HOME >> BIOLOGY >> NEWS
Closing in on treatment for Charcot-Marie-Tooth disease?

Charcot-Marie-Tooth (CMT) is a hereditary disorder of the peripheral nervous system that strikes 1 person in every 2500. Increasing debilitation of the muscles ultimately leads to their disappearance in the lower legs, feet and hands. Now, researchers from VIB (the Flanders Interuniversity Institute for Biotechnology) have discovered a piece of the molecular puzzle of this disease. Two small 'heat shock' proteins turn out to be crucial - faults in the coding genes lead to the disease. Additional research has shown that these proteins play an important role in many other neurodegenerative disorders as well. This research moves us a step closer to the development of new therapies.

CMT, a serious disorder without a cure

CMT, the most common hereditary disorder of the peripheral nervous system, leads to debilitation of the muscles in the lower legs, feet and hands. The clinical picture is extremely variable, but older patients sometimes require a wheelchair. Today, only supportive treatment is available; there are still no effective therapies to retard or stop the progress of the disease. More insight into the molecular processes of this disease is essential for diagnosis and potential treatment. And exploration of the genes involved is a crucial step in this.

VIB research findings

Joy Irobi and her colleagues - under the direction of Vincent Timmerman and Peter De Jonghe of the Department of Molecular Genetics, University of Antwerp - are concentrating on the genetic and biological study of hereditary disorders of the peripheral nervous system. The largest cells in our body, our peripheral neurons can be 1 meter long in bundles of nerve fibers extending from the spinal cord to the feet.

Recently, the researchers in Antwerp have found mutations in the genetic code of two small 'heat shock' proteins (HSPs) in a number of people with CMT. In stress situations, cells produce HSPs that act as 'chaperones', stabilizing
'"/>

Contact: Ann Van Gysel
ann.vangysel@vib.be
32-9-244-6611
VIB, Flanders Interuniversity Institute of Biotechnology
7-May-2004


Page: 1 2

Related biology news :

1. Closing in on the cellular culprits of schizophrenia
2. Researchers Closing In On Gene For Paralytic Disorder
3. Leader in cancer treatment and prevention research honored
4. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. New treatment for fibromyalgia
7. The impact of genetic variations on the treatment of early rheumatoid arthritis
8. OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
9. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
10. Colleagues to recognize research leadership in cancer detection, prevention and treatment
11. New view of leukemia cells identifies best treatment options, Stanford researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... , March 20, 2017 PMD Healthcare ... personal spirometer and Wellness Management System (WMS), a remote, ... Founded in 2010, PMD Healthcare is a Medical Device, ... a mission dedicated to creating innovative solutions that empower ... With that intent focus, PMD developed the first ever ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
(Date:3/7/2017)... 7, 2017   HireVue , the leading provider ... identify the best talent, faster, today announced the additions ... (CSO) and Diana Kucer as Chief Marketing ... executive team poised to drive continued growth in the ... year of record bookings in 2017. "Companies ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... ... secure electronic informed consent (eConsent) solution that simplifies research studies, accelerates study startup, ... division of Quorum, Q Consent™ is the first and only IRB-integrated eConsent ...
(Date:4/27/2017)... New Orleans, La. (PRWEB) , ... ... ... Polymer Monitoring Technologies today announced a comprehensive rebrand and a name change ... products for the industrial and laboratory monitoring of polymer and biopharmaceutical manufacturing ...
(Date:4/27/2017)... , April 27, 2017  Kinexum, a distinguished ... products, today announces the appointment of Thomas C. ... Alexander ("Zan") Fleming, M.D., Kinexum founder, who becomes Executive ... advisor to Kinexum clients. Thomas Seoh ... on the Kinexum mission and lead the firm,s remarkable ...
(Date:4/26/2017)... , ... April 25, 2017 , ... LABS, Inc. (LABS) ... were added to its extensive test menu: Nucleic Acid Testing (NAT) for ZIKV; and ... was only able to offer NAT screening for blood donors under an Investigational New ...
Breaking Biology Technology:
Cached News: