HOME >> BIOLOGY >> NEWS
Cells Keep Bad Guys In A Cage Until They Are Fit To Socialize

Researchers at the Max Planck Institute for Biochemistry in Martinsried/Germany found that the cage structure of the chaperonin GroEL is essential for cellular protein folding (Nature Structural Biology, Vol. 5, Number 11, November 1998). Enclosure of an unfolded protein in the cage provided by the oligomeric GroEL protein efficiently prevents protein aggregation during folding. This is particularly critical for aggregation sensitive proteins (the bad guys) that expose significant hydrophobic surfaces to the solvent. In contrast to earlier proposals, repeated unfolding of partially folded polypeptides is not an essential part of this mechanism.

In the November issue of Nature Structural Biology (page 977-985), the authors Frank Weber, Manjit Hayer-Hartl and Franz-Ulrich Hartl report a study showing that "The oligomeric structure of GroEL-GroES is required for biologically significant chaperonin function in protein folding". This study includes in vivo complementation studies performed by the co-authors France Keppel and Costa Georgopoulos from the University of Geneva, Centre Medical Universitaire (Switzerland).

Chaperonins have been found in all cells investigated to date including organelles like mitochondria and chloroplasts. The Escherichia coli chaperonin GroEL is encoded by an essential gene and consists of 14 identical subunits. These subunits are arranged in two heptameric rings which are stacked back-to-back. Each ring encloses a central cavity in which substrate polypeptide is bound by interaction with the apical domains of the GroEL monomers, which form the opening of the cylinder. After substrate is bound inside the cavity, GroES, a dome-shaped heptameric complex, closes the opening of the ring and causes the release of unfolded substrate polypeptide into the central cavity. In this enclosed environment, the substrate can fold to its native state. It is subsequently released into the cytosol upon ATP-dependent dissociation of GroES from GroEL.
'"/>

Contact: Franz-Ulrich Hartl
uhartl@biochem.mpg.de
49-89-8578-2244
Max-Planck-Gesellschaft
6-Nov-1998


Page: 1 2 3

Related biology news :

1. Cells may shoot messenger to halt protein production
2. Cells from adult bone marrow can be converted into brain stem cells for transplantation
3. Cells ability to open bloods floodgates hinges on unexpected factors
4. Cells ability to live without oxygen give clues for treating major diseases
5. Cells use patch to heal tears, avoid destruction and disease
6. Food for thought: Cells dine on their own brains to stay fit and trim
7. Cells in patients noses hold potential to restore function in spinal cord injury
8. Cells on the verge of suicide
9. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
10. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate
11. Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... , Feb. 22, 2017 With the ... ABI Research identifies four technologies that innovative and ... secure significant share in the changing competitive landscape: ... passive authentication.   "Companies can no ... to security," says Dimitrios Pavlakis , Industry ...
(Date:2/21/2017)... 21, 2017 Der weltweite Biobanking-Sektor ... Nach einem Gespräch mit mehr als 50 Vertretern aus verschiedenen ... überwinden gilt, um diese Prognose zu realisieren. ... Zu ... der finanziellen Mittel für die Biobank, die Implementierung Zeit ...
(Date:2/14/2017)... WINSTON-SALEM, N.C. , Feb. 14, 2017  Wake ... FRY-shlog), M.D., as its new chief executive officer (CEO). ... succeeds CEO John D. McConnell , M.D., who ... new position at the Medical Center, after leading it ... oversee the full scope of Wake Forest Baptist,s academic ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... -- On Thursday, March 23, 2017, the ... 0.07%; the Dow Jones Industrial Average edged 0.02% lower, ... at 2,345.96, marginally dropping 0.11%. US markets saw a ... sectors finished in red, and 1 sector ended flat ... coverage on the following Biotechnology equities: BioDelivery Sciences International ...
(Date:3/24/2017)... 2017 Agenus Inc. (NASDAQ: AGEN), an immuno-oncology ... cancer vaccines, today announced participation at the following conferences: ... Blair and Maidstone Life Sciences conference "Cancer Immunotherapy Conference" ... New York, NY . Agenus will participate ... 9:40 am: Robert B. Stein , M.D., Ph.D., ...
(Date:3/23/2017)... ... ... to announce it has become the premiere team-building cooking event company in San Diego. ... as Illumina, HP and Qualcomm, and is ranked #1 in its category on Trip Advisor. ... new team building format, a way for teams to not only interact with one another ...
(Date:3/23/2017)... 23, 2017  Northwest Biotherapeutics (OTCQB: NWBO) (NW ... therapies for solid tumor cancers, today announced that ... it announced last Friday, March 17, 2017. ... investors securities totaling 28,843,692 shares, comprised of 18,843,692 ... shares of Class C Warrants pre-funded at the ...
Breaking Biology Technology:
Cached News: