HOME >> BIOLOGY >> NEWS
Checking how cells grow

Research published today in Journal of Biology challenges an assumption about cell growth that underpins modern cellular biology. Ian Conlon and Martin Raff, of University College London, show that mammalian cells do not regulate their size in the way scientists have assumed they do since the 1970s.

Conlon and Raff conducted a series of experiments, using Schwann cells from the sciatic nerve of rats, to establish how mammalian cells control their size and 'decide' when to divide. This processes of cell size, growth and division has been widely studied in yeast for thirty years, and many aspects are the same in the two types of cell. Both yeast and mammalian cells are known to be able to maintain a constant average size as they grow and divide. It has therefore been assumed that the 'checkpoints' yeast cells use to ensure that they divide when they reach the correct size are mirrored by checkpoints in mammalian cells, but that assumption had not been tested experimentally - until now.

Using precise measurements, Conlon and Raff found key differences in the ways yeast and mammalian cells grow. Yeast cells grow exponentially, doubling in size over a fixed time period, but mammalian cells grow in a linear way, getting larger by the same amount each day; this means that the rate at which mammalian cells grow is the same regardless of the cell's size, whereas in yeast big cells grow faster than small ones.

Previous research had shown that when moved to a nutrient-rich environment, yeast cells adjust quickly - within one cycle of growth and division. The average size of the cells increases when there are more nutrients available so, yeast uses cell-size checkpoints to determine how large the cell should be before it divides.

It had been assumed that mammalian cells also use cell-size checkpoints. But Conlon and Raff found that when mammalian cells were moved to a nutrient-rich environme
'"/>

Contact: Grace Baynes
press@biomedcentral.com
44-20-7323-2988
BioMed Central
24-Apr-2003


Page: 1 2

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Researchers develop fast track way to discover how cells are regulated
3. Chemical signals health of brain cells Symposium
4. New dye directly reveals activated proteins in living cells
5. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
6. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
7. Smac-ing back at cancer cells
8. Bone marrow cells routinely help with wound healing
9. Genuine stem cells found in skin might treat hair loss, wounds
10. Skin stem cells give hairless mice hair
11. Small, Smac-like molecule encourages death of cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... WORCESTER, Mass. (PRWEB) , ... May 21, 2019 ... ... released into the environment, how will we know? How can we tell it ... the challenge being taken on by a multi-institution research team, including Eric ...
(Date:5/21/2019)... ... 21, 2019 , ... Zer0 to 5ive, an award-winning strategic ... celebrate launched a new startup package, 0to5 Launch, to provide seed-stage and early-stage ... to attract talent and investors. , “We launched our Zer0 to 5ive Roadmap™ ...
(Date:5/21/2019)... , ... May 20, 2019 , ... ... health care field, today announced a 96.15% pass rate for first-time test takers ... This surpasses the national average of 76.43% by nearly 20 points. , ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ANTONIO (PRWEB) , ... April 16, 2019 , ... ... human identification systems, applications, and technology, today announced that Bank South Pacific (BSP), ... a competitive RFP process. The bank awarded Fulcrum a contract to deliver a ...
(Date:4/9/2019)... SANTA BARBARA, Calif. (PRWEB) , ... April 09, ... ... global professional services firm focused on increasing the capacity of life sciences organizations ... to its Cloud Assurance platform in the past 12 months. , ...
(Date:4/8/2019)... ... April 09, 2019 , ... ... innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics ... repertoires is part of CZ Biohub’s efforts to establish new approaches to inform ...
(Date:3/27/2019)... (PRWEB) , ... March 27, 2019 , ... In honor ... raise awareness on the importance of healthy meals and good nutrition. This month, ... the Food Bank’s volunteer chef. , The first segment addressed the nutritional ...
Breaking Biology Technology:
Cached News: