HOME >> BIOLOGY >> NEWS
Cells Keep Bad Guys In A Cage Until They Are Fit To Socialize

Researchers at the Max Planck Institute for Biochemistry in Martinsried/Germany found that the cage structure of the chaperonin GroEL is essential for cellular protein folding (Nature Structural Biology, Vol. 5, Number 11, November 1998). Enclosure of an unfolded protein in the cage provided by the oligomeric GroEL protein efficiently prevents protein aggregation during folding. This is particularly critical for aggregation sensitive proteins (the bad guys) that expose significant hydrophobic surfaces to the solvent. In contrast to earlier proposals, repeated unfolding of partially folded polypeptides is not an essential part of this mechanism.

In the November issue of Nature Structural Biology (page 977-985), the authors Frank Weber, Manjit Hayer-Hartl and Franz-Ulrich Hartl report a study showing that "The oligomeric structure of GroEL-GroES is required for biologically significant chaperonin function in protein folding". This study includes in vivo complementation studies performed by the co-authors France Keppel and Costa Georgopoulos from the University of Geneva, Centre Medical Universitaire (Switzerland).

Chaperonins have been found in all cells investigated to date including organelles like mitochondria and chloroplasts. The Escherichia coli chaperonin GroEL is encoded by an essential gene and consists of 14 identical subunits. These subunits are arranged in two heptameric rings which are stacked back-to-back. Each ring encloses a central cavity in which substrate polypeptide is bound by interaction with the apical domains of the GroEL monomers, which form the opening of the cylinder. After substrate is bound inside the cavity, GroES, a dome-shaped heptameric complex, closes the opening of the ring and causes the release of unfolded substrate polypeptide into the central cavity. In this enclosed environment, the substrate can fold to its native state. It is subsequently released into the cytosol upon ATP-dependent dissociation of GroES from GroEL.
'"/>

Contact: Franz-Ulrich Hartl
uhartl@biochem.mpg.de
49-89-8578-2244
Max-Planck-Gesellschaft
6-Nov-1998


Page: 1 2 3

Related biology news :

1. Cells may shoot messenger to halt protein production
2. Cells from adult bone marrow can be converted into brain stem cells for transplantation
3. Cells ability to open bloods floodgates hinges on unexpected factors
4. Cells ability to live without oxygen give clues for treating major diseases
5. Cells use patch to heal tears, avoid destruction and disease
6. Food for thought: Cells dine on their own brains to stay fit and trim
7. Cells in patients noses hold potential to restore function in spinal cord injury
8. Cells on the verge of suicide
9. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
10. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate
11. Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cells Keep Bad Guys Cage Until They Are Fit Socialize

(Date:3/30/2015)... DUBLIN , Mar. 26, 2015 Research and ... addition of the "Global Gesture Recognition Market in ... The analysts forecast the Global Gesture Recognition market ... 12.8% over the period 2013-2018. Gesture recognition ... respond to different gestures of an individual. Gesture recognition ...
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... critical security-authentication needs, today announced the beginning of shipments ... solution. The company, based in ... the three-day Connect:ID Expo, which began here today at ... said version 2.0 of its SDK boosts the accuracy ...
(Date:3/23/2015)...  In the 2014 fiscal year, irs.gov recorded over ... figure accounts for a fraction of the estimated losses ... exceeds $11 billion globally. The polygraph has traditionally been ... occurred. Investor Mark Saint Juste along with ... partnered to administer the test in a new ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
(Date:5/1/2015)... 2015 Pfenex Inc. (NYSE MKT: PFNX), ... of biosimilar therapeutics including high value and difficult ... quarter 2015 financial results will be released on ... market. At 8:30 am Eastern Time, Pfenex management will ... results and provide a business update. A press release ...
(Date:5/1/2015)... 1, 2015 According to ... Product (Equipment, Consumables), by Type (Monoclonal, Polyclonal), by ... Research Institutes) - Analysis & Global Forecast to ... global Antibody Production Market for the forecast period ... to reach $2.572 Billion by 2019 from $1.425 ...
(Date:4/30/2015)... Francisco, CA (PRWEB) April 30, 2015 Cytokinetics, ... the first quarter of 2015 were $4.4 million, compared to ... net loss for the first quarter was $8.9 million, or ... a net loss for the same period in 2014, of ... As of March 31, 2015, cash, cash equivalents and investments ...
(Date:4/30/2015)... 30, 2015 Biodata, producer of ... integrated protocols and specimen management systems, and ChemAxon, ... consulting services for life science research, announce their ... newest feature: chemical structure and reaction support. Already ... biologists, bio-chemists, and more, the integration of ChemAxon's ...
Breaking Biology Technology:Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8Labguru Integrates ChemAxon's Marvin JS, to Enhance Functionality for Chemists 2
Cached News: