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Cholesterol Anchor Helps Signaling Proteins Direct Development

the surface of the cell that makes it.

"It came as a complete surprise to discover that the cholesterol molecule helps cause the split and then serves as the anchor for the hedgehog signal," says Jeff Porter, Ph.D., a postdoctoral fellow and first author of the paper.

"After spending two years searching for what we thought might be a new molecule, this was like finding out Santa Claus is your dad--hard to believe at first, but after reviewing the data it makes a lot of sense."

The new results could help researchers better understand Smith-Lemli-Opitz syndrome, a serious developmental disorder that strikes approximately one in every 9,000 babies. The disorder disables the body's ability to make cholesterol, producing multiple serious birth defects.

The other study author was Keith E. Young, also of Hopkins and the Howard Hughes Medical Institute.


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Contact: Michael Purdy
mpurdy@welchlink.welch.jhu.edu
410-955-8725
Johns Hopkins Medical Institutions
11-Oct-1996


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