HOME >> BIOLOGY >> NEWS
Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt study finds

PITTSBURGH, Sept. 30 The amount of smoke in just one or two puffs of a cigarette can cause breaks in DNA and defects to a cell's chromosomes, leading to irreversible changes in genetic information being passed to a newly divided cell, according to University of Pittsburgh researchers. Their findings, to be reported Tuesday, Oct. 5 at the 35th Annual Meeting of the Environmental Mutagen Society, are the first to show that cigarette smoke causes chromosome instability.

The meeting, "Genes, Mutations and Disease: The Environmental Connection," will be held Oct. 2 to 6 at the Pittsburgh Hilton and Towers.

While most research has focused on the changes in DNA sequence caused by cigarette smoke, little attention has been given to how smoke affects genomic stability of cells. In laboratory studies using human fibroblasts, common cells found in connective tissue, William S. Saunders, Ph.D., and colleagues discovered that exposure to even a small amount of cigarette smoke condensate equal to about 1/25 of a cigarette caused breaks to both strands of DNA and compromised the integrity of the cell's chromosomes.

Cigarette smoke contains some 5,000 organic compounds, including chemicals known to cause cancers. While the researchers did not expose cells to actual puffs of smoke, the cigarette smoke condensate they used was derived from burning real cigarettes and obtained from the R.J. Reynolds Tobacco Company. Containing mostly particulates, the extracted smoke was liquefied as part of a solvent mixture before it was exposed to the cells.

"Double-stranded breaks are considered the most mutagenic type of DNA damage because the broken ends can fuse to other chromosomes in the cell. Chromosome fusion is detrimental to normal chromosome segregation, which in turn leads to genetic imbalances," explained Dr. Saunders, associate professor of biological sciences, University of Pittsburgh School of Arts and Sciences, and a researcher with the Or
'"/>


30-Sep-2004


Page: 1 2 3

Related biology news :

1. Cigarette smoke linked to low folate levels
2. Researchers Find Genetic Connection To Cigarette Smoking
3. Scientists Finger A Molecular Kingpin In Bodys Response To Cigarettes
4. Wildland fires: After the smoke clears
5. UCR study says second-hand smoke affects healing
6. Prenatal exposure to second-handsmoke greater for disadvantaged children, study finds
7. Current smoke alarms pass life-saving tests
8. Physician experts available to speak on California fires and smoke inhalation
9. New technology helps fire managers anticipate smoke problems
10. For those who smoke young...
11. Fears of second-hand smoke confirmed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... , ... July 09, 2020 , ... Today CJ BIO ... which will share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, ... Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM (CDT) during ...
(Date:7/2/2020)... ... 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , a ... for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology Association ... of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 single ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, ... the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga ... supply facility located in Kakegawa, the new 60,000-square-foot facility will provide customers with ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... ... R3 Stem Cell International is now offering patients the opportunity to receive ... patients may choose which extremities they would like treated. , Several studies have shown ... At R3 International, umbilical cord tissue is obtained from a lab with a long ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and ... a strategic partnership whereby Catalent will provide support for the development, manufacturing, and ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech , Gary ... in a one hour live webinar on Thursday, August 13, 2020 at ... drugs and medical devices. Specifically, for medical devices, the NMPA has departments dealing with ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... firm for the life sciences and food industries, is pleased to announce that ... Clinical Research – Business Development. , Charles is an accomplished and results-driven sales ...
Breaking Biology Technology:
Cached News: