HOME >> BIOLOGY >> NEWS
Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt study finds

PITTSBURGH, Sept. 30 The amount of smoke in just one or two puffs of a cigarette can cause breaks in DNA and defects to a cell's chromosomes, leading to irreversible changes in genetic information being passed to a newly divided cell, according to University of Pittsburgh researchers. Their findings, to be reported Tuesday, Oct. 5 at the 35th Annual Meeting of the Environmental Mutagen Society, are the first to show that cigarette smoke causes chromosome instability.

The meeting, "Genes, Mutations and Disease: The Environmental Connection," will be held Oct. 2 to 6 at the Pittsburgh Hilton and Towers.

While most research has focused on the changes in DNA sequence caused by cigarette smoke, little attention has been given to how smoke affects genomic stability of cells. In laboratory studies using human fibroblasts, common cells found in connective tissue, William S. Saunders, Ph.D., and colleagues discovered that exposure to even a small amount of cigarette smoke condensate equal to about 1/25 of a cigarette caused breaks to both strands of DNA and compromised the integrity of the cell's chromosomes.

Cigarette smoke contains some 5,000 organic compounds, including chemicals known to cause cancers. While the researchers did not expose cells to actual puffs of smoke, the cigarette smoke condensate they used was derived from burning real cigarettes and obtained from the R.J. Reynolds Tobacco Company. Containing mostly particulates, the extracted smoke was liquefied as part of a solvent mixture before it was exposed to the cells.

"Double-stranded breaks are considered the most mutagenic type of DNA damage because the broken ends can fuse to other chromosomes in the cell. Chromosome fusion is detrimental to normal chromosome segregation, which in turn leads to genetic imbalances," explained Dr. Saunders, associate professor of biological sciences, University of Pittsburgh School of Arts and Sciences, and a researcher with the Or
'"/>


30-Sep-2004


Page: 1 2 3

Related biology news :

1. Cigarette smoke linked to low folate levels
2. Researchers Find Genetic Connection To Cigarette Smoking
3. Scientists Finger A Molecular Kingpin In Bodys Response To Cigarettes
4. Wildland fires: After the smoke clears
5. UCR study says second-hand smoke affects healing
6. Prenatal exposure to second-handsmoke greater for disadvantaged children, study finds
7. Current smoke alarms pass life-saving tests
8. Physician experts available to speak on California fires and smoke inhalation
9. New technology helps fire managers anticipate smoke problems
10. For those who smoke young...
11. Fears of second-hand smoke confirmed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 8.8% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/20/2017)... Germany , March 20, 2017 At this ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG ... is this year,s CeBIT partner country. At the largest German ... biometrics in use: fingerprint, face and iris recognition as well as DERMALOG´s ... ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... USDM Life Sciences , the leading ... healthcare industries, is pleased to announce Holger Braemer as Vice President of ... GmbH” based in Germany. , Braemer is an integral part of USDM’s expansion ...
(Date:4/20/2017)... ... April 20, 2017 , ... NetDimensions appoints Bill Mastin, a learning ... 20 years of experience in the learning technologies industry, Mastin joins NetDimensions from the ... Technologies Group plc (LTG). At LEO, Mastin served as SVP of the North America ...
(Date:4/20/2017)... ... 2017 , ... Energetiq Technology , a world leader ... Executive Officer (CEO) Debbie Gustafson has been appointed to the SEMI North America ... the electronics manufacturing supply chain. The mission of the SEMI NAAB is to ...
(Date:4/20/2017)... ... April 20, 2017 , ... Open Therapeutics and ... (IP) sharing and commercialization model. , The Center for Advancing Innovation helps institutions ... this effort is bringing the IP to the attention of the entrepreneurial community ...
Breaking Biology Technology:
Cached News: