HOME >> BIOLOGY >> NEWS
Chemical from venom of Chilean tarantula could aid treatment of heart attack, other major diseases

BUFFALO, N.Y. -- University at Buffalo biophysicists have identified a component of venom from a very large, very hairy Chilean tarantula that blocks the action of ion channels that are responsible for cellular mechanical responses -- the cell's ability to feel.

These channels or pores in the cell membrane -- called stretch-activated channels because stretching the membrane causes them to open and close -- have been implicated in functions as diverse as the senses of touch and hearing, muscle contraction and coordination, and blood pressure and volume regulation.

This is the first report of a substance -- in this case a small protein -- that specifically blocks stretch-activated channels. Until now, it has been difficult to associate these channels with particular functions because there were no chemical compounds known specifically to block them.

Results of the research appear in the current issue of the Journal of General Physiology. Scientists from the University of Virginia, Michigan State University and NPS Pharmaceuticals collaborated with UB researchers on the study.

The newly identified peptide toxin could have several clinical applications related to cell mechanics, said Frederick Sachs, Ph.D., UB professor of physiology and biophysics, and senior researcher on the project.

"For example, cells swell during congestive heart failure. The peptide interferes with that process. We also know from earlier work that stretching the heart can initiate fibrillation. If we can block the stretch-activated channels, we may be able to block fibrillation, a major cause of death following heart attacks."

Addressing another area, Sachs said tumor invasion of brain tissue produces a deformation of the surrounding normal cells, causing them to release growth factors that may facilitate or accelerate tumor growth. Stretch-activated channels may be the signal for normal cells to release growth factors.

"This peptide blocks those cha
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000, x 1417
University at Buffalo
15-May-2000


Page: 1 2 3

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. Chemical derived from vitamin-E shows early promise as cancer drug
3. Chemical genetics identifies SARS inhibitors
4. Chemical signals health of brain cells Symposium
5. Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
6. Chemical engineers discover filtration system to help biotech industry
7. NIH roadmap for biomedical research focus of chemists at American Chemical Society meeting
8. American Chemical Society media registration
9. Chemical Society announces EPA awards for environmentally friendly technology
10. NIH launches first center in Nationwide Chemical Genomics Network
11. Chemical reaction in birds provides sense of direction during migratory flights

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... August 29, 2019 , ... Advancements ... robotics platform in an upcoming episode, which is scheduled to broadcast 1Q/2020. Check ... and commercialization of cost-effective robotic surgical solutions for the treatment of patients suffering ...
(Date:8/27/2019)... (PRWEB) , ... August 26, 2019 , ... Shoreline ... to the strain level, has hired Bill McKenzie as its CEO and Karen Woodward ... to help Shoreline Biome meet growing demand for its products and expand the company’s ...
(Date:8/27/2019)... , ... August 27, 2019 , ... ... science and drug development. This episode is scheduled to broadcast 4Q/2019. Check local ... a biopharmaceutical research, development, investment and manufacturing company. The show will highlight how ...
Breaking Biology News(10 mins):
(Date:8/27/2019)... (PRWEB) , ... August 27, 2019 , ... Dr. Kim ... She recently opened North Peninsula Veterinary Surgical Group , a new surgical practice ... there are plans to expand and add more veterinary specialists as the practice grows. ...
(Date:8/23/2019)... ... August 22, 2019 , ... The EnozoPro® converts ordinary tap water into ... and pathogens on hard surfaces including E. Coli, Salmonella, MRSA, Listeria and Legionella. It ... more information, visit the product page at rovingblue.com , ”At Enozo, our mission is ...
(Date:8/14/2019)... COLLEGE, Pa. (PRWEB) , ... August 13, 2019 ... ... in nuclear receptor and in vitro toxicology testing solutions, announced the appointment of ... healthcare industry experience to the Board. , Mark McLoughlin will lend his healthcare ...
(Date:8/7/2019)... SOLON, Ohio (PRWEB) , ... August 07, 2019 , ... ... with a breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , ... within a year—the largest impact any approach has offered to date. Results from the ...
Breaking Biology Technology:
Cached News: