HOME >> BIOLOGY >> NEWS
Chromosomal Abnormalities Key For Prediting Leukemia Outcome

COLUMBUS, Ohio -- One of the longest running studies to follow leukemia patients has confirmed that chromosomal abnormalities seen in many of these patients can help determine treatment and predict the likelihood of cure.

The study is a 15-year follow-up of 628 patients with acute myeloid leukemia (AML). This was the first large group of AML leukemia patients for which information on chromosomal abnormalities was prospectively collected. The study of chromosomal abnormalities is known as cytogenetics.

“This study provides stronger evidence for the correlation between cure and a patient’s cytogenetics, and between cytogenetics, survival, and the treatment that patients receive,” said Clara Bloomfield, director of the Ohio State University's Comprehensive Cancer Center and William G. Pace III Professor of Cancer Research.

“It also showed that the majority of patients who were continuously disease-free for five years after diagnosis were cured.”

The study, which was led by Bloomfield, appears in a recent supplement to the journal Cancer. The 628 patients, median age 49 years, had primary AML that was diagnosed between 1980 and 1982.

Median survival of the patients was 7 months, although survival varied significantly according to the chromosomal abnormalities present. For example, patients whose leukemia cells showed a loss of, or damage to, one of the two copies of chromosome 5 or 7 had a median survival of 3 months, while those showing damage to chromosome 16 had a median survival of 18 months.

Of the 628 AML patients in the study, 56 (9 percent) were alive five years after diagnosis. Of these, nine died of AML between 5 and 10 years, one died of AML 11 years after diagnosis, and 7 seven were unavailable for further follow-up.

This left 39 patients, or 6.2 percent, alive 10 to 15 years after their AML diagnosis.

“Thes
'"/>

Contact: Clara Bloomfield
Bloomfield-1@medctr.osu.edu
(614) 293-7048
Ohio State University
26-Mar-1998


Page: 1 2 3

Related biology news :

1. Protecting the rice bowl: Chromosomal mapping of the rice blast fungus
2. Researchers Discover The Pattern Of Inheritance Of Non-Chromosomal DNA
3. Abnormalities in cellular anchoring protein cause fatal heart syndrome
4. Abnormalities in stress hormone response among alcoholics
5. Multi-Center Study Provides Guidelines For Genetic Testing In Women With Breast Cancer: BRCA Abnormalities Multiply Risk Of Ovarian Cancer
6. UB Fertility Researchers Find They Can Predict Pregnancy By Assessing Two Sperm Abnormalities
7. Leukemia stem cells identified by Stanford researchers
8. Newly Discovered Viral Gateway Into Cells Could Play Role In Diagnosis And Treatment Of Leukemia, HIV And Other Viral Diseases
9. Hormone Control Of Rare Leukemia Sheds Light On Molecular Basis Of Cancer
10. New Gene Alteration Find Points To Aggressive Leukemia Treatment
11. Outcome for acute lymphoblastic leukemia linked to gene expression patterns

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/25/2018)... ... December 24, 2018 , ... Researchers at ... discovered a new use for a long-standing computational concept known as “blacklisting,” which ... files and messages. Using blacklisting as a filter to single out genetic variations ...
(Date:12/19/2018)... ... , ... NDA Partners Chairman Carl Peck, MD, announced today that Deb ... Devices and Radiological Health (CDRH), has been appointed a Partner in the firm. Ms. ... has more than 25 years of regulatory experience. In addition to her FDA career, ...
(Date:12/18/2018)... ... 18, 2018 , ... The nation’s leader in stem cell ... technology has been effective at reducing patient acquisition costs by over thirty percent. ... nationwide on patient acquisition marketing programs. Traditional marketing for stem cell patients involves ...
Breaking Biology News(10 mins):
(Date:12/18/2018)... ... December 18, 2018 , ... USDM Life ... the life sciences industry, unveiled a completely redesigned website at http://www.usdm.com . ... browsing experience for their valued clients and business partners. , The website ...
(Date:12/13/2018)... ... , ... Helping conclude Healthy Aging Month this past September, Signia partners with ... Vision and Hearing campaign that sets out to shed light on various ways to ... to destigmatize hearing aids over the years, 9 out of 10 people with mild ...
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic software capable of ... been used to convict a Wyoming man of third-degree sexual assault, a felony punishable ... to test for DNA on the couch cushions on which the sexual assault was ...
(Date:11/26/2018)... ... November 26, 2018 , ... USARAD Holdings Inc., ... Omphalos Venture Partners (Virtual Radiologic founders) among other healthcare investors exhibits at the ... McCormick Place in Chicago. The company is proud to announce a 10 year ...
Breaking Biology Technology:
Cached News: