HOME >> BIOLOGY >> NEWS
Cells may shoot messenger to halt protein production

COLUMBUS, Ohio Scientists have found that living cells will sometimes "shoot the messenger" as a way to halt production of certain proteins.

The study, published in the May 21 issue of the journal Molecular Cell, shows that cells sometimes destroy the chemical messages that contain information for making proteins even as the messages are being "read." The work was done by scientists at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

The findings describe a poorly understood biochemical mechanism that cells may use to suddenly stop producing proteins like growth factors that activate genes in response to a hormone or other signaling chemical. The mechanism also plays a key role in Cooley's anemia, which causes the loss of red blood cells in infants and children, and may contribute to changes in gene activation in cancer.

The mechanism involves a recently discovered enzyme that destroys the ribbon-like molecules of messenger RNA (mRNA). Messenger RNA is a copy of gene, and it contains information that describes the structure of a protein. It carries that information from genes in the cell nucleus to the region of the cell where proteins are made.

"Controlling mRNA degradation is one of the key ways that cells regulate how much of a particular protein they produce," says senior author Daniel R. Schoenberg, professor of molecular and cellular biochemistry. "The mechanism we describe is a completely new concept in the field."

Proteins carry out most of the work in cells. Production of a protein begins when the gene carrying the information for a protein opens -- the DNA unwinds -- and the information is copied in the form of another molecule, mRNA.

Next, the mRNA leaves the cell nucleus and enters the cell cytoplasm. There, complexes known as ribosomes attach to one end of the mRNA.

The ribosomes then travel along the mRNA, reading th
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
20-May-2004


Page: 1 2

Related biology news :

1. Cells from adult bone marrow can be converted into brain stem cells for transplantation
2. Cells ability to open bloods floodgates hinges on unexpected factors
3. Cells ability to live without oxygen give clues for treating major diseases
4. Cells use patch to heal tears, avoid destruction and disease
5. Food for thought: Cells dine on their own brains to stay fit and trim
6. Cells in patients noses hold potential to restore function in spinal cord injury
7. Cells on the verge of suicide
8. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
9. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate
10. Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover
11. Researchers Discover How The Immune System Shuts Down Faulty T Cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... August 06, 2019 , ... A ... system that could have far-reaching implications for personalized medicine, especially when seeking treatments ... is able to predict which stem cell donors and manipulation methods might yield ...
(Date:8/4/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading experts ... so be sure to register today to save your place! Participate in the discussion ... upcoming webinars: , CLINICAL OPERATIONS , August 27 – Friend or Foe? An Assessment ...
(Date:8/1/2019)... ... 31, 2019 , ... Molecular Devices, LLC, a leader in ... of its FLIPR® Penta High-Throughput Cellular Screening System. , The new FLIPR Penta ... G-protein-coupled receptors (GPCRs) and ion channels, offering a new high-speed camera option capable ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
(Date:6/11/2019)... ... June 10, 2019 , ... DeepDyve and ... scientific journals to DeepDyve’s rental service for peer-reviewed journals. , IOPP’s portfolio ... more than 20 million articles, sourced from more than 15,000 journals. , “By ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... (PRWEB) , ... May 29, ... ... our patent applications from the USPTO providing proprietary interest to our methodology, ... FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our ...
Breaking Biology Technology:
Cached News: