HOME >> BIOLOGY >> NEWS
Chromosome losses mean poor survival in childhood leukemia

COLUMBUS, Ohio A new international study of children with a severe form of acute lymphoblastic leukemia (ALL) shows that certain chromosome losses can signal an especially poor response to therapy, but that other chromosome abnormalities have no effect on treatment survial.

The finding should enable doctors to identify patients with severe ALL for additional or experimental therapies when such therapies become available. The study was published in the April issue of the journal Leukemia.

"Overall, we found that many chromosome abnormalities in our group of patients made no difference at all, although particular abnormalities could," says Dr. Nyla A. Heerema, a researcher with The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and first author on the study.

"The results surprised us," she says. "We expected that additional chromosome abnormalities would mean a worse outcome."

The retrospective study involved 249 children diagnosed with ALL between 1986 and 1996 by 10 medical centers in the United States and five other countries. The children had received intensive chemotherapy and their disease had gone into complete remission.

All the children had cancers showing the Philadelphia chromosome, an alteration in the genes that indicates a poorer response to treatment. Sixty-one percent of the patients (153), showed secondary chromosome abnormalities; that is, abnormalities present in addition to the Philadelphia chromosome.

Heerema and her colleagues wanted to learn if secondary chromosome abnormalities contributed to a poor prognosis in children with ALL. They found that having most secondary chromosome abnormalities had little affect on a child's prognosis. It did, however, when they involved the loss of chromosome 7, or the part of it known as 7p, or the loss of a part of chromosome 9 known as 9p.

Among children with cancer c
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
4-May-2004


Page: 1 2

Related biology news :

1. Chromosome caps predict bone marrow disease
2. Gene-rich human Chromosome 19 sequence completed
3. Chromosomes are nibbled before they fuse, researchers report
4. Chromosome assessment could predict increased risk of death from age-related disease
5. Chromosome centers defined and sequenced for model plant
6. Discovery: Chromosomes Found To End In Big Loops
7. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer
8. Counting X Chromosomes To Determine Sex
9. Genetic Code Of Chromosome Of Malaria Parasite Deciphered
10. Hopkins And International Team Maps First Major Cancer Gene To X Chromosome
11. UNC Scientists Succeed In Inserting Gene In Human Cells Via Artificial Chromosome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: