HOME >> BIOLOGY >> NEWS
Circadian clock genes may provide targets for new cancer drugs

A tumor's growth may be controlled by a complex, gene-controlled "clock"-- and jamming that "clock" can offer a new way to fight cancer, according to two studies presented today at the International Conference on Molecular Targets and Cancer Therapeutics organized by the American Association of Cancer Research (AACR), National Cancer Institute (NCI) and European Organisation for Research and Treatment of Cancer (EORTC) in Boston.

Tumor cell circadian clock genes are rhythmically expressed in coordination with rhythmic circadian growth and thereby may represent new therapeutic targets: Abstract 698

Recent research suggests that at least eight central 'clock' genes coordinate many basic functions such as cell proliferation and apoptosis in circadian time, or within each day, according to researchers from the Dorn Veterans Administration Medical Center and the University of South Carolina. Shaojin You, M.D., Ph.D., assistant professor, and his colleagues undertook the first study to establish a relationship between circadian clock gene expression and the growth rate of tumors.

"These results demonstrate that tumor growth itself, as well as cellular and molecular measures of cancer growth, are organized within circadian time," said Dr. You. "Taken in the context of other recent studies, this work indicates that circadian clock genes and their products potentially represent novel targets for the control of cancer growth."

In these studies, some 30 female mice kept on an alternating 12-hour light and 12-hour dark schedule were injected with tumor cells; the rate of tumor growth was subsequently measured to determine the impact of circadian rhythms.

The results showed that "tumors grew on average twice as fast in the 'daily activity/dark circadian phase' than during the 'sleep/light phase' of the [24 hour] circadian cycle," the team reported. The tumor mitotic index, a measure of the proportion of cancer cells actively dividing,
'"/>

Contact: Warren Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
18-Nov-2003


Page: 1 2 3

Related biology news :

1. Circadian clock genes reign in duration of fruit fly copulation
2. Circadian influence in plants more widespread than previously thought
3. Shedding Light On Circadian Rhythms
4. Two Brandeis Scientists Shed Light On The First Photoreceptor Known To Set Circadian Rhythms
5. Glowing Cyanobacteria Gives Researchers New Clues To Circadian Rhythms
6. Researchers Identify New Component Of Circadian Clock
7. Punching the timeclock of life
8. Analysis of biological clock may lead to greater understanding of human disease
9. Testing the fitness of biological clocks
10. Enzyme activation appears key in helping internal clock tell night from day
11. New clock gene uncovered

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Circadian clock genes may provide targets for new cancer drugs

(Date:10/16/2014)... synthesis of recent research findings to inform their management ... states. , The Ecology and Management of Moist ... of the Relevant Biophysical Science and Implications for Future ... U.S. Forest Service,s Pacific Northwest Research Station, is a ... synthesis of the large body of scientific information on ...
(Date:10/16/2014)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market announces ... the Smart Wallet, at the 13 th annual ... global conference on the intersection of technology and the ... , founder and publisher of the Strategic News Service™, ...
(Date:10/15/2014)... is spreading rapidly and to an unexpected extent. The ... past and the virus shows a new disease dynamic ... For this reason, the German National Academy of Sciences ... Engineering, and the Union of the German Academies of ... Ebola epidemic today. , In the statement the academies ...
Breaking Biology News(10 mins):New report synthesizes best available science on management of moist mixed-conifer forests 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and By ... the global market on the basis of its ... such as the key drivers, current trends and ... 81 Market Data Tables and 29 Figures spread ... Market by Application and by Geography - Trends ...
(Date:10/18/2014)... Electronic Medical Record (EMR) market report defines and segments the ... The electronic medical record market in the Asian region is ... CAGR of 9.4% from 2013 to 2018. , Browse through ... to get an idea of the in-depth analysis provided. This ... in the same region, and is supported by various tables ...
(Date:10/18/2014)... 2014 The “Global Diagnostic Electrocardiograph ... by End-user (Hospitals, Home/Ambulatory, Research Center, Physician Office, ... -Global Forecast to 2020” provides a detailed overview ... market trends, and strategies impacting the global diagnostic ... of the revenue and share analysis. , The ...
(Date:10/17/2014)... (PRWEB) October 17, 2014 For ... top employers, as published in today’s print issue ... Careers’ annual Top Employers Survey polled employees in ... the 20 best employers. Rankings were determined ... asked to rate their companies on 23 characteristics, ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
Cached News: