Cholestyramine shows protective effects for marine toxin...( nd more recently to reduce the symptoms...)

Cholestyramine shows protective effects for marine toxin poisoning

nd more recently to reduce the symptoms of certain toxic disorders in humans. In this study, dietary cholestyramine was found to reduce the toxic effects of the algal toxin brevetoxin, in mice.

This therapeutic approach, if proven successful could be anticipated to have the most beneficial outcome to people suffering from ciguatera fish poisoning, a chronic neurotoxic disease resulting from consumption of coral reef fish contaminated with ciguatoxin (a toxin very closely related to the brevetoxin used in this study). Ciguatera, occurs in tropical and subtropical regions worldwide and within the U.S. (South Florida, Hawaii, Caribbean and Pacific territories) and estimated to afflict 177,255 people from 1987-92 at an economic impact of $138 million. Because of the long duration of the symptoms, therapeutic methods are in great demand. These NOAA researchers are concurrently developing a blood detection method to confirm toxin exposure prior to treatment. This research is supported by the National Oceanic and Atmospheric Administration.

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Contact: Sarah Goodwin
eb3press@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
13-Apr-2003

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