HOME >> BIOLOGY >> NEWS
Cellular Engineers Design Custom Cell Surfaces Able To Adhere To Synthetic Materials

BERKELEY, CA. -- Carolyn Bertozzi and her colleagues at the Ernest Orlando Lawrence Berkeley National Laboratory have found a way to use natural biological processes to plant artificial markers on the surfaces of living cells.

With these markers, cell surfaces can be engineered to control cell adhesion to synthetic organic polymers, metals, ceramics, and other materials used in the walls of bioreactors, and in biomedical implants such as pacemakers and artificial organs. In the future, living cells attached to electronic devices may warn of dangerous chemical or biological toxins in the environment. Already Bertozzi's group has used this cell-surface engineering to turn cancer cells into bright targets for diagnostic probes and cell-killing toxins.

"Our primary goal is to take control of the cell surface," says Bertozzi, who is a member of Berkeley Lab's Biomolecular Materials Program in the Materials Sciences Division, as well as an assistant professor of chemistry at the University of California at Berkeley. "We have begun to understand the bio-organic chemistry of cells well enough to treat cells like complex machines -- to really do cellular engineering."

All cell surfaces are decorated with oligosaccharides -- complex structures strung together inside the cell from a few simple sugars. Different kinds of cells display different oligosaccharides, and even the same kinds of cells display different patterns depending on their stage of development or environment. Since each oligosaccharide is chemically unique, each imparts to the cell a unique surface for interaction with the outside world.

"We asked ourselves, how can we exploit these differences?" says Bertozzi. Working with graduate student Lara Mahal and postdoctoral fellow Kevin Yarema, Bertozzi set out to design new cell surfaces that could stick to synthetic materials. "We decided to appropriate the cell
'"/>

Contact: Paul Preuss
paul_preuss@lbl.gov
510-486-6249
DOE/Lawrence Berkeley National Laboratory
6-Jan-1998


Page: 1 2 3 4

Related biology news :

1. Cellular problems found behind complex obesity syndrome
2. Cellular fat sensor slows heart disease
3. Cellular problem discovered behind syndrome of obesity, learning disabilities
4. Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize
5. Cellular pathway includes a clock that steers gene activity
6. Cellular organelle evolved repeatedly
7. Cellular membrane changes associated with acclimation to cold
8. Cellular espionage at play in post-menopausal osteoporosis
9. Dual Control Strategy Assures Accurate Cellular Marching Orders, But A Pathogenic Microbe Can Hijack The System
10. UC Davis Researchers Get First Look At A Working Cellular Motor
11. Cellular Target Of Leprosy, Deadly Viruses Found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... LUXEMBOURG (PRWEB) , ... August ... ... Luxembourg-based clinical-stage biotechnology company developing novel pharmaceuticals targeting mitochondria, in partnership with ... of enrolment in its pivotal U.S. Phase 3 VISTA-2 study of SkQ1 ...
(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, ... magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ranking of ... as well, and for this year’s list, reported three-year revenue growth of 71 percent. ...
(Date:8/21/2020)... ... August 18, 2020 , ... ... therapy, today announced that the U.S. Food and Drug Administration (FDA) has approved ... asset, SBI-101, for the treatment of severe COVID-19. Approval of this IND allows ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 2020 , ... eSource has long been touted as the solution to high ... eSource, the reasons it did not take off as quickly as people initially expected, ... is moving towards capturing data electronically for clinical trials and then repurposing it for ...
(Date:7/18/2020)... , ... July 16, 2020 , ... “We are thrilled ... Wave Bioactives. “It’s the only technology of its kind on the market and we ... onions with the protective capacity of traditional cultured ingredients, creating a natural way to ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most ... used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate ... Dr MA has been using the zebrafish model to investigate the causes of ...
(Date:7/1/2020)... ... 29, 2020 , ... The Interlocal Purchasing System (TIPS), a ... recently named BioFit Engineered Products an Awarded Vendor. Awarded Vendor status ... cafeteria tables, book trucks and carts at discounted pricing without the delay and ...
Breaking Biology Technology:
Cached News: