Chemists characterize regulators of zinc intake and export in cells

ich provides a good model of zinc metabolism in animal cells. They found that when the amount of zinc in the cell increases to a point where zinc is no longer needed for cellular tasks, the extra zinc binds tightly to the protein Zur. This reaction in turn shuts down the zinc intake pump.

In the case of the regulatory protein ZntR, the opposite happens when it combines with zinc. When ZntR senses any extra zinc after the intake pump has been shut off, ZntR binds with the zinc, turning on the export pump. Any unwanted and potentially dangerous zinc is pumped out of the cell.

The researchers determined the concentrations of zinc required within the cell in order for the proteins to turn off and on the pumps. They showed that the regulatory system is so sensitive and finely tuned that zinc does not have the opportunity to float freely in the cells cytoplasm before it binds to either Zur or ZntR, depending on the cycle.

"The zinc concentration is so low in between pump activity that free-floating zinc just doesnt exist," said Outten, now a post-doctoral researcher at Johns Hopkins Bloomberg School of Public Health. "Its a kinetic process any zinc that shows up in the cell is immediately taken away, to work reactions in the cell, to bind to proteins such as Zur or ZntR or, if no zinc is needed, to be sent packing out of the cell."


Contact: Megan Fellman
Northwestern University

Page: 1 2

Related biology news :

1. Chemists at four pharmaceutical companies named Heroes for treating childhood conditions
2. Chemists unlock secret to activating tumor suppressor gene
3. Chemists create unusual lariat RNA, a key intermediate in biological splicing
4. American Institute of Chemists names Ralph Hirschmann AIC Gold Medalist
5. Chemists explore the shape of the key that signals cell division in cancer cells
6. Nanoencapsulation: Chemists at TSRI discover a new and simple way of controlling reactions
7. Chemists spin materials to improve magnetic resonance data
8. Chemists describe "zipper teeth" of DNA molecules -- publish results in the journal Nature
9. Chemists report new approach to synthetic fragments of medically important Heparin
10. Chemists hold national meeting August 22-26
11. Chemists hold national meeting August 22-26 in New Orleans

Post Your Comments:

(Date:6/2/2016)... , June 2, 2016   The Weather Company ... announcing Watson Ads, an industry-first capability in which consumers will ... being able to ask questions via voice or text and ... Marketers have long sought an ... consumer, that can be personal, relevant and valuable; and can ...
(Date:6/1/2016)... Favorable Government Initiatives Coupled With ... Identification to Boost Global Biometrics System Market Through 2021  ... report, " Global Biometrics Market By Type, By ... 2011 - 2021", the global biometrics market is projected ... of growing security concerns across various end use sectors ...
(Date:5/20/2016)... 20, 2016  VoiceIt is excited to announce ... By working together, VoiceIt and VoicePass ... and VoicePass take slightly different approaches to voice ... security and usability. ... new partnership. "This marketing and technology ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, ... microbial test has received AOAC Research Institute approval 061601. , “This is another ... year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel ...
(Date:6/23/2016)... ... ... Supplyframe, the Industry Network for electronics hardware design and ... in Pasadena, Calif., the Design Lab’s mission is to bring together inventors and ... brought to market. , The Design Lab is Supplyframe’s physical representation of one ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
Breaking Biology Technology:
Cached News: