HOME >> BIOLOGY >> NEWS
Circadian clock genes may provide targets for new cancer drugs

A tumor's growth may be controlled by a complex, gene-controlled "clock"-- and jamming that "clock" can offer a new way to fight cancer, according to two studies presented today at the International Conference on Molecular Targets and Cancer Therapeutics organized by the American Association of Cancer Research (AACR), National Cancer Institute (NCI) and European Organisation for Research and Treatment of Cancer (EORTC) in Boston.

Tumor cell circadian clock genes are rhythmically expressed in coordination with rhythmic circadian growth and thereby may represent new therapeutic targets: Abstract 698

Recent research suggests that at least eight central 'clock' genes coordinate many basic functions such as cell proliferation and apoptosis in circadian time, or within each day, according to researchers from the Dorn Veterans Administration Medical Center and the University of South Carolina. Shaojin You, M.D., Ph.D., assistant professor, and his colleagues undertook the first study to establish a relationship between circadian clock gene expression and the growth rate of tumors.

"These results demonstrate that tumor growth itself, as well as cellular and molecular measures of cancer growth, are organized within circadian time," said Dr. You. "Taken in the context of other recent studies, this work indicates that circadian clock genes and their products potentially represent novel targets for the control of cancer growth."

In these studies, some 30 female mice kept on an alternating 12-hour light and 12-hour dark schedule were injected with tumor cells; the rate of tumor growth was subsequently measured to determine the impact of circadian rhythms.

The results showed that "tumors grew on average twice as fast in the 'daily activity/dark circadian phase' than during the 'sleep/light phase' of the [24 hour] circadian cycle," the team reported. The tumor mitotic index, a measure of the proportion of cancer cells actively dividing,
'"/>

Contact: Warren Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
18-Nov-2003


Page: 1 2 3

Related biology news :

1. Circadian clock genes reign in duration of fruit fly copulation
2. Circadian influence in plants more widespread than previously thought
3. Shedding Light On Circadian Rhythms
4. Two Brandeis Scientists Shed Light On The First Photoreceptor Known To Set Circadian Rhythms
5. Glowing Cyanobacteria Gives Researchers New Clues To Circadian Rhythms
6. Researchers Identify New Component Of Circadian Clock
7. Punching the timeclock of life
8. Analysis of biological clock may lead to greater understanding of human disease
9. Testing the fitness of biological clocks
10. Enzyme activation appears key in helping internal clock tell night from day
11. New clock gene uncovered

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Circadian clock genes may provide targets for new cancer drugs

(Date:8/27/2014)... mastodons, short-faced bears, giant ground sloths, saber-toothed cats ... 13,000 years ago at the end of the Pleistocene ... been debated by scientists who, until recently, could only ... including UC Santa Barbara,s James Kennett, professor emeritus in ... collision with Earth played a major role in the ...
(Date:8/27/2014)... began exploring land and evolved into tetrapods today,s amphibians, ... used their fishy bodies and fins in a terrestrial environment ... , Researchers at McGill University published in the journal ... Polypterus , to help show what might have happened when ... Polypterus is an African fish that can breathe air, ...
(Date:8/27/2014)... An invasive grass species frequently found in forests ... then feed on American toads, a new University of ... accidentally introduced to the U.S. in the early 1900s, ... has spread to more than a dozen states in ... along roads and in forests, it can survive in ...
Breaking Biology News(10 mins):Nanodiamonds are forever 2Nanodiamonds are forever 3Walking fish reveal how our ancestors evolved onto land 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3
(Date:8/27/2014)... , Aug. 27, 2014   MSC , ... patient safety, today announced the appointment of Mary ... With 28 years of experience preparing companies for ... 2013 as Executive Vice President of Corporate Development and ... performance improvement business , as well as corporate strategy ...
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... of the "Global Lactic Acid  (Biodegradable Polymer, ... - Trends & Forecasts to 2019" report ... the simplest hydroxyl-carboxylic acid with an asymmetrical carbon ... in the biodegradable polymer, food and beverage, personal ...
(Date:8/27/2014)... -- Guggenheim Securities, the investment banking and capital markets ... veteran equity analyst Charles "Tony" Butler as a managing ... on the biotech/biopharma sector. " Tony Butler ... a broad network of relationships in his industry," said ... of Equities at Guggenheim Securities. "His insights will further ...
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 ... state of the global isotope ratio mass spectrometer industry. ... the industry including definitions, classifications, applications and industry chain ...
Breaking Biology Technology:MSC names Mary Beth Loesch President and CEO 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
Cached News: