HOME >> BIOLOGY >> NEWS
Children's Hospital Boston researchers regenerate zebrafish heart muscle

BOSTON -- Experiments on zebrafish provide important clues that could eventually lead to the ability to regenerate damaged human heart muscle, say researchers from the Howard Hughes Medical Institute at Children's Hospital Boston. Reporting in the Dec. 13 issue of Science, a team led by HHMI investigator Mark T. Keating, MD, senior associate, department of Cardiology, showed for the first time that zebrafish can regenerate heart muscle within two months after a severe injury. The team also identified a possible genetic and molecular model for regeneration in zebrafish that could help direct further research in humans. The findings, while still in an early stage, might someday benefit millions of people who suffer heart attacks or experience other forms of cardiac injury.

The zebrafish is the subject of active study because of its ability to regenerate spinal cord, retina, and fins. This finding points to the study of zebrafish heart regeneration as a means to understand and reduce cardiac injury in humans. When a human heart is injured, it cannot "grow back" the damaged muscle, which is instead replaced by scar tissue. Too much scarring can impair the heart's ability to pump and can lead to life-threatening arrhythmias. Keating and his colleagues believe that zebrafish, unlike humans, have especially vigorous development of new heart-muscle cells, or cardiomyocytes. This proliferation of cells regenerates the heart muscle with little or no scarring.

"We think that there's a balance between scar formation and regeneration -- if you regenerate, you don't scar, but if you can't regenerate, you scar," Keating said. "If you inhibit cell proliferation in the zebrafish, the heart doesn't regenerate and instead scars, like in humans. The implication, which isn't proven, but is quite exciting, is that by enhancing human cardiomyocyte proliferation after heart injury, one may be able to enhance cardiac regeneration and reduce cardiac scarring."

In
'"/>

Contact: Elizabeth Andrews
617-355-6420
Children's Hospital Boston
12-Dec-2002


Page: 1 2 3

Related biology news :

1. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer
2. Childrens eating patterns show striking changes in two decades
3. Childrens Memorial, TGen announce partnership
4. Federal grant supports advances in infant heart disease at Childrens Hospital of Philadelphia
5. Packard Childrens Hospital gift creates new biotech research center for childrens health
6. Novel gene therapy on the horizon, says Brenner Childrens Hospital pediatrician
7. Childrens Hospital Boston researchers use therapeutic cloning to create functional tissue in cows
8. Childrens book explores why animals stay home to help
9. Hopkins Childrens Center researchers find cause for common kind of dwarfism
10. Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Childrens Hospital of Philadelphia
11. Immunologist at the Childrens Hospital of Philadelphia receives national award in clinical laboratory immunology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... CHICAGO (PRWEB) , ... July 09, 2020 , ... Today ... Umami Advantage, which will share insight on the “fifth taste” phenomenon that is revolutionizing ... snacks. The Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure ... for glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of ... Fellows are charged with supporting the organization’s initiatives and overall vision. , "Senior ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable ... testing operations in the fight against the COVID-19 pandemic in Zambia. , One ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial Research Network (FSHD ... 2022. The network is a consortium of academic research centers in the United ...
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... Mass. and SOMERSET, N.J (PRWEB) , ... July ... ... leading genome editing company, and Catalent, the leading global provider of advanced delivery ... consumer health products, today announced that they have entered into a strategic partnership ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter ... great surgery is only the beginning of a successful study, while protecting and accessing ... Brad Gien, Global Head of Surgery from Envigo in a live ...
Breaking Biology Technology:
Cached News: