HOME >> BIOLOGY >> NEWS
Cellular problem discovered behind syndrome of obesity, learning disabilities

Many a high school biology student has glanced into a microscope to see the planet's smallest animals -- paramecium and the like -- being propelled by the waving, hair-like projections known as cilia. But cilia are also found in human cells, helping move fluid and mucous around in the brain, lung, eye and kidney, or sticking out from cells to act like antennae.

Studying families with a relatively rare condition called Bardet-Biedl syndrome (BBS), characterized by obesity, learning disabilities and eye and kidney problems, the researchers discovered a new gene involved. Furthermore, the gene's protein, BBS8, is found only at the base of cilia, the scientists report in the Sept. 21 advance online section of Nature.

"BBS is a relatively rare genetic disorder, but it has traits common to many people," says Nicholas Katsanis, Ph.D., assistant professor in the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins. "We don't know yet how the ciliary defect might lead to obesity or learning disabilities, but the finding provides a new avenue to studying these genetically murky traits.

"It is very difficult to translate genetic understanding into a cellular mechanism that explains what is seen in a disease. But such efforts are what genetic medicine is all about," adds Katsanis.

Some aspects of BBS have been linked to ciliary defects in other conditions. Cilia are known to play key roles in mammalian development, creating what's known as left-right asymmetry so organs like the heart, lungs and liver end up in the right place. In people with BBS, sometimes left-right asymmetry is reversed. Also, malfunctioning cilia in the back of the eye are known to cause retinal dystrophy and eventual blindness, and ciliary problems in the kidney lead to structural problems in the organ.

But even though these primary characteristics of BBS had been tied to ciliary defects, the condition itself and its other traits -- obesity, learning disa
'"/>


21-Sep-2003


Page: 1 2 3

Related biology news :

1. Cellular problems found behind complex obesity syndrome
2. Cellular fat sensor slows heart disease
3. Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize
4. Cellular pathway includes a clock that steers gene activity
5. Cellular organelle evolved repeatedly
6. Cellular membrane changes associated with acclimation to cold
7. Cellular espionage at play in post-menopausal osteoporosis
8. Dual Control Strategy Assures Accurate Cellular Marching Orders, But A Pathogenic Microbe Can Hijack The System
9. UC Davis Researchers Get First Look At A Working Cellular Motor
10. Cellular Target Of Leprosy, Deadly Viruses Found
11. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a registered ... common and aggressive adult brain cancer—announced today the appointments of its first Senior ... with supporting the organization’s initiatives and overall vision. , "Senior Fellows are more ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... development services, today announced that the company has received ISO9001:2015 certification for ... diagnostics, and research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... In its ... feature interview with Dr. James L. Sherley, M.D., Ph.D., founder and director of ... the company announced on June 16 that starting July 5 it would ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... ... today announced that it has filed an Investigational New Drug application (IND) with ... trial of its lead drug candidate NBTX-001 in patients with panic disorder (PD). ...
(Date:6/11/2020)... ... June 09, 2020 , ... TRX Systems, developer ... Micro-Tracer Solution, a highly accurate, contact tracing solution for identification of employees ... tracing, a core disease control measure, is a key strategy for preventing further ...
(Date:5/30/2020)... (PRWEB) , ... May 29, 2020 , ... ... biotech, medical device, diagnostics, and animal health markets, has enabled Cytovale, Inc., a ... cell mechanics and machine learning, to achieve their first patient in (FPI) in ...
(Date:5/26/2020)... ... 2020 , ... Brilliant , the leading smart home control and lighting ... announce a new integration to bring more convenience, simplicity, and security to the smart ... Connect® can now be controlled from Brilliant’s in-wall touchscreen control panels and mobile app. ...
Breaking Biology Technology:
Cached News: