HOME >> BIOLOGY >> NEWS
Clue found on breast tumors distinguishes patients with better survival odds

Washington, D.C. Cancer researchers at Georgetown University Medical Center have discovered a key marker in breast cancer tumors that may help determine which women with early stage breast cancer have a better chance of survival. The research appears in the June 1 issue of the Journal of Clinical Oncology.

Although survival rates for early-stage breast cancer patients have improved over the last five years, many women still die from the disease. In this new study, the Georgetown team found that women whose tumors retain Stat5, a protein biomarker, have a highly favorable prognosis and may be cured by surgery and local therapy alone instead of additional regiments of chemotherapy or anti-estrogen therapy. Conversely, women whose tumors lost the Stat5 marker had a 7.6-fold increased risk of dying from recurrent breast cancer.

"Detection of the Stat5 marker in early stage breast cancer may lead to improved individualized therapy," said Hallgeir Rui, M.D., Ph.D., associate professor of oncology, Lombardi Comprehensive Cancer Center at Georgetown and principal investigator of the study. "This may include more careful follow-up and more aggressive treatment of patients at higher risk of breast cancer recurrence, and reduced treatment in patients with excellent prognosis."

Rui notes that the majority of promising breast cancer markers that have been identified over the last decade have failed to become useful in the clinical setting after follow-up studies. However, the design and results of this study give Rui and his colleagues room for optimism.

The study involved a retrospective analysis of two large, independent breast cancer patient materials that included over 1,100 patients, giving the study a solid statistical basis. Also, unlike some marker assays or tests, the assay for Stat5 is simple, inexpensive, and can be rapidly adapted to routine analysis in pathology laboratories using standard procedures.

"A
'"/>

Contact: Elizabeth McDonald
eem6@georgetown.edu
202-687-7707
Georgetown University Medical Center
28-May-2004


Page: 1 2

Related biology news :

1. New signs of life found at the Poles
2. Key cell-death step found
3. European common frog found to use novel mating strategy
4. Byproduct of water-disinfection process found to be highly toxic
5. Genuine stem cells found in skin might treat hair loss, wounds
6. Flame retardants found on supermarket shelves
7. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
8. Genetic clues found for common congenital brain disorder
9. New clues to hereditary blinding disease found
10. Anti-bacterial additive found in Maryland streams
11. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... They call it the “hairy ball.” ... depiction of a system of linkages and connections so complex and dense that ... computer science at Worcester Polytechnic Institute (WPI) and director of the university’s bioinformatics ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... announced today that they have entered into a multiyear collaboration to identify and ... researchers with additional tools for gene editing across all applications. , Under the ...
(Date:10/12/2017)... ca (PRWEB) , ... October 12, 2017 , ... ... the Surgical Wound Market with the addition of its newest module, US Hemostats ... $1.2B market for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
Breaking Biology Technology:
Cached News: