HOME >> BIOLOGY >> NEWS
Circadian clock genes may provide targets for new cancer drugs

A tumor's growth may be controlled by a complex, gene-controlled "clock"-- and jamming that "clock" can offer a new way to fight cancer, according to two studies presented today at the International Conference on Molecular Targets and Cancer Therapeutics organized by the American Association of Cancer Research (AACR), National Cancer Institute (NCI) and European Organisation for Research and Treatment of Cancer (EORTC) in Boston.

Tumor cell circadian clock genes are rhythmically expressed in coordination with rhythmic circadian growth and thereby may represent new therapeutic targets: Abstract 698

Recent research suggests that at least eight central 'clock' genes coordinate many basic functions such as cell proliferation and apoptosis in circadian time, or within each day, according to researchers from the Dorn Veterans Administration Medical Center and the University of South Carolina. Shaojin You, M.D., Ph.D., assistant professor, and his colleagues undertook the first study to establish a relationship between circadian clock gene expression and the growth rate of tumors.

"These results demonstrate that tumor growth itself, as well as cellular and molecular measures of cancer growth, are organized within circadian time," said Dr. You. "Taken in the context of other recent studies, this work indicates that circadian clock genes and their products potentially represent novel targets for the control of cancer growth."

In these studies, some 30 female mice kept on an alternating 12-hour light and 12-hour dark schedule were injected with tumor cells; the rate of tumor growth was subsequently measured to determine the impact of circadian rhythms.

The results showed that "tumors grew on average twice as fast in the 'daily activity/dark circadian phase' than during the 'sleep/light phase' of the [24 hour] circadian cycle," the team reported. The tumor mitotic index, a measure of the proportion of cancer cells actively dividing,
'"/>

Contact: Warren Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
18-Nov-2003


Page: 1 2 3

Related biology news :

1. Circadian clock genes reign in duration of fruit fly copulation
2. Circadian influence in plants more widespread than previously thought
3. Shedding Light On Circadian Rhythms
4. Two Brandeis Scientists Shed Light On The First Photoreceptor Known To Set Circadian Rhythms
5. Glowing Cyanobacteria Gives Researchers New Clues To Circadian Rhythms
6. Researchers Identify New Component Of Circadian Clock
7. Punching the timeclock of life
8. Analysis of biological clock may lead to greater understanding of human disease
9. Testing the fitness of biological clocks
10. Enzyme activation appears key in helping internal clock tell night from day
11. New clock gene uncovered

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Circadian clock genes may provide targets for new cancer drugs

(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
(Date:3/31/2015)... March 31, 2015  Elephant Talk Communications Corp. (NYSE ... provider of Software Defined Network Architecture (ET Software DNA® ... revenue of approximately $20.4 million for the year ended ... million for the year ended December 31, 2013. ... Company had completed its multi-year transition away from its ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
(Date:4/16/2015)... San Francisco, CA (PRWEB) April 16, 2015 ... is scheduled to report first quarter results on Thursday, ... the announcement, Cytokinetics’ senior management will host a conference ... and financial results and the company’s outlook for the ... and can be accessed from the homepage and in ...
(Date:4/16/2015)... Regis Technologies looks forward to being ... Research (AACR) annual meeting. Regis will exhibit at this ... April 18, in Philadelphia and running through April 22, ... the oldest and largest organization focused on cancer research. ... partners with survivors to promote awareness and research funding. ...
(Date:4/16/2015)... Mass. , April 16, 2015  In recognition of ... collaborated with hemophilia advocacy groups to illuminate more than 15 ... , including Boston,s Zakim Bridge and ... New Orleans, Mercedes-Benz Superdome and ... occur during the evening of April 17, and coincide with ...
(Date:4/16/2015)... 2015 ChemRar High ... and R&D group, and Lancet, Russian Distribution ... and commercialization of new medicines in ... to stimulate the innovative development of the ... http://photos.prnewswire.com/prnh/20150416/739742-a) ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , ...
Breaking Biology Technology:Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2
Cached News: