HOME >> BIOLOGY >> NEWS
Clemson researchers identify mental retardation gene

Clemson University and Greenwood Genetic Center researchers have found a link between a single gene and mental retardation. Dr. Anand K. Srivastava and his colleagues report their findings in the June 28 edition of the internationally respected journal, Science.

The researchers found a single gene, Angiotensin II receptor 2 known as AGTR2 on the X chromosome that may trigger mental retardation when the gene is abnormal. Srivastava, associate research geneticist in Greenwood and adjunct research professor at Clemson, has linked this gene to mental retardation in males.

"The identification of a single gene mutation that may prove to be the cause of some cases of mental retardation is very encouraging," said Duane Alexander, M.D., director of the National Institute of Child Health and Human Development, which funded the study. "This advance not only may lead to insights into a variety of new therapies, but may also help us to better understand the processes involved in normal brain development."

The research was conducted at the Center for Molecular Studies at the J.C. Self Research Institute of Human Genetics in Greenwood. "Identification of genes that cause mental retardation and other human disabilities is a major focus of the institute," said Dr. Charles Schwartz, head of the research program.

A single patient led scientists to research the connection. Knowing beforehand that the mentally retarded female patient had an abnormally arranged X chromosome, they theorized that a single gene was silenced by the rearrangement, resulting in the patient's developmental disabilities. Dr. Srivastava's team identified the gene that was silenced and then studied it in 590 male patients with unexplained mental retardation, identifying mutations in eight of them.

"Although an AGTR2 mutation appeared to be present in only 1.5 percent of males with unexplained mental retardation, this percentage is significant," said James Hanson, M.D
'"/>

Contact: Peter Kent
peter.kent@clemsonews.clemson.edu
864-656-0937
Clemson University
27-Jun-2002


Page: 1 2

Related biology news :

1. Clemson University spin-off uses corn to make plastics, provide cleaner air
2. Clemson researcher places hope on pushy photons
3. Clemson researcher receives Komen grant
4. Clemson University researcher reaches for the stars to prevent osteoporosis
5. Clemson launches S.C. DNA Learning Center
6. Clemson dedicates biotech research complex
7. Breakthrough Clemson research appears in Science
8. Clemson researcher takes part in breakthrough research on insects
9. Clemson researchers find bacteria fighter that does not promote bacterial resistance
10. Clemson researchers create biosensors to protect nations food and water supplies
11. Clemson-led team makes breakthrough in controlling Bt resistance in pests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2019)... FORT WORTH, Texas (PRWEB) , ... January 02, ... ... 2019 catalog. This release is particularly noteworthy, as the life science tools and ... company’s history, it is offering a catalog. The catalog features not just part ...
(Date:12/25/2018)... ... December 24, 2018 , ... Researchers at ... discovered a new use for a long-standing computational concept known as “blacklisting,” which ... files and messages. Using blacklisting as a filter to single out genetic variations ...
(Date:12/19/2018)... (PRWEB) , ... December 19, 2018 , ... ... of a new study in Arthroscopy evaluating the use of novel ... cuff tears (RCTs). These tears represent a painful, disabling condition for which there ...
Breaking Biology News(10 mins):
(Date:1/4/2019)... ... January 02, 2019 , ... ... precancer and cancer cells in blood, has been named as a partner in ... biotech company developing cell therapies for cancer treatment, will use CellMax Life’s circulating ...
(Date:12/19/2018)... ... December 19, 2018 , ... ... first rate Stem Cell Training Course in Las Vegas. Training includes facial rejuvenation, ... procedures explode in popularity nationwide for aesthetics, having the training from expert, Board ...
(Date:12/18/2018)... ... December 18, 2018 , ... ... optimization firm for the life sciences industry, unveiled a completely redesigned website at ... a more user-friendly browsing experience for their valued clients and business partners. ...
(Date:12/13/2018)... Mass. (PRWEB) , ... December 11, 2018 , ... ... biosensor that doctors and nurses can use to quickly detect Clostridium difficile (C. ... be the heart of a handheld device that can be used onsite in ...
Breaking Biology Technology:
Cached News: