HOME >> BIOLOGY >> NEWS
Chemical derived from vitamin-E shows early promise as cancer drug

AUSTIN, Texas By studying cancer in mice, researchers at The University of Texas at Austin have gained preliminary evidence that a novel compound that resembles vitamin E halves the size of tumors and the ability of cancer to spread to other body sites.

"We have clear evidence that this chemical is directly causing cancer cells to die," said Kimberly Kline, a nutrition professor in the Department of Human Ecology who directed the research in collaboration with Bob G. Sanders, a professor in the School of Biological Sciences.

The findings will be published in the October issue of Experimental Biology and Medicine. They result from studies involving treatment of genetically identical mice, which were given the novel vitamin E compound either orally or by aerosol.

Based on earlier, similar findings by Kline and colleagues, the National Cancer Institute is funding national efforts to investigate the ability of this novel compound, RRR-alpha-tocopherol ether acetic analog (alpha-TEA), to prevent colon and breast cancers in preclinical animal models.

Mice in the study were treated with alpha-TEA for 21 days after an injection of mouse-derived mammary cancer cells that normally would have formed a tumor mass and spread (metastasized) to the animals' lungs. Regardless of whether alpha-TEA was administered to the mice by mouth (orally) or via breathing (aerosol), the compound was capable of reducing the primary tumor mass by greater than half.

In addition, the compound was capable of reducing tumor lesions (metastases) in the lung that were big enough to see with the naked eye. For example, only one of 10 alpha-TEA aerosol-treated mice developed visible lung tumor lesions in comparison to five of 10 untreated control mice. None of the treated animals showed any type of general symptoms of toxicity to alpha-TEA, which Kline chose for further study in 1997 from 50 candidates.

Because cancer may result from
'"/>

Contact: Barbra Rodriguez
brodriguez@mail.utexas.edu
512-232-0675
University of Texas at Austin
30-Sep-2004


Page: 1 2 3

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. Chemical genetics identifies SARS inhibitors
3. Chemical signals health of brain cells Symposium
4. Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
5. Chemical engineers discover filtration system to help biotech industry
6. NIH roadmap for biomedical research focus of chemists at American Chemical Society meeting
7. American Chemical Society media registration
8. Chemical Society announces EPA awards for environmentally friendly technology
9. NIH launches first center in Nationwide Chemical Genomics Network
10. Chemical reaction in birds provides sense of direction during migratory flights
11. Annual Chemical Biology Symposium at Yale May 14, 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/27/2019)... ... April 26, 2019 , ... ... Assessment Report: The Laboratory Analytical & Life Science Instrumentation Industry ," provides ... that include chromatography, life science instrumentation, mass spectrometry, molecular spectroscopy, atomic spectroscopy, ...
(Date:4/25/2019)... ... , ... NDA Partners Chairman Carl Peck, MD , announced today that ... development of drug and genomic diagnostic products for therapeutic indications in oncology, has joined ... Maddala served as Vice President of Biometrics at GRAIL, Inc., where she built and ...
(Date:4/18/2019)... GUILFORD, Conn. and WALNUT CREEK, Calif. (PRWEB) , ... ... ... services cost management solution for the healthcare industry, today announced the launch of ... natural language processing to extract deep knowledge of Medpricer customers’ supplier contracts, truly ...
Breaking Biology News(10 mins):
(Date:5/7/2019)... ... May 06, 2019 , ... "The new ... number of repositories being asked to store cellular products being used in ... contributors who are world leaders, who have shared their expertise in building and ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, ... Diopsys® ffERG/Photopic Negative Response vision test, a new full field electroretinography (ffERG) ... estimated that 6.3 million Americans will have glaucoma, with black Americans having the ...
(Date:5/2/2019)... ... April 30, 2019 , ... The centuries old practice of ... breweries to local craft breweries, and even home brewing clubs scattered across the nation. ... biological processes, that when mastered can produce a superb product. Students at South ...
(Date:5/2/2019)... ... May 02, 2019 , ... Researchers ... present results documenting discrepancies between U.S. insurer policies for genetic testing and the ... for hereditary breast and ovarian cancer (HBOC). , Jill S. Dolinsky, ...
Breaking Biology Technology:
Cached News: