Clearing the brain of amyloid peptides

Although the synthesis and pathological role of amyloid peptides are matters of great interest and controversy, the opposing process of amyloid clearance from the brain has received far less attention. Derived from the amyloid precursor protein, the amyloid b1-40 peptide is found in soluble form in the interstitial fluid of the brain, as well as in plaques that form in the brains of individuals with Alzheimers disease (AD). This peptide also interacts with numerous cell surface proteins, such as the LDL receptor-related proteins LRP-1 and -2, and with secreted proteins such as apolipoprotein E. Here, Shibata et al. analyze the kinetics of efflux of this peptide by injecting it in radiolabeled form into the brains of mice. They show that the peptide is cleared from the central nervous system primarily by vascular transport and that the peptide is not degraded by local proteinases but remains stable until it crosses the blood-brain barrier. This vascular transport is significantly less efficient in older mice, suggesting a possible explanation of the age-dependence of AD. The authors also show that interfering with LRP-1 partially blocks the efflux of the peptide, and they suggest that the downregulation of this receptor could account for both the timing and the tissue localization of amyloid in AD patients. Shibata and coworkers have also tested the efflux of amyloid b1-40 peptide in ApoE-deficient mice. Their finding that amyloid clearance is diminished in these mice suggests a previously unsuspected role for ApoE in this disease pathway, distinct from its putative role in amyloidogenesis. If confirmed, this finding could complicate the interpretation of genetic variation in ApoE and its relevance to the risk of AD.


Contact: John Hawley
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Conservation Biology Clearinghouse, Engineering Design Tutor
2. Trial shows which brain cancer patients benefit from temozolomide
3. Targeted therapy knocks out pediatric brain cancer in mice
4. New way to protect brain from stroke damage
5. Chemical signals health of brain cells Symposium
6. DHA-rich diet protects brain from Alzheimers damage, UCLA study shows
7. Decreasing toxins in brains of Alzheimers patients keep cognitive deficits at bay
8. Genetic clues found for common congenital brain disorder
9. Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
10. Molecular therapeutics advance fight against brain cancer
11. Depression traced to overactive brain circuit

Post Your Comments:

(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the ... for Excellence in Volunteer Experience from US2020. , US2020’s mission is to change ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
Breaking Biology Technology:
Cached News: