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Changes in prevalence of mutations associated with HIV treatment failure

Boston (Feb. 13, 2003) — The results from a longitudinal study of the relative frequency of various types of HIV mutations associated with the use of antiretroviral therapy (ART) were presented today at a meeting of leading AIDS researchers. The study showed that the prevalence of most key mutations associated with antiretroviral resistance have changed significantly from 1999-2002.

Specifically, the results showed that the prevalence of thymidine analog mutations (TAMs) and other key mutations associated with HIV drug resistance has decreased significantly as reported in the LabCorp Database in recent years, while mutations such as K65R and Y115F are on the rise.

"Although further studies are needed to determine the reasons behind these findings, the increased use of three drug regimens, the introduction of new drugs and/or drug combinations and changes in the submission of patient samples for genotyping may all be factors affecting the changing patterns of HIV mutations in this large sample," said Doug Manion, M.D., vice president of Clinical Development, GSK.

The results come from a longitudinal study of the relative frequency of all primary mutations and many combinations of mutations associated with ART from January 1, 1999, through July 1, 2002. The study involved nearly 38,000 genotypic tests performed between 1999 and mid-2002 to identify mutations associated with HIV resistance to antiretroviral drugs, including nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs).

Trends in the use of specific antiretroviral therapies in the United States during the same time period also were presented by the researchers.

Study investigators noted that the databases used are not linked, and the results show independent trends, not a direct correlation between drug usage and mutation incidence. However, the data show that the changes in presc
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Contact: Amy Kling
akling@pcipr.com
Public Communications Inc.
13-Feb-2003


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