HOME >> BIOLOGY >> NEWS
Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt study finds

PITTSBURGH, Sept. 30 The amount of smoke in just one or two puffs of a cigarette can cause breaks in DNA and defects to a cell's chromosomes, leading to irreversible changes in genetic information being passed to a newly divided cell, according to University of Pittsburgh researchers. Their findings, to be reported Tuesday, Oct. 5 at the 35th Annual Meeting of the Environmental Mutagen Society, are the first to show that cigarette smoke causes chromosome instability.

The meeting, "Genes, Mutations and Disease: The Environmental Connection," will be held Oct. 2 to 6 at the Pittsburgh Hilton and Towers.

While most research has focused on the changes in DNA sequence caused by cigarette smoke, little attention has been given to how smoke affects genomic stability of cells. In laboratory studies using human fibroblasts, common cells found in connective tissue, William S. Saunders, Ph.D., and colleagues discovered that exposure to even a small amount of cigarette smoke condensate equal to about 1/25 of a cigarette caused breaks to both strands of DNA and compromised the integrity of the cell's chromosomes.

Cigarette smoke contains some 5,000 organic compounds, including chemicals known to cause cancers. While the researchers did not expose cells to actual puffs of smoke, the cigarette smoke condensate they used was derived from burning real cigarettes and obtained from the R.J. Reynolds Tobacco Company. Containing mostly particulates, the extracted smoke was liquefied as part of a solvent mixture before it was exposed to the cells.

"Double-stranded breaks are considered the most mutagenic type of DNA damage because the broken ends can fuse to other chromosomes in the cell. Chromosome fusion is detrimental to normal chromosome segregation, which in turn leads to genetic imbalances," explained Dr. Saunders, associate professor of biological sciences, University of Pittsburgh School of Arts and Sciences, and a researcher with the Or
'"/>


30-Sep-2004


Page: 1 2 3

Related biology news :

1. Cigarette smoke linked to low folate levels
2. Researchers Find Genetic Connection To Cigarette Smoking
3. Scientists Finger A Molecular Kingpin In Bodys Response To Cigarettes
4. Wildland fires: After the smoke clears
5. UCR study says second-hand smoke affects healing
6. Prenatal exposure to second-handsmoke greater for disadvantaged children, study finds
7. Current smoke alarms pass life-saving tests
8. Physician experts available to speak on California fires and smoke inhalation
9. New technology helps fire managers anticipate smoke problems
10. For those who smoke young...
11. Fears of second-hand smoke confirmed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/16/2019)... ... 2019 , ... The Healthcare Technology Report is pleased to ... process was run to evaluate the hundreds of CEOs that lead exemplary organizations ... related areas. We gathered data on each nominee’s professional background and assessed them ...
(Date:4/9/2019)... , ... April 09, 2019 , ... ... clinical outcomes, today announced a new partnership with Ambry Genetics, a leading clinical ... access to state-of-the-art clinical genetic testing and family history assessment, so they may ...
(Date:4/4/2019)... ... , ... The live session taking place on ... between product risk management (ISO 14971) and the clinical risk management process (ISO ... increasing global regulation and reimbursement challenges faced by medical device companies, it is ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... ... April 09, 2019 , ... To support the global fight ... Biohub (CZ Biohub) has chosen Geneious Biologics to help them analyze and compare ... efforts to establish new approaches to inform the discovery of antibody-based diagnostics, new ...
(Date:3/29/2019)... VIEW, Calif. (PRWEB) , ... March 28, 2019 ... ... achievement of development and testing milestones, CARB-X has proceeded with a second stage ... receive up to $1.7 million, which is on top of the $1.7 million ...
(Date:3/27/2019)... WESTBURY, N.Y. (PRWEB) , ... March 27, 2019 , ... ... booth #60 at the Clayton Hotel Burlington Road, Dublin, Ireland. The executive team on ... Future and Pharma 4.0, two key tracks on the agenda this year. , Executives ...
(Date:3/19/2019)... ... 2019 , ... The AACR annual conference pulls together a diverse group of ... cancer research. The Visikol team will be at the show at booth #3252 and ... as their digital pathology services . “For AACR this year we are highlighting ...
Breaking Biology Technology:
Cached News: