Cloning reverses aging in cow cells, a milestone in medical research

Vincent J. Cristofalo, Ph.D., president and CEO of the Lankenau Institute for Medical Research, and his colleague Mary Kay Francis, Ph.D., were among the investigators involved in an important cloning study that will be released later this week in the journal Science. In this report, the researchers described how they used a new cloning technique to rewind the aging clock in cells. The clock is considered to be the strand of DNA at the end of each chromosome (called telomeres), and is shortened every time a cell divides. When the aging clock runs out, the cells stop dividing.

Medical science has long sought to discover a "Fountain of Youth" that could potentially turn back the aging clock to return old cells to their earliest stages of development. If accomplished, this will have tremendous implications for regenerating cells and tissues in order to repair age-related damage. However, the results of previous research that resulted in Dolly the cloned sheep (created by a different cloning method) reported that she was actually aging faster and that her aging clock had not been reset.

The report in Science describes the cloning of six calves from old (senescent) cells at the end of their aging clock (lifespan). Cells taken from these animals not only show a return to a more youthful state, but they actually exhibited a longer lifespan. Cristofalo and Francis used multiple criteria from their expertise in studying changes that occur in the cellular aging process to confirm the age of the donor cells that Advanced Cell Technology, Inc. (ACT) used for its nuclear transfer experiments. ACT produced six healthy cloned calves from these donor senescent cells.

"The significance of this finding is that you can, in essence, reset the aging clock in animal cloning, a development which overturns a previous obstacle to effective cloning. The study establishes a basis for far more kinds of cloning experiments that could have significant implications in medicine and

Contact: Laura Feragen
Thomas Jefferson University

Page: 1 2

Related biology news :

1. Cloning pigs and drug discovery among hot topics
2. Cloning chip
3. Cloning primates is turning out to be a real challenge
4. Cloning can turn back the developmental clock
5. Cloning reverses aging in cow cells, Scienceauthors say
6. First Reproducible Cloning Of Mammals From Adult Cells Reported In Nature
7. Human Cloning: Grappling With Reality Penn Bioethicist To Explore The Facts Behind The Hysteria
8. The Cloning of Humans On The Adoption Model: Penn Bioethicist Will Present A Model For Future Laws Involving Human Cloning
9. UNESCO Director-General Reaffirms That Human Cloning Is Contrary To Human Dignity
10. Human Cloning: International Bioethics Committee President Stresses Political And Moral Commitment
11. Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model

Post Your Comments:

(Date:8/26/2020)... ... ... Modality Solutions, a biopharmaceutical cold chain validation engineering firm, is pleased to ... most prestigious ranking of the nation’s fastest-growing private companies. Modality Solutions made the Inc. ... growth of 71 percent. , The Inc. 5000 list represents a unique look ...
(Date:8/21/2020)... LEXINGTON, Mass. (PRWEB) , ... August 18, 2020 ... ... novel approaches to cell therapy, today announced that the U.S. Food and Drug ... evaluation of Sentien’s lead asset, SBI-101, for the treatment of severe COVID-19. Approval ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... and expo uniting life science, data science, informatics and IT leaders goes VIRTUAL ... this period of uncertainty and change, Bio-IT takes the leadership role of keeping ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... , ... Bio-IT World has announced the winners of the ... of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were honored. ... examples of how technology innovations and strategic initiatives can be powerful forces for ...
(Date:7/1/2020)... BOWLING GREEN, Ohio (PRWEB) , ... June 29, ... ... cooperative that offers access to competitively procured purchasing contracts to its membership, recently ... BioFit to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria ...
(Date:6/28/2020)... , ... June 25, 2020 , ... The Indoor Lab, ... of Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy ... , A Safe Space™ enabled business will provide a health performance index system ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
Breaking Biology Technology:
Cached News: