HOME >> BIOLOGY >> NEWS
Clues To Transplant Tolerance Linked To Infectious Disease Immunity Cell Traffic Key, Say Authors In New England Journal of Medicine

PITTSBURGH, Dec. 23 -- The process by which the human immune system takes little notice of certain infections is similar to the way it takes little notice of a transplanted organ under the most perfect immunological conditions, say two authors, one a Nobel laureate and the other the "father of transplantation," in this week's New England Journal of Medicine.

Thomas E. Starzl, M.D., Ph.D., professor of surgery and director, University of Pittsburgh Thomas E. Starzl Transplantation Institute; and Rolf M. Zinkernagel, M.D., professor of pathology and director, Institute for Experimental Immunology, University of Zurich, report that the mechanisms by which certain micro-organisms are able to exist in the human host closely resemble the mechanisms that confer permanent acceptance of a transplanted organ.

That antigens-foreign substances like those in micro-organisms and cells from a donor organ-migrate through the body to take up residence in various tissues is the common thread that explains how the body's immune system responds to both infectious diseases and organ transplants. The authors say this mechanism, involving a delicate balancing act, governs the immune system's response or nonresponse against infections, tumors, self, and transplanted organs from either human or animal donors.

"Although the relation between infection and transplantation immunity is complicated, the mechanisms and rules are basically the same," the authors write.

The review article is a convergence of theories from two separate medical specialties and draws upon the seminal works of Drs. Starzl and Zinkernagel.

In a 1992 Lancet article, Dr. Starzl observed that chimerism-the coexistence of donor and recipient immune cells-was a condition present in transplant recipients who had survived with their transplanted organs for up to 29 years. Donor leukocytes (white blood cells) and dendritic cells, which originate in bone
'"/>

Contact: Lisa Rossi
rossiL@msx.upmc.edu
412-647-3555
University of Pittsburgh Medical Center
23-Dec-1998


Page: 1 2 3 4

Related biology news :

1. How wounds heal Clues from flies
2. Shadow proteins in thymus - Clues to how immune system works?
3. Clues to the evolution of photosynthesis
4. Clues from analysis of fish bones supports theory of climate shift 5000 years ago, onset of El Nio
5. Clues to development of eyes light-sensitive cells found
6. Fossilized Emu Eggshells Give Clues To 65,000 Years Of Vegetation And Climate Changes In Australia
7. Ant-Fungus Relationship May Provide New Clues About Antibiotics
8. Jumpin Jordan! Athletic Gene Yields Biological Clues
9. Structure Of Fat-Depleting Protein Reveals Important Functional Clues
10. Model Polymers Reveal New Clues to Protein Folding
11. Study Finds Protein Clues To Early Embryo Development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/20/2018)... Calif. (PRWEB) , ... November 19, 2018 , ... ... Emsculpt in the Bay Area -- the first and only non-invasive buttock ... contractions, Emsculpt is FDA cleared to strengthen, tone and firm the buttocks to ...
(Date:11/16/2018)... ... November 16, 2018 , ... ... was awarded the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby Advocacy Award at ... Advocacy Award, named “The Selby” after longtime IBWA contributor Shayron Barnes-Selby, is awarded ...
(Date:11/15/2018)... ... November 14, 2018 , ... Researchers at ... speeds up the analysis and publication of biomedical data from many months or ... Until now, the primary method available to share biomedical research data has been ...
Breaking Biology News(10 mins):
(Date:11/29/2018)... ... 2018 , ... RAGS, today announced the closing of a $1.5 million Second ... existing investor and board member Jeremy Andrus, CEO of Traeger Grills, as well as ... enable the company to accelerate its growth and expand the product line. RAGS has ...
(Date:11/20/2018)... ... 2018 , ... Patients with missing teeth in Sandy Springs, GA, Alpharetta, GA, ... Myers at THE DENTIST Centers without a referral. Dr. Myers is a skilled cosmetic ... years. He now offers skilled dental care in two practice locations THE DENTIST Windward ...
(Date:11/13/2018)... ... 2018 , ... AseptiScope(TM), Inc. announces it is advancing its ... last week, confirm pose a significant health risk. The two large clinical ... are often improperly or rarely disinfected. In the AJIC November 6 issue, investigators ...
(Date:11/11/2018)... SAN DIEGO (PRWEB) , ... November 09, 2018 , ... ... named a CES® 2019 Innovation Awards Honoree for DFree ®, the ... and notifies you when it’s time to go to the bathroom. The announcement was ...
Breaking Biology Technology:
Cached News: