Clock cues: Cellular sensing, metabolism research wins Amersham Biosciences and Science Prize

All of us live our lives on the circadian clock, an interacting group of molecules that regulates the body's activities on a 24-hour cycle. This daily rhythm can be influenced by environmental cues-such as light, energy status, and food availability-through a special cellular sensing system described for the first time by Jared P. Rutter of the University of Texas Southwestern Medical Center, winner of this year's $25,000 Young Scientist Prize awarded by Amersham Biosciences and Science.

These discoveries point to "a way for an organism, down at the cellular level, to respond to changes in its environment in a fairly rapid way, and to maintain its proper activity rhythm," said Rutter, who noted that changes in the circadian cycle in humans have been associated with sleep disorders and depression.

Rutter and his Ph.D. advisor Steven L. McKnight arrived at the UT Southwestern lab at the same time with no established projects to work on and the freedom to explore research problems that few other labs were pursuing.

"That's been one of the most exciting, and most rewarding, parts of my work, to look back at starting from scratch and actually see some headway in understanding the biology," said Rutter.

"Biological rhythms and their underlying mechanisms have become an exciting domain in neuroscience and cell biology. Rutter's work has provided an important new insight that will enhance the excitement," said Science Editor-in-Chief Donald Kennedy.

Rutter examined two proteins in his research, both containing a "sensing" domain known as a PAS domain. The first protein, NPAS2, is involved regulating the body's 24-hour cycle. Rutter discovered that NPAS2 acts as a bridge between the expression of circadian cycle genes and the cell's metabolic environment, by linking itself to a heme molecule that acts as a gas sensor in the cell. Production of gases like carbon monoxide is likely to fluctuate depending on a cell's metabolic activity.

Contact: Lisa Onaga
American Association for the Advancement of Science

Page: 1 2 3 4

Related biology news :

1. Clock cells, tumor suicide, tailored therapies among subjects of AACR-NCI-EORTC Conference
2. Clock tells time at such speed that reading it becomes challenge
3. Scientists Devise Method To Address Conflict Between Molecular Clock, Fossil Record Of Mammalian Evolution
4. Clockwork Clues Determined
5. Researchers Identify New Component Of Circadian Clock
6. Researchers Show Mechanism And Similarities Of Biological Clocks
7. Hopkins Scientists Clock The Speed Of Comprehension
8. Scientists Discover Proteins Which Help Set The Bodys Clock
9. Biological Clocks No Longer Found Only In The Brain
10. Cellular problems found behind complex obesity syndrome
11. Cellular fat sensor slows heart disease

Post Your Comments:

(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle school teachers ... Scholar Program, a unique professional development program that provides advanced STEM (science, technology, ... science teachers nationwide. , Created in partnership between the National Stem Cell Foundation ...
(Date:7/31/2020)... ... 30, 2020 , ... Justin Zamirowski to lead upcoming launches ... focus on Type 2 diabetes and associated comorbidities. , Justin brings over 20 ... classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ efforts ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues ... An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, ... the most effective way to complete one? Will the study comply with all ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... chain validation engineering firm, is making available for free its new white ... incorporate concurrent transport simulation testing into today’s biologics licensing application (BLA). In ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now ... With 50 million stem cells total, patients may choose which extremities they would like ... arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained ...
(Date:7/31/2020)... ... , ... eSource has long been touted as the solution to high data ... the reasons it did not take off as quickly as people initially expected, and ... moving towards capturing data electronically for clinical trials and then repurposing it for downstream ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new technology ... technology of its kind on the market and we were pleased that the IFT ... of traditional cultured ingredients, creating a natural way to extend the shelf life and ...
Breaking Biology Technology:
Cached News: