HOME >> BIOLOGY >> NEWS
Chemists characterize regulators of zinc intake and export in cells

ich provides a good model of zinc metabolism in animal cells. They found that when the amount of zinc in the cell increases to a point where zinc is no longer needed for cellular tasks, the extra zinc binds tightly to the protein Zur. This reaction in turn shuts down the zinc intake pump.

In the case of the regulatory protein ZntR, the opposite happens when it combines with zinc. When ZntR senses any extra zinc after the intake pump has been shut off, ZntR binds with the zinc, turning on the export pump. Any unwanted and potentially dangerous zinc is pumped out of the cell.

The researchers determined the concentrations of zinc required within the cell in order for the proteins to turn off and on the pumps. They showed that the regulatory system is so sensitive and finely tuned that zinc does not have the opportunity to float freely in the cells cytoplasm before it binds to either Zur or ZntR, depending on the cycle.

"The zinc concentration is so low in between pump activity that free-floating zinc just doesnt exist," said Outten, now a post-doctoral researcher at Johns Hopkins Bloomberg School of Public Health. "Its a kinetic process any zinc that shows up in the cell is immediately taken away, to work reactions in the cell, to bind to proteins such as Zur or ZntR or, if no zinc is needed, to be sent packing out of the cell."


'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
6-Jun-2001


Page: 1 2

Related biology news :

1. Chemists at four pharmaceutical companies named Heroes for treating childhood conditions
2. Chemists unlock secret to activating tumor suppressor gene
3. Chemists create unusual lariat RNA, a key intermediate in biological splicing
4. American Institute of Chemists names Ralph Hirschmann AIC Gold Medalist
5. Chemists explore the shape of the key that signals cell division in cancer cells
6. Nanoencapsulation: Chemists at TSRI discover a new and simple way of controlling reactions
7. Chemists spin materials to improve magnetic resonance data
8. Chemists describe "zipper teeth" of DNA molecules -- publish results in the journal Nature
9. Chemists report new approach to synthetic fragments of medically important Heparin
10. Chemists hold national meeting August 22-26
11. Chemists hold national meeting August 22-26 in New Orleans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... Looking ... team-building and cooking events company, offers one-of-a-kind gifts, ranging from gourmet cooking experiences ... California cuisine, and guests leave inspired with new cooking tips and techniques, thanks ...
(Date:4/26/2017)... ... April 26, 2017 , ... Led by ... I clinical trials comes to Tampa, San Francisco and Boston in 2017. ... FDA regulated organizations such as Pfizer Inc., Teva Pharmaceuticals, Advaxis, Inc., Ocular Therapeutix ...
(Date:4/26/2017)... ... April 26, 2017 , ... Baltimore bio ... MailGuardtm mail security screening solution at the National Postal Forum 2017 in Baltimore, ... a fast, highly accurate, easy to use and low cost threat detection solution ...
(Date:4/26/2017)... RESTON, Va. (PRWEB) , ... April 26, 2017 ... ... to make headlines and drive high-level conversations among healthcare industry stakeholders, the discussion ... Healthcare Environment – taking place May 15-18, 2017 in Los Angeles, Calif. Hosted ...
Breaking Biology Technology:
Cached News: