HOME >> BIOLOGY >> NEWS
Chemicals used to protect soldiers in 1991 Gulf War can damage testes, animal studies show

DURHAM, N.C. -- A combination of chemicals given to protect Gulf War soldiers against deadly diseases and nerve gas may have inadvertently damaged their testes and sperm production, according to animal experiments at Duke University Medical Center.

The new study could explain why some veterans have experienced infertility, sexual dysfunction, and other genitourinary symptoms, said Mohamed Abou Donia, Ph.D., a Duke pharmacologist.

Three chemicals were given to soldiers to protect them against insect-borne diseases and nerve-gas poisoning: the insect repellent DEET, the insecticide permethrin, and the anti-nerve gas agent pyridostigmine bromide.

In a study designed to mimic those same conditions, Abou Donia and his colleagues gave rats equivalent doses to what the soldiers received. When given together, the chemicals caused extensive cell degeneration and cell death with various structures of the testes, he found. The damage was even more severe among rats that were exposed to moderately stressful situations in addition to the chemicals.

Results of the study, funded by the Department of Defense, are published in the Jan. 10, 2003 issue of The Journal ofToxicology and Environmental Health.

"It appears that moderate stress, combined with the three chemicals, caused the most severe deterioration in testicular structure and sperm production, and these conditions were likely experienced by some Gulf War soldiers in the combat environment," said Abou Donia, principal investigator of the study.

"Interestingly, the chemically-treated rats don't look or behave any differently than normal rats, just as the soldiers don't show any outward signs of disease," said Abou Donia. "But under a microscope, you can see clear and well-defined damage to a variety of testicular structures."

Abou Donia's team found the most pervasive cell damage within basal germ cells and spermatocytes, which give rise to mature sperm. The three che
'"/>

Contact: Rebecca Levine
levin005@mc.duke.edu
919-684-4148
Duke University Medical Center
8-Jan-2003


Page: 1 2 3

Related biology news :

1. Chemicals in frying pan a potential hazard to environment
2. Chemicals in carpet can linger long after exposure
3. Fine Toothed Combs, Not Chemicals, Should Be Used To Treat Head Lice
4. Successful Green Solvent Found For Problematic Chemicals
5. New Study Highlights Hazards On Hormone Disrupting Chemicals
6. 15 Drugs, Dyes And Other Chemicals Newly Listed As Known Or Likely Human Carcinogens
7. Banning Chemicals To Protect Ozone May Aggravate Global Warming
8. Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules
9. Certain genes boost fish oils protection against breast cancer
10. DuPont introduces in-home personal protection from dangers of hurricanes
11. New way to protect brain from stroke damage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... ... In its June 22 online post, business and technology news platform Superb Crew ... and director of stem cell biotechnology company Asymmetrex . Superb Crew decided to ... 5 it would begin offering free tissue stem cell counting at its ...
(Date:6/19/2020)... ... June 18, 2020 , ... Join experts from Envigo Lauren Klaskala, ... live webinar on Wednesday, July 8, 2020 at 11am EDT (4pm BST/UK). ... engineer new models. However, while modifying the genome may be more straightforward, the challenge ...
(Date:6/11/2020)... (PRWEB) , ... June 09, 2020 , ... Superior ... custom industrial automation and IT solutions for the life sciences industry, is pleased to ... Business Development working out of the company’s Seabrook, New Hampshire office. In his ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... , ... July 29, 2020 , ... ... solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, ... that can drive one or two switches in a push-pull configuration; yielding fast ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... today announced the release of its signature product called Beacon - a ... and other field medical professionals. , Beacon helps MSLs streamline communication ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a leading ... food industries, is pleased to announce that Charles Galea has joined its clinical ... Charles is an accomplished and results-driven sales executive with over 10 years of ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering stem cell therapy ... stem cells. Depending on the patient's condition, treatment may be offered IV, intrathecal or ... some form of Alzheimers dementia, and the incidence continues to increase as individuals live ...
Breaking Biology Technology:
Cached News: