HOME >> BIOLOGY >> NEWS
Cocaine harms brain's 'pleasure center,' addict study finds

Finding may aid understanding of addiction, depression, normal aging

ANN ARBOR, MI New research results strongly suggest that cocaine bites the hand that feeds it, in essence, by harming or even killing the very brain cells that trigger the "high" that cocaine users feel.

This first-ever direct finding of cocaine-induced damage to key cells in the human brain's dopamine "pleasure center" may help explain many aspects of cocaine addiction, and perhaps aid the development of anti-addiction drugs. It also could help scientists understand other disorders involving the same brain cells, including depression.

The results are the latest from research involving postmortem brain tissue samples from cocaine abusers and control subjects, performed at the University of Michigan Health System and the VA Ann Arbor Healthcare System. The paper will appear in the January issue of the American Journal of Psychiatry.

"This is the clearest evidence to date that the specific neurons cocaine interacts with don't like it and are disturbed by the drug's effects," says Karley Little, M.D., associate professor of psychiatry at the U-M Medical School and chief of the VAHS Affective Neuropharmacology Laboratory. "The questions we now face are: Are the cells dormant or damaged, is the effect reversible or permanent, and is it preventable?"

Little and his colleagues report results from 35 known cocaine abusers and 35 non-drug users of about the same age, sex, race and causes of death. Using brain samples normally removed during autopsy, the researchers measured several indicators of the health of the subjects' dopamine brain cells, which release a pleasure-signaling chemical called dopamine. The cells interact directly with cocaine.

The team looked at levels of a protein called VMAT2, as well as VMAT2's binding to a selective radiotracer molecule, and overall dopamine level.

In all three, cocaine users' levels were signif
'"/>

Contact: Kara Gavin
umhsmedia@umich.edu
734-764-2220
University of Michigan Health System
1-Jan-2003


Page: 1 2 3 4 5

Related biology news :

1. Cocaine use in warm environments impairs bodys cooling mechanisms -- and can be lethal
2. Cocaine use while pregnant may cause ADHD
3. Fruit Flies May Shed Light On Cocaine Addiction
4. Imaging Studies Illuminate Brains Response To Cocaine
5. OHSU Scientists Discover Mice Lacking Dopamine Receptor Are Supersensitive To Alcohol, Cocaine And Methamphetamine
6. Rock climbing harms cliff ecosystems
7. Making sense of the brains mind-boggling complexity
8. The brains flashy tale
9. Leptin rewires the brains feeding circuits
10. Estrogen promotes gender differences in brains response to stress
11. Pain and the brain: Sex, hormones & genetics affect brains pain control system

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cocaine harms brain pleasure center addict study finds

(Date:3/17/2015)... 2015  MecklerMedia Corporation (OTCQX: MECK) announced its ... robots ever held in New York ... 11-13, 2015 at the Javits Convention Center. ... include: Acorn Product Development; Axis NJ; c-Link Systems; ... Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; ...
(Date:3/12/2015)... 12, 2015 Beta Systems ... and access management (IAM) solution for a fixed ... Beta System,s new IAM package, customers benefit from ... from multiple IAM implementations across different industries. The ... well as any necessary services and consulting. It ...
(Date:3/10/2015)... -- Continuing its 167-year history of offering the Best, the ... Eye Scanning Password Authenticator , a device that confirms ... or sensitive data. Employing the same biometric ... device has a small camera that scans and saves ... them into an encrypted ID that cannot be forged ...
Breaking Biology News(10 mins):MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
(Date:3/29/2015)... 29, 2015 As a symbol of ... by our pharmaceutical manufacturing clients, Whitehouse Laboratories is excited ... the Berkenstock Race Team for the 2015 race season. ... speed, but a strong sense of precision and attention ... to success in the quality control testing laboratory. Sponsorship ...
(Date:3/27/2015)... March 27, 2015 The consumption of ... of the recession and high prices in 2008. However, ... recovered and keeps on gaining momentum now. , To ... at more than 100,000 thousand tonnes. No considerable growth ... the global capacity rocketed during 2012-2013, registering 11% growth ...
(Date:3/27/2015)... March 27, 2015  Neogen Corporation (NASDAQ: NEOG ... a prearranged trading plan in accordance with Securities and ... and CEO of Neogen Corporation, is a minority owner ... common stock. Herbert does not have control ... The filing is only for a portion of the ...
(Date:3/27/2015)...  Peter Walter was chosen as winner of the ... on how proteins are transported between cellular compartments and ... cells use to handle stress tied to the aggregation ... biochemistry at the University of California, San Francisco. His ... human diseases related to defective protein folding and transport. ...
Breaking Biology Technology:Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3Neogen CEO adopts 10b5-1 Trading Plan 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3
Cached News: