HOME >> BIOLOGY >> NEWS
Cellular espionage at play in post-menopausal osteoporosis

Bone researchers have long known that post-menopausal women are at increased risk of bone loss and diseases such as osteoporosis because of low levels of the hormone estrogen. In recent years, estrogen replacement therapy has been the course of action to prevent bone loss in such women. But not all women are acceptable candidates for this therapy because some may be predisposed to breast, uterine and ovarian cancer risks if they take increased estrogen.

Despite advances in estrogen replacement therapy, it is a source of hot debate in the biomedical community over what cell, molecular and biochemical processes are involved in bone loss associated with declining estrogen levels.

Now a group of biologists at Washington University in St. Louis has shown that lower estrogen levels in post-menopausal women allow a class of inflammatory molecules called cytokines to bind to bone cell surfaces. This in turn gives the green light for specialized cells called osteoclasts to perform their specialty -- bone resorption, or destruction. Moreover, the Washington University team headed by Philip Osdoby, Ph.D., professor of biology in Arts and Sciences, and Teresa Sunyer, Ph.D., research assistant professor of biology, has shown a new relationship between estrogen, bone cell surface receptor proteins and the cytokines Interleukin 1 (IL-1) and Interleukin 8 (IL-8).

Their findings reveal a "cellular espionage" scenario involving signaling receptor proteins and decoy receptor proteins. Osdoby, Sunyer and colleagues found that, in the presence of estrogen, decoy receptor proteins increase in bone cells, preventing cytokines from initiating the path of bone destruction. Without estrogen, signaling receptor proteins flourish and the decoys diminish, letting the osteoclasts erode bone.

The results were published in the May 15, 1999, issue of the Journal of Clinical Investigation. The research was supported by grants from the National Institutes of Health.

B
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@aismail.wustl.edu
314-935-5272
Washington University in St. Louis
26-Jul-1999


Page: 1 2 3 4

Related biology news :

1. Cellular problems found behind complex obesity syndrome
2. Cellular fat sensor slows heart disease
3. Cellular problem discovered behind syndrome of obesity, learning disabilities
4. Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize
5. Cellular pathway includes a clock that steers gene activity
6. Cellular organelle evolved repeatedly
7. Cellular membrane changes associated with acclimation to cold
8. Dual Control Strategy Assures Accurate Cellular Marching Orders, But A Pathogenic Microbe Can Hijack The System
9. UC Davis Researchers Get First Look At A Working Cellular Motor
10. Cellular Target Of Leprosy, Deadly Viruses Found
11. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cellular espionage play post menopausal osteoporosis

(Date:7/25/2014)... of Adelaide has opened the way for the development of ... In Australia, annual barley production is second only to wheat ... of the most important diseases of barley. , Senior Research ... of special growths on the cell walls of barley plants ... , The research, by the ARC Centre of Excellence in ...
(Date:7/25/2014)... at the Stowers Institute for Medical Research ... receptors, and found pheromones crucial to triggering the mating ... receptors helps a male mouse detect pheromones that indicate ... receptors lets him know if the female mouse is ... are critical to trigger mating. Stowers, researchers believe mice ...
(Date:7/24/2014)... wildlife loss leads to conflict among people around the ... Society (WCS) Health & Ecosystems: Analysis of Linkages (HEAL) ... approach to tackle global biodiversity decline. , The harvest ... world,s people and provides protein for more than a ... no surprise that today,s unprecedented loss of wildlife, is ...
Breaking Biology News(10 mins):New hope for powdery mildew resistant barley 2It takes two to court 2It takes two to court 3New study draws links between wildlife loss and social conflicts 2
(Date:7/25/2014)... /PRNewswire-iReach/ -- Xybion Corporation, the leading provider of ... in highly regulated industries, announced today that the ... Group Conference, Xybion International Exchange, on October 21-23, ... at the Sheraton Society Hill Hotel.  ... This year,s conference theme is Compliance Fusion.  ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 Gain ... Global Supply Chain of the biotech industry. Nominations ... Innovation Awards, brought to you by the ... organization of supply chain management professionals for the ... to stakeholders of the Biotech industry – Manufacturers, ...
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
(Date:7/24/2014)... -- Research and Markets has announced the ... Instruments Market 2014-2018" report to their offering. ... is the study of the gene and its functions ... functions of proteomes or sets of proteins by using ... the mapping of genes and DNA sequencing to understand ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
Cached News: