Cellular problems found behind complex obesity syndrome

besity may be common in people with the disorder, including improperly controlled or targeted neurons, improper hormone release, and improper growth of fat cells, all of which may short-circuit normal appetite controls. However, experiments with genetically engineered mice will be necessary to know for sure, he says.

Although the work is far from revealing an anti-obesity "magic bullet," the researchers, also from Simon Fraser University in Canada and the University College London, say it does point to microtubule failure as a primary mechanism for the problems seen in BBS, particularly the disorder's obesity, diabetes and retinal degeneration. Moreover, their discovery adds to evidence that the cells' highway system could be a major factor in other multisystem disorders.

"It's becoming very clear that microtubules are so fundamental to cells that if you hit the system with a genetic mutation you will get a disease," says Katsanis. "It's likely that some genes implicated in other multisystem disorders may compromise microtubules' functions, especially in diseases whose physical characteristics overlap with those of BBS."

Microtubules act as the roads that chromosomes travel in order to move to opposite sides of the cell during cell division. They also transport molecules and packets of molecules to the cell membrane for release from the cell, and are the primary skeleton in cellular structures called cilia. BBS4 mutations are likely to affect different microtubule functions in different cell types, including the transport of proteins up and down cilia, Katsanis says.

"In our in vitro systems, if BBS4 didn't work, all the cells died because of microtubule failure," says Katsanis. "It's very likely that in engineered mice, we also may see slower growth, less cell division, and other mutation-induced changes that will explain the condition's various effects. Cell death won't be the only problem."


Contact: Joanna Downer
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. Cellular fat sensor slows heart disease
2. Cellular problem discovered behind syndrome of obesity, learning disabilities
3. Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize
4. Cellular pathway includes a clock that steers gene activity
5. Cellular organelle evolved repeatedly
6. Cellular membrane changes associated with acclimation to cold
7. Cellular espionage at play in post-menopausal osteoporosis
8. Dual Control Strategy Assures Accurate Cellular Marching Orders, But A Pathogenic Microbe Can Hijack The System
9. UC Davis Researchers Get First Look At A Working Cellular Motor
10. Cellular Target Of Leprosy, Deadly Viruses Found
11. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies

Post Your Comments:

(Date:8/14/2019)... ... 14, 2019 , ... Representatives with MyBioGate announced that China Focus@Biotech Week will ... “We help innovative projects connect with Chinese pharma and investors in healthcare innovation,” said ... to explain that as a part of Biotech Week Boston – the annual biotech ...
(Date:8/14/2019)... ... August 13, 2019 , ... Join Anguraj Sadanandam, ... Institute of Cancer Research (ICR) in a live webinar on Wednesday, ... of biomarker and companion diagnostic development including machine learning approaches in different gastrointestinal ...
(Date:8/9/2019)... ... August 09, 2019 , ... With a demand in ... and more patients will visit urgent care centers (UCC) in the coming years, according ... report, The Market for Urgent Care Centers , is a detailed look at ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC bio, ... an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector for ... dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related retinal ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check your local listings ... and will educate viewers about how its technology facilitates laboratories to improve efficiency ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
(Date:5/31/2019)... (PRWEB) , ... May 30, 2019 , ... ... regulatory thinking on Data Integrity on July 08-09, 2019 in Boston, MA. This ... biotech and medical device organizations. , The training will kick off with a ...
Breaking Biology Technology:
Cached News: