HOME >> BIOLOGY >> NEWS
Change In HIV May Precipitate AIDS

Scientists at the National Institute of Child Health and Human Development (NICHD) have developed a new model for studying the destructive effects of AIDS in live tissue samples. The critical events in the development of AIDS take place in lymphoid tissue, but AIDS research has been hampered by the fact that an animal model of HIV infection that readily mimics human AIDS does not exist. Scientists also lack readily available laboratory techniques for closely mimicking, in vitro, HIV infection in the body (in vivo).

The NICHD scientists have overcome this limitation by culturing and infecting pieces of tonsil, which is composed largely of lymphoid tissue, obtained from tonsillectomies. With this advance, they have helped illuminate one of the central questions of HIV pathology--what triggers the eventual development of AIDS in people who carry HIV?

The finding appears in the March issue of Nature Medicine, and was reported by scientists Svetlana Glushakova, Jean-Charles Grivel, Wendy Fitzgerald, Andrew Sylvester, Joshua Zimmerberg, and Leonid Margolis.

The laboratory model, which allows HIV to be studied in the tissue in which it is usually found, consists of tiny (1mm) cubes of tonsil cultured on wet collagen sponges. The cubes, which retain their viability and native architecture for several weeks, can be infected with HIV (which multiplies and spills into the surrounding medium), so that they mount a response to immunological challenge. Such responses are the hallmark of lymphoid tissue. Thus, just as they would in the body, the blocks of lymphoid tissue make antibodies to tetanus toxoid or diphtheria toxoid (which are used to immunize people against tetanus and diphtheria), and they do so with much greater efficiency than isolated immune cells, underscoring the importance of the cell's environment to the cell's proper functioning.

With the help of these cultured, immunologically responsive, tonsil
'"/>

Contact: Bob Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
12-Mar-1998


Page: 1 2

Related biology news :

1. Changes to insect-seeking calls of horseshoe bats may drive new species formation
2. Changes in shape of single protein plays key role in the spread of cancer cells
3. Changes in arctic ice affect life around the globe
4. Changes in jet stream, storm tracks, linked to prairie drought patterns, study finds
5. Changes in prevalence of mutations associated with HIV treatment failure
6. Evolution: Driving Change
7. Changes in rainfall patterns spur plant growth, carbon absorption across U.S.
8. Changes in agricultural practices help clean up Lake Erie
9. Changes in Lake Erie fish population suggest lakes recovery
10. Talk: Population and Climate Change: Neglected Connections
11. Changes in Australian ecosystems tied to arrival of exotic animals

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Change HIV May Precipitate AIDS

(Date:12/17/2014)... and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has announced ... Home Button Synaptics Fingerprint Sensor Technology Analysis" report ... Based on a totally different sensing ... first time a fingerprint sensor in its product. ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM announced today ... to confirm its adherence to current U.S. Food and ... conduct regulated smart device and smart phone application trials ... quality. "HITLAB is determined to improve global ...
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Sensor Market 2015-2019" report to their offering. ... major trend upcoming in this market is the increasing ... help in recording of patient data for quick and ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
(Date:1/22/2015)... laboratory information management systems market is a rapidly growing ... due to factors such as rising pressure to comply ... and increasing government support for adoption of HCIT solutions ... the market focus on technological advancements to further the ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was invited ... seminar on probiotics in San Diego, CA. , The ... for health care professionals. This year’s pre-conference seminar was held ... health. Dr. Leyer spoke about the emerging topics and science ...
(Date:1/22/2015)... 22, 2015   Cypher Genomics, Inc., the ... SQNM ), the leading molecular diagnostics ... generation noninvasive prenatal tests (NIPT). Through this agreement, ... Mantis™, to advance analysis of clinically-relevant fetal sub-chromosomal ...
(Date:12/24/2014)... Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market approval application ... the use of Medtronic,s SynchroMed ® II implantable ... use with United Therapeutics, Remodulin ® (treprostinil) Injection ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
Cached News: