New Orleans, LA -- Lower socioeconomic children are at high risk of developing obesity and type 2 diabetes. The mechanism that contribute to worsening insulin resistance in the growing child are unknown, but mounting evidence suggests a role for adipose derived cytokines and tumor necrosis factor-a (TNF-a), interlukin-6 (IL-6), leptin and resistin. Also of interest has been the recently discovered adiponectin, a peptide hormone derived from adipose (i.e., fat) tissue, which is one of several new hormones involved in obesity and is related to susceptibility to non-insulin dependent (type 2) diabetes).

A new study offers the first findings regarding adiponectin levels in children and their correlations to measures such as body composition and fitness and other obesity related risk factors. The authors of the study, "Relationships Among Adiponectin and Other Adipose Cytokines, Body Composition, and Fasting Insulin In Lower Socioeconomic Middle School Children," are Dan Nemet, MD, Dan M. Cooper, MD and Ping Wang, from the Departments of Pediatrics and Medicine, University of California, Irvine, CA, and Tohru Funahashi, Yuji Matsuzawa, and Sachiyo Tanaka, all from the Department of Internal Medicine and Molecular Science, Osaka, University, Osaka, Japan. They will report their findings in detail during the American Physiological Societys (APS) annual meeting, part of the "Experimental Biology 2002 conference. More than l2,000 attendees will attend the conference which is being held April 20-24, 2002 at the Ernest N. Morial Convention Center, New Orleans, LA.

Methodology
The mechanisms that might contribute to worsening insulin resistance in the growing child are not known, but mounting evidence suggests a role for adipose derived cytokines like tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and the recently discovered adiponectin. The study called for the testing of the hypotheses that these mediators are related to body composi
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Contact: Donna Krupa
703-967-2751
American Physiological Society
23-Apr-2002

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