Clues to development of eye's light-sensitive cells found

ke up almost 95% of the photoreceptors in human retina. Much less is known about cones, including the important but puzzling question as to why they do not generally survive without rods in diseases like RP.

Swaroop believes that the Nrl knockout mouse - that is, the mouse bred to have only cone cells - can be used to investigate this behavior. Even though the mice do not have a well-defined macula (a region of the retina that is richer in cones than other parts of the retina), Kellogg researchers hope that this mouse model will allow them to identify the molecules needed for cone function and survival. This knowledge holds promise for developing treatments for macular degeneration, a disease in which photoreceptors in the macular area of the retina die off.

As part of the study, researchers also examined the effect of age on cone function in the absence of rods, recording electrical activity in the retina of Nrl knockout mice at different times after birth. The responses did not change significantly up to 31 weeks, suggesting that cones can survive without rod function. This finding has encouraged Swaroop and colleagues to continue to explore how to keep cones alive longer.

The Nrl gene was discovered by Swaroop's group in 1991 at the Kellogg Eye Center. Over the years, his laboratory has shown that Nrl is a key molecule, which controls the expression of rod-specific genes, including rhodopsin, the visual pigment contained in rods.

Recently, Prabodha K. Swain, Ph.D., a post-doctoral fellow at Kellogg, working with investigators at University of Pennsylvania and in France, showed that Nrl is present only in rods and not in cones. While these investigations were in progress, Mears started to develop the Nrl-knockout mouse to study the role of Nrl in a living animal.

During development, retinal stem cells differentiate into photoreceptors in response to external and internal cues. Since Nrl is needed for rods to develop, it w

Contact: Kara Gavin
University of Michigan Health System

Page: 1 2 3

Related biology news :

1. How wounds heal Clues from flies
2. Shadow proteins in thymus - Clues to how immune system works?
3. Clues to the evolution of photosynthesis
4. Clues from analysis of fish bones supports theory of climate shift 5000 years ago, onset of El Nio
5. Fossilized Emu Eggshells Give Clues To 65,000 Years Of Vegetation And Climate Changes In Australia
6. Ant-Fungus Relationship May Provide New Clues About Antibiotics
7. Jumpin Jordan! Athletic Gene Yields Biological Clues
8. Structure Of Fat-Depleting Protein Reveals Important Functional Clues
9. Model Polymers Reveal New Clues to Protein Folding
10. Study Finds Protein Clues To Early Embryo Development
11. New Clues To Evolution Of Human Brain

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: