HOME >> BIOLOGY >> NEWS
Change In HIV May Precipitate AIDS

Scientists at the National Institute of Child Health and Human Development (NICHD) have developed a new model for studying the destructive effects of AIDS in live tissue samples. The critical events in the development of AIDS take place in lymphoid tissue, but AIDS research has been hampered by the fact that an animal model of HIV infection that readily mimics human AIDS does not exist. Scientists also lack readily available laboratory techniques for closely mimicking, in vitro, HIV infection in the body (in vivo).

The NICHD scientists have overcome this limitation by culturing and infecting pieces of tonsil, which is composed largely of lymphoid tissue, obtained from tonsillectomies. With this advance, they have helped illuminate one of the central questions of HIV pathology--what triggers the eventual development of AIDS in people who carry HIV?

The finding appears in the March issue of Nature Medicine, and was reported by scientists Svetlana Glushakova, Jean-Charles Grivel, Wendy Fitzgerald, Andrew Sylvester, Joshua Zimmerberg, and Leonid Margolis.

The laboratory model, which allows HIV to be studied in the tissue in which it is usually found, consists of tiny (1mm) cubes of tonsil cultured on wet collagen sponges. The cubes, which retain their viability and native architecture for several weeks, can be infected with HIV (which multiplies and spills into the surrounding medium), so that they mount a response to immunological challenge. Such responses are the hallmark of lymphoid tissue. Thus, just as they would in the body, the blocks of lymphoid tissue make antibodies to tetanus toxoid or diphtheria toxoid (which are used to immunize people against tetanus and diphtheria), and they do so with much greater efficiency than isolated immune cells, underscoring the importance of the cell's environment to the cell's proper functioning.

With the help of these cultured, immunologically responsive, tonsil
'"/>

Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
12-Mar-1998


Page: 1 2

Related biology news :

1. Changes to insect-seeking calls of horseshoe bats may drive new species formation
2. Changes in shape of single protein plays key role in the spread of cancer cells
3. Changes in arctic ice affect life around the globe
4. Changes in jet stream, storm tracks, linked to prairie drought patterns, study finds
5. Changes in prevalence of mutations associated with HIV treatment failure
6. Evolution: Driving Change
7. Changes in rainfall patterns spur plant growth, carbon absorption across U.S.
8. Changes in agricultural practices help clean up Lake Erie
9. Changes in Lake Erie fish population suggest lakes recovery
10. Talk: Population and Climate Change: Neglected Connections
11. Changes in Australian ecosystems tied to arrival of exotic animals

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Change HIV May Precipitate AIDS

(Date:7/28/2014)... TEMPE, Ariz. - Reactions among minerals and organic compounds ... deep carbon cycle, they provide energy for the deep ... life. However, very little is known about how minerals ... Arizona State University have demonstrated how a common mineral ... negating the need for toxic solvents or expensive ...
(Date:7/28/2014)... Solanum pennellii , a wild relative of the domestic ... researchers including the labs headed by Professors Neelima Sinha ... Plant Biology. The new genome information may help breeders ... July 27 in the journal Nature Genetics , ... University in Germany. The UC Davis labs carried out ...
(Date:7/28/2014)... research has identified areas of the Earth that are ... change. , Europe is particularly vulnerable, as it has ... per cent, of any continent in ,refugia, areas ... environmental conditions remain relatively constant during times of great ... are mostly in Scandinavia and Scotland. , The ...
Breaking Biology News(10 mins):Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
(Date:7/29/2014)... (PRWEB) July 29, 2014 The first ... a next generation approach to robotics. What sets Droidles ... patent pending technology that allows them to communicate, share ... wirelessly over the internet. , β€œThe invention is the ... the little Droidles a life of their own, both ...
(Date:7/29/2014)... Acres, FL (PRWEB) July 29, 2014 ... ex situ lift out specimen preparation solutions, has been ... Trademark Office for specimen manipulation methods incorporating a unique ... 8,740,209. This is the second company patent for ... A. Giannuzzi. , These complementary patents extend ...
(Date:7/28/2014)... July 28, 2014 β€œ2014 ... Lubricant Industry” is a professional and in-depth ... market. The report introduces Lubricant basic information, ... chain structure and industry overview. This research ... domestic market as well as global industry ...
(Date:7/28/2014)... 28, 2014 According ... Market by Products (Consumables, Instruments, Services), Methods (Phenotypic, Genotypic), Applications (Pharmaceutical, ... (Detection, Characterization) - Global Forecasts to 2019" ... is estimated at $896.5 Million in 2014 ... by 2019, growing at a CAGR of ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3
Cached News: