HOME >> BIOLOGY >> NEWS
Chemists unlock secret to activating tumor suppressor gene

Researchers have discovered the way to activate a key anti-cancer signal that goes AWOL in several gynecologic and brain cancers.

Since the late 1990s, researchers have known that a gene called PTEN (short for phosphatase and tensin homolog on chromosome 10) encodes a signaling protein that suppresses tumor growth. What wasn't known, however, was what mechanism activated PTEN. The answer was found by a group of researchers led by University of Illinois at Chicago chemistry professor Wonhwa Cho. They report their findings in the June 9 online edition of the Proceedings of the National Academy of Sciences.

"The role of PTEN is to counterbalance the action of an enzyme that induces cell growth," said Cho. "Over-activation of the enzyme can lead to cancer. So if you lose a PTEN gene and its cellular activity, the cell goes out of control. It's like a car with an accelerator but without the brakes."

It was generally thought that PTEN was activated by binding to other proteins, giving it a signal to interact with the cell membrane. But Cho said that's not the case.

Cho's group found that PTEN itself can be activated by phosphorylation, or the chemical addition of a phosphate tag.

"We found that the phosphorylation of certain sites of the PTEN protein worked as a switch to completely change its electrostatic property," said Cho. "It switched from being neutral to positively charged, then recognized the opposite charge on the membrane to bind there." Once the bind took hold, the cancer suppression action went to work.

Cho's laboratory used a biophysical technique called surface plasmon resonance analysis and cellular microscopic analysis of green fluorescence protein-labeled PTEN to unlock the secret of its activation. The UIC chemist believes the mechanism described for PTEN is a relatively common way to regulate membrane binding and activation of many cellular proteins involved in cell signaling and membrane traffickin
'"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
10-Jun-2003


Page: 1 2

Related biology news :

1. Chemists at four pharmaceutical companies named Heroes for treating childhood conditions
2. Chemists create unusual lariat RNA, a key intermediate in biological splicing
3. American Institute of Chemists names Ralph Hirschmann AIC Gold Medalist
4. Chemists explore the shape of the key that signals cell division in cancer cells
5. Nanoencapsulation: Chemists at TSRI discover a new and simple way of controlling reactions
6. Chemists characterize regulators of zinc intake and export in cells
7. Chemists spin materials to improve magnetic resonance data
8. Chemists describe "zipper teeth" of DNA molecules -- publish results in the journal Nature
9. Chemists report new approach to synthetic fragments of medically important Heparin
10. Chemists hold national meeting August 22-26
11. Chemists hold national meeting August 22-26 in New Orleans

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Chemists unlock secret activating tumor suppressor gene

(Date:10/29/2014)... who lose their hair as a consequence of chemotherapy ... improve the scalp cooling technology that prevents hair loss. ... being pioneered by global scalp cooling manufacturing company, Paxman ... biology department of the University of Huddersfield. , The ... who has a background in the pharmacology of cancer ...
(Date:10/29/2014)... research presented at the Society for Integrative Oncology ... for the first time that it is possible ... readily available nutritional supplement, AHCC. ... Smith, Pharm.D., associate professor in the Department of ... of Texas Health Science Center at Houston (UTHealth) ...
(Date:10/29/2014)... Many factors, both genetic and environmental, have been ... of schizophrenia. Some, such as a family history ... infection with Toxoplasma gondii , a parasite ... are still viewed with skepticism. , A new ... and epidemiology at the University of Pennsylvania,s School ...
Breaking Biology News(10 mins):New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3
(Date:10/27/2014)... and TORONTO , Oct. ... www.generex.com ) (OTCQB: GNBT) today announced two presentations ... triggered by its novel proprietary cancer immunotherapeutic AE37 ... breast cancer patients. The AE37 cancer vaccine is ... Express, Inc. ( www.antigenexpress.com ). The presentations are ...
(Date:10/27/2014)... Orlando, Florida (PRWEB) October 27, 2014 ... aims at reducing and eliminating several types of ... have not been achieved in over 30 years ... of Noah's Light Foundation, proves that one mom's ... was diagnosed just before Halloween trick-or-treating, and it’s ...
(Date:10/27/2014)... October 27, 2014 Investor-Edge has ... (NASDAQ: NBIX ), Insmed Inc. (NASDAQ: ... BCRX ), Dyax Corporation (NASDAQ: DYAX ), ... five companies can be accessed at: http://investor-edge.com/register ... Composite ended at 4,483.72, up 0.69%, the Dow Jones ...
(Date:10/25/2014)... 2014 ViaDerma, Inc ... devoted to bringing new products to market, is ... ViaDerma has developed an innovative, patent-pending dual carrier ... transfer of pharmaceutical active ingredients to penetrate the ... localized therapy. The transdermal delivery method also overcomes ...
Breaking Biology Technology:Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 4FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 2FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 3Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 2Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 3Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 4Pre-market Equity Watch on Biotech Industry - Neurocrine Biosciences, Insmed, BioCryst Pharma, Dyax, and Oncothyreon 5ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3
Cached News: