HOME >> BIOLOGY >> NEWS
Chemists unlock secret to activating tumor suppressor gene

Researchers have discovered the way to activate a key anti-cancer signal that goes AWOL in several gynecologic and brain cancers.

Since the late 1990s, researchers have known that a gene called PTEN (short for phosphatase and tensin homolog on chromosome 10) encodes a signaling protein that suppresses tumor growth. What wasn't known, however, was what mechanism activated PTEN. The answer was found by a group of researchers led by University of Illinois at Chicago chemistry professor Wonhwa Cho. They report their findings in the June 9 online edition of the Proceedings of the National Academy of Sciences.

"The role of PTEN is to counterbalance the action of an enzyme that induces cell growth," said Cho. "Over-activation of the enzyme can lead to cancer. So if you lose a PTEN gene and its cellular activity, the cell goes out of control. It's like a car with an accelerator but without the brakes."

It was generally thought that PTEN was activated by binding to other proteins, giving it a signal to interact with the cell membrane. But Cho said that's not the case.

Cho's group found that PTEN itself can be activated by phosphorylation, or the chemical addition of a phosphate tag.

"We found that the phosphorylation of certain sites of the PTEN protein worked as a switch to completely change its electrostatic property," said Cho. "It switched from being neutral to positively charged, then recognized the opposite charge on the membrane to bind there." Once the bind took hold, the cancer suppression action went to work.

Cho's laboratory used a biophysical technique called surface plasmon resonance analysis and cellular microscopic analysis of green fluorescence protein-labeled PTEN to unlock the secret of its activation. The UIC chemist believes the mechanism described for PTEN is a relatively common way to regulate membrane binding and activation of many cellular proteins involved in cell signaling and membrane traffickin
'"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
10-Jun-2003


Page: 1 2

Related biology news :

1. Chemists at four pharmaceutical companies named Heroes for treating childhood conditions
2. Chemists create unusual lariat RNA, a key intermediate in biological splicing
3. American Institute of Chemists names Ralph Hirschmann AIC Gold Medalist
4. Chemists explore the shape of the key that signals cell division in cancer cells
5. Nanoencapsulation: Chemists at TSRI discover a new and simple way of controlling reactions
6. Chemists characterize regulators of zinc intake and export in cells
7. Chemists spin materials to improve magnetic resonance data
8. Chemists describe "zipper teeth" of DNA molecules -- publish results in the journal Nature
9. Chemists report new approach to synthetic fragments of medically important Heparin
10. Chemists hold national meeting August 22-26
11. Chemists hold national meeting August 22-26 in New Orleans

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Chemists unlock secret activating tumor suppressor gene

(Date:2/23/2015)... OXFORD, Conn. , Feb. 23, 2015 ... ("NXT-ID" or the "Company"), a biometric authentication company focused ... it has filed provisional patent 62114357 for ... With this patent, NXT-ID introduces a new groundbreaking payment ... and the payment account may only be accessed if ...
(Date:2/18/2015)... -- Cepheid (NASDAQ: CPHD ) today announced that its ... investors to participate via webcast. , Cowen and Company ... March 3, 2015 at 11.20 a.m. Eastern Time , ... Wednesday, March 4, 2015 at 10.25 a.m. Eastern Time ... for these events, please visit Cepheid,s website at http://ir.cepheid.com ...
(Date:2/12/2015)... MINNETONKA, Minn. , Feb. 12, 2015 /PRNewswire/ ... technology company specializing in clinical study management systems, ... Partner Program , further distinguishing iMedNet ... for Clinical Research Organizations (CROs) and healthcare consultants.  ... sales support, prospective customer referrals and numerous co-marketing ...
Breaking Biology News(10 mins):NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3Cepheid to Webcast Upcoming Financial Presentations 2MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2
(Date:2/26/2015)... 2015 According to a new market ... For Transgenic Crops (Corn, Soybean, Cotton and Others), Synthetic ... Share, Growth, Trends and Forecast, 2013 – 2019,”the global ... in 2012 and is expected to reach USD 28,694.1 ... from 2013 to 2019. , Demand for food ...
(Date:2/26/2015)... Regis Technologies announced new potent compound ... substances. , Regis Technologies is proud to announce the ... Suite (PCS) for 2015. , Regis is a contract ... in Morton Grove, Illinois. The PCS addition will provide ... to about one kilogram per batch. , Regis’ ...
(Date:2/26/2015)... , Feb. 26, 2015 Tauriga Sciences, Inc. ... company with interests in the natural wellness sector and ... today that its products will be featured at the ... Partners, 27 th Annual Growth Stock Conference on ... at 1 Ritz Carlton Drive, Dana Point ...
(Date:2/26/2015)... Feb. 26, 2015   Lexicon Pharmaceuticals, Inc. (Nasdaq: ... present at the Cowen 35 th Annual Health Care ... in Boston .  Lexicon management will provide ... A webcast of the presentation will be available through ... the presentation will be available at www.lexpharma.com until ...
Breaking Biology Technology:Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 3Regis Extends cGMP Services to Oncology Market 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 3SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 4Lexicon To Present At The Cowen 35th Annual Health Care Conference 2
Cached News: