HOME >> BIOLOGY >> NEWS
Chemists report new approach to synthetic fragments of medically important Heparin

ATHENS, Ga. -- Chemists at the University of Georgia have developed a new method of synthesizing the principal constituent units of Heparin, a widely used anti-coagulant that is thought to be involved in numerous biological processes with proteins.

Since Heparin (or its components) is involved with coagulation, growth factor activation and cell adhesion, the research could lead to novel ways to fight disease or improve human health.

Part of the research results were announced this week at the annual meeting of the American Chemical Association in Washington, D.C.

"We have been able to assemble six precursors of the 19 known disaccharides that make up Heparin. These precursors can be used either as donors or acceptors in assembling larger Heparin structures," said chemist Geert-Jan Boons of the University of Georgia's department of chemistry and the Complex Carbohydrate Research Center. "We are not the first to synthesize Heparin fragments, but we are the first to do it using this building-block approach. Our approach is unique in the sense that it can quickly give a vast array fragments."

Colleagues in the research at the University of Georgia are doctoral student Michael Haller and post-doctoral associate Hailong Jiao.

Heparin is a natural polysaccharide that has been used as a medical anti-coagulant for more than half a century. It is isolated commercially from beef lung and pork intestinal mucosa and was discovered some 80 years ago. Worldwide sales of Heparin are well over $2 billion a year. It must be delivered intravenously, though an oral version is in development. Heparin is extremely effective in preventing blood clots following surgery.

Heparin's value is not limited to its anti-coagulant properties, however. There's mounting evidence that Heparin is involved in a dazzling array of biological processes, making the determination of its structure-function relationships a prime target of science. As the Human Genome Project nears
'"/>

Contact: Gert-Jan Boons
gjboons@ccrc.uga.edu
706-542-4401
University of Georgia
23-Aug-2000


Page: 1 2 3

Related biology news :

1. Chemists at four pharmaceutical companies named Heroes for treating childhood conditions
2. Chemists unlock secret to activating tumor suppressor gene
3. Chemists create unusual lariat RNA, a key intermediate in biological splicing
4. American Institute of Chemists names Ralph Hirschmann AIC Gold Medalist
5. Chemists explore the shape of the key that signals cell division in cancer cells
6. Nanoencapsulation: Chemists at TSRI discover a new and simple way of controlling reactions
7. Chemists characterize regulators of zinc intake and export in cells
8. Chemists spin materials to improve magnetic resonance data
9. Chemists describe "zipper teeth" of DNA molecules -- publish results in the journal Nature
10. Chemists hold national meeting August 22-26
11. Chemists hold national meeting August 22-26 in New Orleans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... 2019 , ... VetStem Biopharma has long been ... experience. In November it spun out a human regenerative medicine subsidiary, ... of the first cGMP cell manufacturing facilities in California , VetStem signed ...
(Date:8/6/2019)... ... August 05, 2019 , ... ... announce its attendance at the Microscopy & Microanalysis 2019 Meeting ( M&M 2019 ... Oregon Convention Center. , The Microscopy & Microanalysis Meeting, organized by the Microscopy ...
(Date:8/4/2019)... ... August 02, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL OPERATIONS , August ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... An upcoming ... is scheduled to broadcast 4Q/2019. Check your local listings for more information. , ... generic drug delivery. Focusing on therapeutics for children and the elderly, viewers will ...
(Date:8/14/2019)... COLLEGE, Pa. (PRWEB) , ... August 13, 2019 ... ... in nuclear receptor and in vitro toxicology testing solutions, announced the appointment of ... healthcare industry experience to the Board. , Mark McLoughlin will lend his healthcare ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... for sales and service organizations, today announced that the company’s Studio Intelligent ... for the IVA market . Inference will officially accept the award at Frost ...
(Date:8/6/2019)... DIEGO (PRWEB) , ... August 06, 2019 , ... ... Marketing Radio (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast ... further growth. SDBN BUZZ podcast will also serve to promote the region and ...
Breaking Biology Technology:
Cached News: