Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt s...( en species that form as the cell is exp...)

en species that form as the cell is exposed to the various chemicals in smoke. Treating the smoke-exposed cells with different antioxidants, agents that block formation of reactive oxygen species, prevented most occurrences of anaphase bridge formation and significantly reduced genomic imbalances.

"Unfortunately, no amount of scientific evidence arguing against smoking will get everyone to stop or not begin to smoke in the first place. So, perhaps one long-term goal should be to develop cigarettes that somehow prevent what we've seen happen to the cells in our lab," remarked Dr. Saunders.

In addition to Drs. Luo and Saunders, other authors of the abstract and paper are Kristen M. Werner, Ph.D., a former undergraduate student in the department of biological sciences; and Susanne M. Gollin, Ph.D., professor of human genetics at the University of Pittsburgh Graduate School of Public Health and co-investigator at the Oral Cancer Center of Discovery at the University of Pittsburgh Cancer Institute.

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30-Sep-2004

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