HOME >> BIOLOGY >> NEWS
Change In HIV May Precipitate AIDS

Scientists at the National Institute of Child Health and Human Development (NICHD) have developed a new model for studying the destructive effects of AIDS in live tissue samples. The critical events in the development of AIDS take place in lymphoid tissue, but AIDS research has been hampered by the fact that an animal model of HIV infection that readily mimics human AIDS does not exist. Scientists also lack readily available laboratory techniques for closely mimicking, in vitro, HIV infection in the body (in vivo).

The NICHD scientists have overcome this limitation by culturing and infecting pieces of tonsil, which is composed largely of lymphoid tissue, obtained from tonsillectomies. With this advance, they have helped illuminate one of the central questions of HIV pathology--what triggers the eventual development of AIDS in people who carry HIV?

The finding appears in the March issue of Nature Medicine, and was reported by scientists Svetlana Glushakova, Jean-Charles Grivel, Wendy Fitzgerald, Andrew Sylvester, Joshua Zimmerberg, and Leonid Margolis.

The laboratory model, which allows HIV to be studied in the tissue in which it is usually found, consists of tiny (1mm) cubes of tonsil cultured on wet collagen sponges. The cubes, which retain their viability and native architecture for several weeks, can be infected with HIV (which multiplies and spills into the surrounding medium), so that they mount a response to immunological challenge. Such responses are the hallmark of lymphoid tissue. Thus, just as they would in the body, the blocks of lymphoid tissue make antibodies to tetanus toxoid or diphtheria toxoid (which are used to immunize people against tetanus and diphtheria), and they do so with much greater efficiency than isolated immune cells, underscoring the importance of the cell's environment to the cell's proper functioning.

With the help of these cultured, immunologically responsive, tonsil
'"/>

Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
12-Mar-1998


Page: 1 2

Related biology news :

1. Changes to insect-seeking calls of horseshoe bats may drive new species formation
2. Changes in shape of single protein plays key role in the spread of cancer cells
3. Changes in arctic ice affect life around the globe
4. Changes in jet stream, storm tracks, linked to prairie drought patterns, study finds
5. Changes in prevalence of mutations associated with HIV treatment failure
6. Evolution: Driving Change
7. Changes in rainfall patterns spur plant growth, carbon absorption across U.S.
8. Changes in agricultural practices help clean up Lake Erie
9. Changes in Lake Erie fish population suggest lakes recovery
10. Talk: Population and Climate Change: Neglected Connections
11. Changes in Australian ecosystems tied to arrival of exotic animals

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Change HIV May Precipitate AIDS

(Date:6/24/2015)... YORK , June 24, 2015 The ... rate. The major drivers for the market include growth ... number of new drug launches. Over the years, the ... increased. Between 2001 and 2010, the FDA approved 225 ... according to WIPO, Europe accounted ...
(Date:6/24/2015)... 2015 Biometry authentication provider KeyLemon today ... solution one face in. Logo ... face in, entering the expanding biometric authentication market ... biometric answer to the password problem. With advanced ... with KeyLemon, one face in allows users to ...
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
Breaking Biology News(10 mins):Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
(Date:7/1/2015)... July 1, 2015  Axovant Sciences Ltd. (NYSE: ... the treatment of dementia, today announced that the ... 22 at 5:45 p.m. EDT following its presentation ... International Conference 2015 (AAIC). The ... , Dr. Lawrence Friedhoff , Chief Development ...
(Date:7/1/2015)... ... 01, 2015 , ... A newly launched business plan contest will ask startup ... innovation in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 will see ... a period of expert mentorship from a senior industry figure drawn from the Pistoia ...
(Date:7/1/2015)... ... 01, 2015 , ... Apex Therapeutics announced today that company CEO, David Broecker ... , The presentation took place on Tuesday, June 16 and provided an update ... APX3330 for the treatment of pancreatic cancer. A copy of the company overview ...
(Date:7/1/2015)... July 1, 2015  UCB, a multinational biopharmaceutical ... global leader in designing, transforming, and running intelligent ... in recognition of their close collaboration in driving ... global business services (GBS) finance organization. ... clients that work together effectively to embrace the ...
Breaking Biology Technology:Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
Cached News: