HOME >> BIOLOGY >> NEWS
Cocaine harms brain's 'pleasure center,' addict study finds

Finding may aid understanding of addiction, depression, normal aging

ANN ARBOR, MI New research results strongly suggest that cocaine bites the hand that feeds it, in essence, by harming or even killing the very brain cells that trigger the "high" that cocaine users feel.

This first-ever direct finding of cocaine-induced damage to key cells in the human brain's dopamine "pleasure center" may help explain many aspects of cocaine addiction, and perhaps aid the development of anti-addiction drugs. It also could help scientists understand other disorders involving the same brain cells, including depression.

The results are the latest from research involving postmortem brain tissue samples from cocaine abusers and control subjects, performed at the University of Michigan Health System and the VA Ann Arbor Healthcare System. The paper will appear in the January issue of the American Journal of Psychiatry.

"This is the clearest evidence to date that the specific neurons cocaine interacts with don't like it and are disturbed by the drug's effects," says Karley Little, M.D., associate professor of psychiatry at the U-M Medical School and chief of the VAHS Affective Neuropharmacology Laboratory. "The questions we now face are: Are the cells dormant or damaged, is the effect reversible or permanent, and is it preventable?"

Little and his colleagues report results from 35 known cocaine abusers and 35 non-drug users of about the same age, sex, race and causes of death. Using brain samples normally removed during autopsy, the researchers measured several indicators of the health of the subjects' dopamine brain cells, which release a pleasure-signaling chemical called dopamine. The cells interact directly with cocaine.

The team looked at levels of a protein called VMAT2, as well as VMAT2's binding to a selective radiotracer molecule, and overall dopamine level.

In all three, cocaine users' levels were signif
'"/>

Contact: Kara Gavin
umhsmedia@umich.edu
734-764-2220
University of Michigan Health System
1-Jan-2003


Page: 1 2 3 4 5

Related biology news :

1. Cocaine use in warm environments impairs bodys cooling mechanisms -- and can be lethal
2. Cocaine use while pregnant may cause ADHD
3. Fruit Flies May Shed Light On Cocaine Addiction
4. Imaging Studies Illuminate Brains Response To Cocaine
5. OHSU Scientists Discover Mice Lacking Dopamine Receptor Are Supersensitive To Alcohol, Cocaine And Methamphetamine
6. Rock climbing harms cliff ecosystems
7. Making sense of the brains mind-boggling complexity
8. The brains flashy tale
9. Leptin rewires the brains feeding circuits
10. Estrogen promotes gender differences in brains response to stress
11. Pain and the brain: Sex, hormones & genetics affect brains pain control system

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... 2, 2017 Summary This report provides ... its partnering interests and activities since 2010. ... Read the full report: ... since 2010 report provides an in-depth insight into the partnering ... On demand company reports are prepared upon purchase ...
(Date:3/2/2017)... 2017 Who risk to be deprived of ... full report: https://www.reportbuyer.com/product/4313699/ WILL APPLE AND ... Fingerprint sensors using capacitive technology represent a fast ... Idex forecasts an increase of 360% of the number ... the fingerprint sensor market between 2014 and 2017 (source ...
(Date:3/1/2017)... -- Aware, Inc. (NASDAQ: AWRE), a leading supplier of biometrics ... has resigned, effective March 3, 2017, as co-Chief ... Treasurer of Aware citing a desire to retire.  Mr. ... the Board of Directors of Aware. ... co-President, General Counsel has been named Chief Executive Officer, ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... Pa. , March 29, 2017 Patients ... which is why CSL Behring awards Local Empowerment for ... rare disease patient groups. These groups tackle complex legislative ... heard on Capitol Hill and in statehouses across the ... the community-based grant was awarded to New England Hemophilia ...
(Date:3/29/2017)... , and HILDEN, Germany , March 29, 2017 /PRNewswire/ ... FRANKFURT PRIME STANDARD: QIA) today announced the U.S. launch of ... JAK2 assay), which was cleared by the U.S. Food and Drug Administration as ... allele in genomic DNA extracted from EDTA whole blood.* ... The ipsogen JAK2 assay is processed on QIAGEN,s Rotor-Gene ...
(Date:3/29/2017)... 29, 2017 /PRNewswire/ - Last year,s petition to the White ... only efforts active to generate awareness on the importance of new ... in the healthcare market place. ... Earlier this month Health Advance (OTC ... pharmaceutical and nutritional products, announced its endeavors on this generally ...
(Date:3/29/2017)... N.J. and PETACH TIKVAH, ...  BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), ... technologies for neurodegenerative diseases, announced financial results ... "2016 was a highly successful ... important achievements and significant progress made on ...
Breaking Biology Technology:
Cached News: