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Cells on the verge of suicide

p mechanism by which survival factors suppress the apoptotic cell death program been identified," says Steller.

The scientists report that a growth factor called SPITZ binds to its receptor and triggers the activation of what is known as the RAS/MAPK pathway. This pathway, in turn, puts the brakes on Hid, which then prevents the chains on the beastly caspases from falling open, thus averting death.

The RAS/MAPK pathway plays a well-known role in cancer: it both promotes cell growth and blocks apoptosis, thereby preventing the body from eliminating, via cell death, harmful cells. Consequently, the new research has implications for the treatment of cancers in which this pathway has gone awry - in addition to a host of other cancers that have lost the protective cell death mechanism.


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Contact: Whitney Clavin
clavinw@rockefeller.edu
212-327-7250
Rockefeller University
31-Jan-2002


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