HOME >> BIOLOGY >> NEWS
Cells Keep Bad Guys In A Cage Until They Are Fit To Socialize

Researchers at the Max Planck Institute for Biochemistry in Martinsried/Germany found that the cage structure of the chaperonin GroEL is essential for cellular protein folding (Nature Structural Biology, Vol. 5, Number 11, November 1998). Enclosure of an unfolded protein in the cage provided by the oligomeric GroEL protein efficiently prevents protein aggregation during folding. This is particularly critical for aggregation sensitive proteins (the bad guys) that expose significant hydrophobic surfaces to the solvent. In contrast to earlier proposals, repeated unfolding of partially folded polypeptides is not an essential part of this mechanism.

In the November issue of Nature Structural Biology (page 977-985), the authors Frank Weber, Manjit Hayer-Hartl and Franz-Ulrich Hartl report a study showing that "The oligomeric structure of GroEL-GroES is required for biologically significant chaperonin function in protein folding". This study includes in vivo complementation studies performed by the co-authors France Keppel and Costa Georgopoulos from the University of Geneva, Centre Medical Universitaire (Switzerland).

Chaperonins have been found in all cells investigated to date including organelles like mitochondria and chloroplasts. The Escherichia coli chaperonin GroEL is encoded by an essential gene and consists of 14 identical subunits. These subunits are arranged in two heptameric rings which are stacked back-to-back. Each ring encloses a central cavity in which substrate polypeptide is bound by interaction with the apical domains of the GroEL monomers, which form the opening of the cylinder. After substrate is bound inside the cavity, GroES, a dome-shaped heptameric complex, closes the opening of the ring and causes the release of unfolded substrate polypeptide into the central cavity. In this enclosed environment, the substrate can fold to its native state. It is subsequently released into the cytosol upon ATP-dependent dissociation of GroES from GroEL.
'"/>

Contact: Franz-Ulrich Hartl
uhartl@biochem.mpg.de
49-89-8578-2244
Max-Planck-Gesellschaft
6-Nov-1998


Page: 1 2 3

Related biology news :

1. Cells may shoot messenger to halt protein production
2. Cells from adult bone marrow can be converted into brain stem cells for transplantation
3. Cells ability to open bloods floodgates hinges on unexpected factors
4. Cells ability to live without oxygen give clues for treating major diseases
5. Cells use patch to heal tears, avoid destruction and disease
6. Food for thought: Cells dine on their own brains to stay fit and trim
7. Cells in patients noses hold potential to restore function in spinal cord injury
8. Cells on the verge of suicide
9. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
10. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate
11. Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... Tunnell Consulting ... sessions at the ISPE Annual Meeting and Expo , to be held October ... The event’s theme is “Driving innovation to advance patient therapies.” , The ISPE Annual ...
(Date:8/16/2017)... ... August 16, 2017 , ... Today, 3Bar Biologics ... secured $2M in funding from an impressive group of investors, including Rev1 Ventures, ... Fund. With this investment, 3Bar is broadening availability of its groundbreaking offering that ...
(Date:8/15/2017)... After spending the past two years building a state-of-the-art technology which ... offers this platform to healthcare stakeholders (hospitals, foundations, biopharma companies etc.) ... collection vis a vis their members, under their own brand. Three ... offer. ... ...
(Date:8/15/2017)... ... August 15, 2017 , ... Any expert in stem cell research or ... for more than half a century. Despite their essential roles in human health ... known that molecular tags developed for this purpose also tag other, more abundant, non-stem ...
Breaking Biology Technology:
Cached News: