. Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
6. $5.5 million awarded to tree-ring research and climate studies
7. Pancreatic cancer blood test & gene studies show promise
8. Two studies weigh in on low-carb diets
9. Animal studies show promise treating severe chronic pain
10. New studies show Curves Program raises metabolic rate in overweight and sedentary women
11. Florida Tech researchers win $912,700 grant for cell studies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: